5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents

Year 2020, Volume: 24 Issue: 1, 30 - 37, 27.06.2025

Ahmet Serhat Ekinci Jan Moncol Siva Krishna Vagolu , Sriram Dharmarajan , Keriman Ozadalı Sarı

https://doi.org/10.35333/jrp.2020.110

Cited By: 5

https://izlik.org/JA37AJ25UN

Abstract

This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds (2a and 2c) were determined by the single-crystal Xray diffraction study. Among the target compounds, 2-(4-ethoxyphenyl)-5-methyl-3-(phenylamino)thiazolidin-4-one (2g) was promising with a minimum inhibitory concentration of 12.5 μg/mL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity.

Keywords

Antimycobacterial , tuberculosis , 4-thiazolidinone , single-crystal X-ray diffraction

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