Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and its Major Metabolite S-(-)-Citronellol

Canan Vejselova Sezer; Hüseyin İzgördü; Gökalp İşcan; Arzu İşcan; Hatice Mehtap Kutlu

Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and its Major Metabolite S-(-)-Citronellol

Abstract

Oil Rose (Rosa x damascena Mill.) has a great economic value in food, pharmaceutical and cosmetic industries with its essential oil obtained by hydrodistillation. Essential oils are usually volatile at room temperature and they have strong biological effects. These aromatic natural extracts have been used for centuries for their therapeutic properties. Turkish Rose oil has great economic value for Türkiye and is widely used in current aromatherapy applications with its sedative and relaxing effects, besides its usage in cosmetic and fragrance industries. Furthermore, rose oil is one of the preferred aromatherapy oils for increasing the quality of life of cancer patients during chemotherapy. In this study, the cytotoxic, proapoptotic and antibacterial effects of rose oil and its major component citronellol were studied on A549 human lung cancer cells and Beas-2B healthy human lung epithelial cells. Antibacterial tests were performed with CLSI methods. For cytotoxicity test MTT technique was used. Results showed, cytotoxicity (IC50 value of 16.9 μg/mL), antiproliferative, antibacterial (MIC value of 750 μg/mL) and proapoptotic effects of citronellol. Additionally, morphological and ultrastructural changes indicating apoptosis were detected. Based on the findings, structural alterations in mitochondria and cell membranes, along with chromatin condensation and apoptotic alterations, were observed in A549 cells. Rose oil and citronellol induced apoptosis in both cell lines at different concentrations.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Canan Vejselova Sezer ^*
0000-0002-3792-5993
Türkiye

Hüseyin İzgördü
0000-0002-1377-2988
Türkiye

Gökalp İşcan
0000-0003-1210-0490
Türkiye

Arzu İşcan
0000-0002-0999-7228
Türkiye

Hatice Mehtap Kutlu
0000-0002-8816-1487
Türkiye

Publication Date

June 28, 2025

Submission Date

December 1, 2023

Acceptance Date

February 23, 2024

Published in Issue

Year 2024 Volume: 28 Number: 4

IZ

https://izlik.org/JA48TD77DD

Cite

RIS / Bibtex

APA

Vejselova Sezer, C., İzgördü, H., İşcan, G., İşcan, A., & Kutlu, H. M. (2025). Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and its Major Metabolite S-(-)-Citronellol. Journal of Research in Pharmacy, 28(4), 899-911. https://izlik.org/JA48TD77DD

AMA

1.Vejselova Sezer C, İzgördü H, İşcan G, İşcan A, Kutlu HM. Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and its Major Metabolite S-(-)-Citronellol. J. Res. Pharm. 2025;28(4):899-911. https://izlik.org/JA48TD77DD

Chicago

Vejselova Sezer, Canan, Hüseyin İzgördü, Gökalp İşcan, Arzu İşcan, and Hatice Mehtap Kutlu. 2025. “Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and Its Major Metabolite S-(-)-Citronellol”. Journal of Research in Pharmacy 28 (4): 899-911. https://izlik.org/JA48TD77DD.

EndNote

Vejselova Sezer C, İzgördü H, İşcan G, İşcan A, Kutlu HM (July 1, 2025) Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and its Major Metabolite S-(-)-Citronellol. Journal of Research in Pharmacy 28 4 899–911.

IEEE

[1]C. Vejselova Sezer, H. İzgördü, G. İşcan, A. İşcan, and H. M. Kutlu, “Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and its Major Metabolite S-(-)-Citronellol”, J. Res. Pharm., vol. 28, no. 4, pp. 899–911, July 2025, [Online]. Available: https://izlik.org/JA48TD77DD

ISNAD

Vejselova Sezer, Canan - İzgördü, Hüseyin - İşcan, Gökalp - İşcan, Arzu - Kutlu, Hatice Mehtap. “Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and Its Major Metabolite S-(-)-Citronellol”. Journal of Research in Pharmacy 28/4 (July 1, 2025): 899-911. https://izlik.org/JA48TD77DD.

JAMA

1.Vejselova Sezer C, İzgördü H, İşcan G, İşcan A, Kutlu HM. Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and its Major Metabolite S-(-)-Citronellol. J. Res. Pharm. 2025;28:899–911.

MLA

Vejselova Sezer, Canan, et al. “Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and Its Major Metabolite S-(-)-Citronellol”. Journal of Research in Pharmacy, vol. 28, no. 4, July 2025, pp. 899-11, https://izlik.org/JA48TD77DD.

Vancouver

1.Canan Vejselova Sezer, Hüseyin İzgördü, Gökalp İşcan, Arzu İşcan, Hatice Mehtap Kutlu. Cytotoxic and Antimicrobial Activities of Turkish Rose Oil and its Major Metabolite S-(-)-Citronellol. J. Res. Pharm. [Internet]. 2025 Jul. 1;28(4):899-911. Available from: https://izlik.org/JA48TD77DD