Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films

Muhammet Davut Arpa; Melike Zeynep Ünükür; Ümit Can Erim

Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films

Abstract

Buccal administration of different active ingredients as an alternative to oral or dermal routes has been widely studied. The films are one of the most investigated dosage forms regarding the buccal formulations developed using bioadhesive polymers. Having thin and flexible structures, the films remain in the mouth for their duration of action without causing any discomfort. There are many studies conducted to develop buccal films for local treatment of oral fungal infections. In this research, buccal films were prepared using terbinafine hydrochloride, which is frequently used orally and systemically in the treatment of fungal infections and has low water solubility. The films were prepared by solvent casting method using hydroxypropyl methyl cellulose (HPMC) and polyvinyl pyrrolidone K30 (PVP) as the bioadhesive polymers and glycerin (2-3%) as the plasticizer. Characterization properties including thickness, weight uniformity, flexibility, tensile strength, swelling capacity were examined and the bioadhesive characteristics were determined by Texture Analyzer device using bovine buccal tissue. According to the findings of bioadhesion studies, the highest bioadhesive properties were detected in F1 and F7 formulations, which contained 5% HPMC. In vitro release studies exhibited that F1 and F7 film formulations with 5% HPMC represented slower and more controlled release compared to F2 and F8 film formulations having 4% HPMC + 1% PVP. The results revealed that the developed buccal formulations loaded with terbinafine hydrochloride might be convenient for the local treatment of oral fungal infections.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Muhammet Davut Arpa ^*
Türkiye

Melike Zeynep Ünükür This is me
Türkiye

Ümit Can Erim This is me
Türkiye

Publication Date

June 28, 2025

Submission Date

March 20, 2021

Acceptance Date

July 13, 2021

Published in Issue

Year 2021 Volume: 25 Number: 5

IZ

https://izlik.org/JA74YM96MC

Cite

RIS / Bibtex

APA

Arpa, M. D., Ünükür, M. Z., & Erim, Ü. C. (2025). Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films. Journal of Research in Pharmacy, 25(5), 667-680. https://izlik.org/JA74YM96MC

AMA

1.Arpa MD, Ünükür MZ, Erim ÜC. Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films. J. Res. Pharm. 2025;25(5):667-680. https://izlik.org/JA74YM96MC

Chicago

Arpa, Muhammet Davut, Melike Zeynep Ünükür, and Ümit Can Erim. 2025. “Formulation, Characterization and in Vitro Release Studies of Terbinafine Hydrochloride Loaded Buccal Films”. Journal of Research in Pharmacy 25 (5): 667-80. https://izlik.org/JA74YM96MC.

EndNote

Arpa MD, Ünükür MZ, Erim ÜC (July 1, 2025) Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films. Journal of Research in Pharmacy 25 5 667–680.

IEEE

[1]M. D. Arpa, M. Z. Ünükür, and Ü. C. Erim, “Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films”, J. Res. Pharm., vol. 25, no. 5, pp. 667–680, July 2025, [Online]. Available: https://izlik.org/JA74YM96MC

ISNAD

Arpa, Muhammet Davut - Ünükür, Melike Zeynep - Erim, Ümit Can. “Formulation, Characterization and in Vitro Release Studies of Terbinafine Hydrochloride Loaded Buccal Films”. Journal of Research in Pharmacy 25/5 (July 1, 2025): 667-680. https://izlik.org/JA74YM96MC.

JAMA

1.Arpa MD, Ünükür MZ, Erim ÜC. Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films. J. Res. Pharm. 2025;25:667–680.

MLA

Arpa, Muhammet Davut, et al. “Formulation, Characterization and in Vitro Release Studies of Terbinafine Hydrochloride Loaded Buccal Films”. Journal of Research in Pharmacy, vol. 25, no. 5, July 2025, pp. 667-80, https://izlik.org/JA74YM96MC.

Vancouver

1.Muhammet Davut Arpa, Melike Zeynep Ünükür, Ümit Can Erim. Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films. J. Res. Pharm. [Internet]. 2025 Jul. 1;25(5):667-80. Available from: https://izlik.org/JA74YM96MC