Nuclear receptor agonist activity studies on some Plantago species and Scutellaria salviifolia Benth.: A particular focus on liver x receptor alpha and retinoid x receptor alpha connected with the inflammation process

Vahap Murat Kutluay; Yasin Genç; Zeynep Doğan; Makoto Makoto Inoue; İclal Saraçoğlu

Nuclear receptor agonist activity studies on some Plantago species and Scutellaria salviifolia Benth.: A particular focus on liver x receptor alpha and retinoid x receptor alpha connected with the inflammation process

Abstract

Plantago, Scutellaria, liver Nuclear receptors are a superfamily of transcription factors that regulate gene transcription and intracellular function. They have a key role in various biological processes. Liver X receptors (LXR) mainly play role in lipid metabolism, cholesterol synthesis, glucose homeostasis, and inflammation whereas retinoid X receptor alpha (RXRα) plays important role in inflammation and immunity. In this study, Plantago holosteum, P. major subsp. major, P. lagopus, P. scabra, and Scutellaria salviifolia were selected for further investigation due to their anti-inflammatory activities. For this purpose, liver x receptor alpha (LXRα) and retinoid x receptor alpha (RXRα) agonist activity of the extracts was determined through luciferase reporter gene assay on HEK293 cells at a concentration of 100 µg/ml. P. holosteum, P. major subsp. major, P. lagopus, and P. scabra extracts showed weak LXRα agonist activity with the fold values in a range of 0.95-1.39. P. major showed the highest agonist activity among tested Plantago species. For LXRα agonist activity, S. salviifolia extract had a fold value of 2.37 which was comparable to the positive control T09011317 at 10 nM concentration. Results for RXRα agonist activity found to be similar to LXRα for all extracts. S. salviifolia showed the highest RXRα agonist activity with a fold value of 1.62. Results suggested that Scutellaria species, which are used as traditional medicine especially in eastern Asia due to its anti-inflammatory effects, might show this effect due to LXRα activation. x receptor,retinoid x receptor, anti-inflammatory

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

Vahap Murat Kutluay ^*
0000-0003-4135-3497
Türkiye

Yasin Genç
0000-0002-5408-7565
Türkiye

Zeynep Doğan
0000-0002-0108-6040
Türkiye

Makoto Makoto Inoue This is me
0000-0003-0116-320X
Japan

İclal Saraçoğlu
0000-0003-0555-6262
Türkiye

Publication Date

June 28, 2025

Submission Date

January 18, 2021

Acceptance Date

January 17, 2022

Published in Issue

Year 2022 Volume: 26 Number: 2

IZ

https://izlik.org/JA72RB42WU

Cite

RIS / Bibtex

APA

Kutluay, V. M., Genç, Y., Doğan, Z., Makoto Inoue, M., & Saraçoğlu, İ. (2025). Nuclear receptor agonist activity studies on some Plantago species and Scutellaria salviifolia Benth.: A particular focus on liver x receptor alpha and retinoid x receptor alpha connected with the inflammation process. Journal of Research in Pharmacy, 26(2), 272-278. https://izlik.org/JA72RB42WU

AMA

1.Kutluay VM, Genç Y, Doğan Z, Makoto Inoue M, Saraçoğlu İ. Nuclear receptor agonist activity studies on some Plantago species and Scutellaria salviifolia Benth.: A particular focus on liver x receptor alpha and retinoid x receptor alpha connected with the inflammation process. J. Res. Pharm. 2025;26(2):272-278. https://izlik.org/JA72RB42WU

Chicago

Kutluay, Vahap Murat, Yasin Genç, Zeynep Doğan, Makoto Makoto Inoue, and İclal Saraçoğlu. 2025. “Nuclear Receptor Agonist Activity Studies on Some Plantago Species and Scutellaria Salviifolia Benth.: A Particular Focus on Liver X Receptor Alpha and Retinoid X Receptor Alpha Connected With the Inflammation Process”. Journal of Research in Pharmacy 26 (2): 272-78. https://izlik.org/JA72RB42WU.

EndNote

Kutluay VM, Genç Y, Doğan Z, Makoto Inoue M, Saraçoğlu İ (June 1, 2025) Nuclear receptor agonist activity studies on some Plantago species and Scutellaria salviifolia Benth.: A particular focus on liver x receptor alpha and retinoid x receptor alpha connected with the inflammation process. Journal of Research in Pharmacy 26 2 272–278.

IEEE

[1]V. M. Kutluay, Y. Genç, Z. Doğan, M. Makoto Inoue, and İ. Saraçoğlu, “Nuclear receptor agonist activity studies on some Plantago species and Scutellaria salviifolia Benth.: A particular focus on liver x receptor alpha and retinoid x receptor alpha connected with the inflammation process”, J. Res. Pharm., vol. 26, no. 2, pp. 272–278, June 2025, [Online]. Available: https://izlik.org/JA72RB42WU

ISNAD

Kutluay, Vahap Murat - Genç, Yasin - Doğan, Zeynep - Makoto Inoue, Makoto - Saraçoğlu, İclal. “Nuclear Receptor Agonist Activity Studies on Some Plantago Species and Scutellaria Salviifolia Benth.: A Particular Focus on Liver X Receptor Alpha and Retinoid X Receptor Alpha Connected With the Inflammation Process”. Journal of Research in Pharmacy 26/2 (June 1, 2025): 272-278. https://izlik.org/JA72RB42WU.

JAMA

1.Kutluay VM, Genç Y, Doğan Z, Makoto Inoue M, Saraçoğlu İ. Nuclear receptor agonist activity studies on some Plantago species and Scutellaria salviifolia Benth.: A particular focus on liver x receptor alpha and retinoid x receptor alpha connected with the inflammation process. J. Res. Pharm. 2025;26:272–278.

MLA

Kutluay, Vahap Murat, et al. “Nuclear Receptor Agonist Activity Studies on Some Plantago Species and Scutellaria Salviifolia Benth.: A Particular Focus on Liver X Receptor Alpha and Retinoid X Receptor Alpha Connected With the Inflammation Process”. Journal of Research in Pharmacy, vol. 26, no. 2, June 2025, pp. 272-8, https://izlik.org/JA72RB42WU.

Vancouver

1.Vahap Murat Kutluay, Yasin Genç, Zeynep Doğan, Makoto Makoto Inoue, İclal Saraçoğlu. Nuclear receptor agonist activity studies on some Plantago species and Scutellaria salviifolia Benth.: A particular focus on liver x receptor alpha and retinoid x receptor alpha connected with the inflammation process. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(2):272-8. Available from: https://izlik.org/JA72RB42WU