Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium

Dilara Örgül

Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium

Abstract

The present work focuses on the inclusion complexations (ICs) of rosuvastatin calcium (RSV) with beta () ve gama () derivatives of native cyclodextrins (CDs) and investigate effects on improved solubility and dissolution rate. The phase solubility studies illustrated that RSV solubility increased in the presence of CD with a negative deviation that indicates AN type diagrams, while βCD showed Bs type, upon addition of βCD, an increase in the solubility of the drug was observed up to a particular point. ICs of RSV were prepared with β and CD by at 1:1, 1:2 and 1:4 different molar ratios by freeze drying method. FT-IR and DSC results revealed formation of ICs between RSV and CD. High drug loading efficiency was obtained for all ICs in the range of 99.41–101.84%. Water solubility studies showed that βCD ICs have increased solubility of RSV about 1.3 times regardless of CD ratios(p>0.05). As compared to βCD ICs, RSV solubility was significantly greater in CD ICs and increased up to 1.45, 1.72 and 2.00 fold at 1:1, 1:2 and 1:4 ratio, respectively. Conspicuously, RSV solubility increased with increasing ratio of CD(p<0.05). Compared dissolution profiles with pure RSV, all ICs showed improved dissolution rates and immediate release profiles. However multiple point comparison of dissolution profiles indicated that CD ICs have higher drug release. Particularly CD ICs at 1:4 ratio released the highest RSV with 95.12% at 3 min and 100% completion in 15 min. It is concluded that CD provided a better improvement on RSV solubility and dissolution rate than βCD.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Dilara Örgül ^*
0000-0002-8947-4995
Türkiye

Publication Date

June 28, 2025

Submission Date

August 14, 2023

Acceptance Date

September 21, 2023

Published in Issue

Year 2024 Volume: 28 Number: 3

IZ

https://izlik.org/JA69WX85SH

Cite

RIS / Bibtex

APA

Örgül, D. (2025). Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium. Journal of Research in Pharmacy, 28(3), 797-807. https://izlik.org/JA69WX85SH

AMA

1.Örgül D. Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium. J. Res. Pharm. 2025;28(3):797-807. https://izlik.org/JA69WX85SH

Chicago

Örgül, Dilara. 2025. “Comparison the Solubility and Dissolution Rate Effects of Beta-Cyclodextrin and Gamma-Cyclodextrin Complexations of Rosuvastatin Calcium”. Journal of Research in Pharmacy 28 (3): 797-807. https://izlik.org/JA69WX85SH.

EndNote

Örgül D (June 1, 2025) Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium. Journal of Research in Pharmacy 28 3 797–807.

IEEE

[1]D. Örgül, “Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium”, J. Res. Pharm., vol. 28, no. 3, pp. 797–807, June 2025, [Online]. Available: https://izlik.org/JA69WX85SH

ISNAD

Örgül, Dilara. “Comparison the Solubility and Dissolution Rate Effects of Beta-Cyclodextrin and Gamma-Cyclodextrin Complexations of Rosuvastatin Calcium”. Journal of Research in Pharmacy 28/3 (June 1, 2025): 797-807. https://izlik.org/JA69WX85SH.

JAMA

1.Örgül D. Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium. J. Res. Pharm. 2025;28:797–807.

MLA

Örgül, Dilara. “Comparison the Solubility and Dissolution Rate Effects of Beta-Cyclodextrin and Gamma-Cyclodextrin Complexations of Rosuvastatin Calcium”. Journal of Research in Pharmacy, vol. 28, no. 3, June 2025, pp. 797-0, https://izlik.org/JA69WX85SH.

Vancouver

1.Dilara Örgül. Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium. J. Res. Pharm. [Internet]. 2025 Jun. 1;28(3):797-80. Available from: https://izlik.org/JA69WX85SH