Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular modeling studies of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety
Abstract
Herein, we report the in vitro Acetylcholinesterase (AChE) inhibitory activities of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety. The compounds were characterized by diverse spectral methods and reported by our research team previously. As a novelty we conducted in vitro AChE inhibitory activities of the title compounds and performed in silico studies to provide insight related to activity mechanism of the compounds. Compound 4f displayed the best biological activity within our compounds with 69.92% enzyme inhibition value (at a final concentration of 0.08 mg/mL) and 0.0245 mg/mL IC50 value.
Keywords
References
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Details
Primary Language
English
Subjects
Pharmaceutical Chemistry
Journal Section
Research Article
Authors
Publication Date
June 28, 2025
Submission Date
October 19, 2023
Acceptance Date
December 4, 2023
Published in Issue
Year 2024 Volume: 28 Number: 1
APA
Dincel, E. D., Hasbal Çelikok, G., Yılmaz Özden, T., & Ulusoy Güzeldemirci, N. (2025). Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular modeling studies of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety. Journal of Research in Pharmacy, 28(1), 155-163. https://izlik.org/JA95HH93LS
AMA
1.Dincel ED, Hasbal Çelikok G, Yılmaz Özden T, Ulusoy Güzeldemirci N. Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular modeling studies of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety. J. Res. Pharm. 2025;28(1):155-163. https://izlik.org/JA95HH93LS
Chicago
Dincel, Efe Doğukan, Gozde Hasbal Çelikok, Tuğba Yılmaz Özden, and Nuray Ulusoy Güzeldemirci. 2025. “Synthesis, in Vitro Acetylcholinesterase Inhibitory Activity and Molecular Modeling Studies of Imidazo[2,1-B]thiazole Derivatives Bearing Thiosemicarbazide Moiety”. Journal of Research in Pharmacy 28 (1): 155-63. https://izlik.org/JA95HH93LS.
EndNote
Dincel ED, Hasbal Çelikok G, Yılmaz Özden T, Ulusoy Güzeldemirci N (June 1, 2025) Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular modeling studies of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety. Journal of Research in Pharmacy 28 1 155–163.
IEEE
[1]E. D. Dincel, G. Hasbal Çelikok, T. Yılmaz Özden, and N. Ulusoy Güzeldemirci, “Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular modeling studies of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety”, J. Res. Pharm., vol. 28, no. 1, pp. 155–163, June 2025, [Online]. Available: https://izlik.org/JA95HH93LS
ISNAD
Dincel, Efe Doğukan - Hasbal Çelikok, Gozde - Yılmaz Özden, Tuğba - Ulusoy Güzeldemirci, Nuray. “Synthesis, in Vitro Acetylcholinesterase Inhibitory Activity and Molecular Modeling Studies of Imidazo[2,1-B]thiazole Derivatives Bearing Thiosemicarbazide Moiety”. Journal of Research in Pharmacy 28/1 (June 1, 2025): 155-163. https://izlik.org/JA95HH93LS.
JAMA
1.Dincel ED, Hasbal Çelikok G, Yılmaz Özden T, Ulusoy Güzeldemirci N. Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular modeling studies of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety. J. Res. Pharm. 2025;28:155–163.
MLA
Dincel, Efe Doğukan, et al. “Synthesis, in Vitro Acetylcholinesterase Inhibitory Activity and Molecular Modeling Studies of Imidazo[2,1-B]thiazole Derivatives Bearing Thiosemicarbazide Moiety”. Journal of Research in Pharmacy, vol. 28, no. 1, June 2025, pp. 155-63, https://izlik.org/JA95HH93LS.
Vancouver
1.Efe Doğukan Dincel, Gozde Hasbal Çelikok, Tuğba Yılmaz Özden, Nuray Ulusoy Güzeldemirci. Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular modeling studies of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety. J. Res. Pharm. [Internet]. 2025 Jun. 1;28(1):155-63. Available from: https://izlik.org/JA95HH93LS