A new approach to oral dosage forms: carrageenan-based vegan gummies

Hazal Ezgi Gültekin; Miray İlhan; Fırat Nalbantoğlu

A new approach to oral dosage forms: carrageenan-based vegan gummies

Abstract

Although the oral route is a common drug administration route, it still causes some patient compliance problems. Gummies are chewable gels that are commonly manufactured as dietary supplement carriers and their pharmaceutical use is still limited. Dexketoprofen trometamol is an anti-inflammatory and antipyretic drug. In the present study, dexketoprofen containing gummies were manufactured using carrageenan (Gelcarin®GP-379) as the gel-forming polymer. Potassium dihydrogen phosphate (KH2PO4) was used as the gelling agent in the research. The obtained gummies were characterized. For this purpose, gel viscosity measurements, morphological and physical characterizations, thermal analysis, and in vitro drug release studies were carried out. The viscosity of the gel mixtures was measured at 50°C, which was the pouring temperature of the gels into molds. The formulation containing the highest carrageenan and KH2PO4 had the highest viscosity. The physical characterization results showed that the gummy formulations could be prepared in a reproducible manner. The DSC thermograms showed that the melting peak of DXT was not observed in the gummy formulation. The in vitro dissolution test results of the gummies showed that decreasing the carrageenan and KH2PO4 concentration in gummy formulation accelerated the drug release. The obtained gummies exhibited an extended-release of up to 2 hours.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Hazal Ezgi Gültekin ^*
0000-0001-6438-8006
Türkiye

Miray İlhan This is me
0000-0003-1749-5129
Türkiye

Fırat Nalbantoğlu This is me
0009-0008-2207-4242
Türkiye

Publication Date

June 28, 2025

Submission Date

March 15, 2023

Acceptance Date

June 10, 2023

Published in Issue

Year 2024 Volume: 28 Number: 1

IZ

https://izlik.org/JA27DR95JH

Cite

RIS / Bibtex

APA

Gültekin, H. E., İlhan, M., & Nalbantoğlu, F. (2025). A new approach to oral dosage forms: carrageenan-based vegan gummies. Journal of Research in Pharmacy, 28(1), 225-235. https://izlik.org/JA27DR95JH

AMA

1.Gültekin HE, İlhan M, Nalbantoğlu F. A new approach to oral dosage forms: carrageenan-based vegan gummies. J. Res. Pharm. 2025;28(1):225-235. https://izlik.org/JA27DR95JH

Chicago

Gültekin, Hazal Ezgi, Miray İlhan, and Fırat Nalbantoğlu. 2025. “A New Approach to Oral Dosage Forms: Carrageenan-Based Vegan Gummies”. Journal of Research in Pharmacy 28 (1): 225-35. https://izlik.org/JA27DR95JH.

EndNote

Gültekin HE, İlhan M, Nalbantoğlu F (June 1, 2025) A new approach to oral dosage forms: carrageenan-based vegan gummies. Journal of Research in Pharmacy 28 1 225–235.

IEEE

[1]H. E. Gültekin, M. İlhan, and F. Nalbantoğlu, “A new approach to oral dosage forms: carrageenan-based vegan gummies”, J. Res. Pharm., vol. 28, no. 1, pp. 225–235, June 2025, [Online]. Available: https://izlik.org/JA27DR95JH

ISNAD

Gültekin, Hazal Ezgi - İlhan, Miray - Nalbantoğlu, Fırat. “A New Approach to Oral Dosage Forms: Carrageenan-Based Vegan Gummies”. Journal of Research in Pharmacy 28/1 (June 1, 2025): 225-235. https://izlik.org/JA27DR95JH.

JAMA

1.Gültekin HE, İlhan M, Nalbantoğlu F. A new approach to oral dosage forms: carrageenan-based vegan gummies. J. Res. Pharm. 2025;28:225–235.

MLA

Gültekin, Hazal Ezgi, et al. “A New Approach to Oral Dosage Forms: Carrageenan-Based Vegan Gummies”. Journal of Research in Pharmacy, vol. 28, no. 1, June 2025, pp. 225-3, https://izlik.org/JA27DR95JH.

Vancouver

1.Hazal Ezgi Gültekin, Miray İlhan, Fırat Nalbantoğlu. A new approach to oral dosage forms: carrageenan-based vegan gummies. J. Res. Pharm. [Internet]. 2025 Jun. 1;28(1):225-3. Available from: https://izlik.org/JA27DR95JH