Platanus orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage

Betül Ayaz Adakul; Ali Şen; Tarık Şener; Ömer Erdoğan; Ozge Cevik; Pınar Eker; Şule Çetinel; Furkan Bölükbaşi; İsmail Şenkardeş; Büşra Ertaş; Göksel Şener

Platanus orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage

Abstract

The aim of this study is to determine whether Platanus orientalis (PO) which has anti-inflammatory, antioxidant and diuretic properties and used in the treatment of kidney stones as traditional folk medicine, will reduce or prevent the stone formation in the urinary system. To simulate the urolithiasis model 0.75% ethylene glycol (EG) and 1% ammonium chloride (AC) were applied to Sprague-Dawley rats. The rats were divided into four groups (n=8). The control group was given standard drinking water for 5 weeks. EG group received 0.75% EG in their drinking water containing 0.75% EG and 1% AC. PO extract (100 mg/kg) was given orally for 5 weeks to the preventive group and for last 2 weeks to the therapeutic group, respectively. At the end of experiment, 24-hour urine and kidney samples were obtained. In urine samples, calcium and citrate levels were decreased and oxalate level was increased in the EG group. In kidney samples myeloperoxidase, caspase-3, N-acetyl-β-glycosaminidase (NAG) activities, malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), tumor necrosis factor-α and interleukin-1β levels were increased while superoxide dismutase activity and glutathione levels were decreased in the EG group. These biochemical parameters returned to control levels in both PO treatment groups. Histological findings also correlate with these results. Our findings are suggested that PO treatments is effective in both preventive and therapeutic groups.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Betül Ayaz Adakul This is me
0000-0003-0752-124X
Türkiye

Ali Şen
0000-0002-2144-5741
Türkiye

Tarık Şener
0000-0003-0085-7680
Türkiye

Ömer Erdoğan This is me
Türkiye

Ozge Cevik
Türkiye

Pınar Eker
0000-0001-6514-8047
Türkiye

Şule Çetinel This is me
0000-0003-1912-3679
Türkiye

Furkan Bölükbaşi This is me
0000-0002-9524-4109
Türkiye

İsmail Şenkardeş
0000-0002-2656-0319
Türkiye

Büşra Ertaş
0000-0001-8374-1098
Türkiye

Göksel Şener ^*
0000-0001-7444-6193
Türkiye

Publication Date

June 28, 2025

Submission Date

October 19, 2021

Acceptance Date

December 29, 2021

Published in Issue

Year 2022 Volume: 26 Number: 2

IZ

https://izlik.org/JA22LD39WZ

Cite

RIS / Bibtex

APA

Ayaz Adakul, B., Şen, A., Şener, T., Erdoğan, Ö., Cevik, O., Eker, P., Çetinel, Ş., Bölükbaşi, F., Şenkardeş, İ., Ertaş, B., & Şener, G. (2025). Platanus orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage. Journal of Research in Pharmacy, 26(2), 311-324. https://izlik.org/JA22LD39WZ

AMA

1.Ayaz Adakul B, Şen A, Şener T, et al. Platanus orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage. J. Res. Pharm. 2025;26(2):311-324. https://izlik.org/JA22LD39WZ

Chicago

Ayaz Adakul, Betül, Ali Şen, Tarık Şener, et al. 2025. “Platanus Orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage”. Journal of Research in Pharmacy 26 (2): 311-24. https://izlik.org/JA22LD39WZ.

EndNote

Ayaz Adakul B, Şen A, Şener T, Erdoğan Ö, Cevik O, Eker P, Çetinel Ş, Bölükbaşi F, Şenkardeş İ, Ertaş B, Şener G (June 1, 2025) Platanus orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage. Journal of Research in Pharmacy 26 2 311–324.

IEEE

[1]B. Ayaz Adakul et al., “Platanus orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage”, J. Res. Pharm., vol. 26, no. 2, pp. 311–324, June 2025, [Online]. Available: https://izlik.org/JA22LD39WZ

ISNAD

Ayaz Adakul, Betül - Şen, Ali - Şener, Tarık - Erdoğan, Ömer - Cevik, Ozge - Eker, Pınar - Çetinel, Şule et al. “Platanus Orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage”. Journal of Research in Pharmacy 26/2 (June 1, 2025): 311-324. https://izlik.org/JA22LD39WZ.

JAMA

1.Ayaz Adakul B, Şen A, Şener T, Erdoğan Ö, Cevik O, Eker P, Çetinel Ş, Bölükbaşi F, Şenkardeş İ, Ertaş B, Şener G. Platanus orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage. J. Res. Pharm. 2025;26:311–324.

MLA

Ayaz Adakul, Betül, et al. “Platanus Orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage”. Journal of Research in Pharmacy, vol. 26, no. 2, June 2025, pp. 311-24, https://izlik.org/JA22LD39WZ.

Vancouver

1.Betül Ayaz Adakul, Ali Şen, Tarık Şener, Ömer Erdoğan, Ozge Cevik, Pınar Eker, Şule Çetinel, Furkan Bölükbaşi, İsmail Şenkardeş, Büşra Ertaş, Göksel Şener. Platanus orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(2):311-24. Available from: https://izlik.org/JA22LD39WZ