Formulation and evaluation of polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata

Somnath D. Bhinge; Mangesh A. Bhutkar; Dheeraj Randive; Ganesh H. Wadkar; Sanjeeva Y. Kamble; Pooja D. Kalel; Sneha S. Kadam

Formulation and evaluation of polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata

Abstract

In the Indian system of medicine-Ayurveda, azadirachta indica, adhatoda vasica, piper betle, ocimum tenuiflorum and pongamia pinnata has been mentioned as a remedy for treatment of various infectious diseases and ailments. Based on the folkloric use, the present study was designed to formulate and evaluate polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata. Gel formulations (Formulation A, B and C) were prepared which comprised of the ethanolic extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata in a concentration of 0.1, 0.3 and 0.5 %, respectively in a base. The prepared formulations were evaluated for appearance and homogeneity, pH, viscosity and rheological studies, spreadability, skin irritation test (patch test) and washability. The formulations were also screened for their antimicrobial activity by disc plate method against S. aureus, B. subtilis, A. niger and E. coli. The results of the studies revealed that all formulations under study viz. A, B and C showed better zone of inhibition as compared with the control. However, formulation C exhibited maximum activity against the selected strains which may be attributed to its greater amount of herbal extracts as compared to formulation A and B. The polyherbal gel formulations were observed to possess antimicrobial action. The effective activity may be attributed to the synergistic action of the plants constituents present in the formulation.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy, Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Somnath D. Bhinge ^* This is me
India

Mangesh A. Bhutkar This is me
India

Dheeraj Randive
India

Ganesh H. Wadkar This is me
India

Sanjeeva Y. Kamble This is me
India

Pooja D. Kalel This is me
India

Sneha S. Kadam This is me
India

Publication Date

June 27, 2025

Submission Date

January 31, 2018

Acceptance Date

April 30, 2018

Published in Issue

Year 2019 Volume: 23 Number: 1

IZ

https://izlik.org/JA96WM46TD

Cite

RIS / Bibtex

APA

D. Bhinge, S., A. Bhutkar, M., Randive, D., H. Wadkar, G., Y. Kamble, S., D. Kalel, P., & S. Kadam, S. (2025). Formulation and evaluation of polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata. Journal of Research in Pharmacy, 23(1), 44-54. https://izlik.org/JA96WM46TD

AMA

1.D. Bhinge S, A. Bhutkar M, Randive D, et al. Formulation and evaluation of polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata. J. Res. Pharm. 2025;23(1):44-54. https://izlik.org/JA96WM46TD

Chicago

D. Bhinge, Somnath, Mangesh A. Bhutkar, Dheeraj Randive, et al. 2025. “Formulation and Evaluation of Polyherbal Gel Containing Extracts of Azadirachta Indica, Adhatoda Vasica, Piper Betle, Ocimum Tenuiflorum and Pongamia Pinnata”. Journal of Research in Pharmacy 23 (1): 44-54. https://izlik.org/JA96WM46TD.

EndNote

D. Bhinge S, A. Bhutkar M, Randive D, H. Wadkar G, Y. Kamble S, D. Kalel P, S. Kadam S (June 1, 2025) Formulation and evaluation of polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata. Journal of Research in Pharmacy 23 1 44–54.

IEEE

[1]S. D. Bhinge et al., “Formulation and evaluation of polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata”, J. Res. Pharm., vol. 23, no. 1, pp. 44–54, June 2025, [Online]. Available: https://izlik.org/JA96WM46TD

ISNAD

D. Bhinge, Somnath - A. Bhutkar, Mangesh - Randive, Dheeraj - H. Wadkar, Ganesh - Y. Kamble, Sanjeeva - D. Kalel, Pooja - S. Kadam, Sneha. “Formulation and Evaluation of Polyherbal Gel Containing Extracts of Azadirachta Indica, Adhatoda Vasica, Piper Betle, Ocimum Tenuiflorum and Pongamia Pinnata”. Journal of Research in Pharmacy 23/1 (June 1, 2025): 44-54. https://izlik.org/JA96WM46TD.

JAMA

1.D. Bhinge S, A. Bhutkar M, Randive D, H. Wadkar G, Y. Kamble S, D. Kalel P, S. Kadam S. Formulation and evaluation of polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata. J. Res. Pharm. 2025;23:44–54.

MLA

D. Bhinge, Somnath, et al. “Formulation and Evaluation of Polyherbal Gel Containing Extracts of Azadirachta Indica, Adhatoda Vasica, Piper Betle, Ocimum Tenuiflorum and Pongamia Pinnata”. Journal of Research in Pharmacy, vol. 23, no. 1, June 2025, pp. 44-54, https://izlik.org/JA96WM46TD.

Vancouver

1.Somnath D. Bhinge, Mangesh A. Bhutkar, Dheeraj Randive, Ganesh H. Wadkar, Sanjeeva Y. Kamble, Pooja D. Kalel, Sneha S. Kadam. Formulation and evaluation of polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(1):44-5. Available from: https://izlik.org/JA96WM46TD