A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use

Eda Aydin Guldur; Erdem Karabulut; Gülbin Özçelikay

A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use

Abstract

Irrational use of antibiotics and antibiotic resistance are one of the major problems encountered in healthcare services. Antibiotic stewardship programs (ASPs) have been one of the most successful attempts in hospitals to control antibiotic resistance. Pharmacists are the core health professionals in ASPs. This study aimed to examine the effect of clinical pharmacist-led ASPs on antibiotic consumption with meta-analysis. ScienceDirect, PubMed, MEDLINE and Cochrane databases were searched for relevant studies. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline was used to identify studies for the review. Methodological quality was assessed using Newcastle-Ottawa scale (NOS) and National Heart, Lung and Blood Institute (NHLBI) pre-post comparison studies quality tool. The R (version 4.0.3.) and metafor packages (version 2.1-0) were used for a random-effects meta- analysis. After pharmacist intervention, the pooled rational use of antibiotics was determined as 0.28 (28% improvement, I2=98.26; 95% CI 0.15-0.41). The pooled duration of therapy data was determined as 0.41 (41% reduction, I2=96.30%; 95% CI 0.54-0.29) in favor of the group with the pharmacist’s intervention. As a result of this study, it was determined that clinical pharmacists took part in the evaluation of the patient, regulation of the treatment, follow-up of the patient after treatment, and education in ASPs. These findings can contribute to improving the role of the pharmacist in ASPs and rational antibiotic use, thereby controlling antibiotic resistance.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Review

Authors

Eda Aydin Guldur This is me
0000-0001-8263-1583
Türkiye

Erdem Karabulut
Türkiye

Gülbin Özçelikay
0000-0002-1580-5050
Türkiye

Publication Date

June 28, 2025

Submission Date

March 23, 2023

Acceptance Date

August 7, 2023

Published in Issue

Year 2024 Volume: 28 Number: 4

IZ

https://izlik.org/JA54YG38RC

Cite

RIS / Bibtex

APA

Aydin Guldur, E., Karabulut, E., & Özçelikay, G. (2025). A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. Journal of Research in Pharmacy, 28(4), 912-922. https://izlik.org/JA54YG38RC

AMA

1.Aydin Guldur E, Karabulut E, Özçelikay G. A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. J. Res. Pharm. 2025;28(4):912-922. https://izlik.org/JA54YG38RC

Chicago

Aydin Guldur, Eda, Erdem Karabulut, and Gülbin Özçelikay. 2025. “A Systematic Review and Meta-Analysis: The Effect of Pharmacist-Led Antibiotic Stewardship Programs on Antibiotic Consumption and Rational Use”. Journal of Research in Pharmacy 28 (4): 912-22. https://izlik.org/JA54YG38RC.

EndNote

Aydin Guldur E, Karabulut E, Özçelikay G (July 1, 2025) A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. Journal of Research in Pharmacy 28 4 912–922.

IEEE

[1]E. Aydin Guldur, E. Karabulut, and G. Özçelikay, “A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use”, J. Res. Pharm., vol. 28, no. 4, pp. 912–922, July 2025, [Online]. Available: https://izlik.org/JA54YG38RC

ISNAD

Aydin Guldur, Eda - Karabulut, Erdem - Özçelikay, Gülbin. “A Systematic Review and Meta-Analysis: The Effect of Pharmacist-Led Antibiotic Stewardship Programs on Antibiotic Consumption and Rational Use”. Journal of Research in Pharmacy 28/4 (July 1, 2025): 912-922. https://izlik.org/JA54YG38RC.

JAMA

1.Aydin Guldur E, Karabulut E, Özçelikay G. A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. J. Res. Pharm. 2025;28:912–922.

MLA

Aydin Guldur, Eda, et al. “A Systematic Review and Meta-Analysis: The Effect of Pharmacist-Led Antibiotic Stewardship Programs on Antibiotic Consumption and Rational Use”. Journal of Research in Pharmacy, vol. 28, no. 4, July 2025, pp. 912-2, https://izlik.org/JA54YG38RC.

Vancouver

1.Eda Aydin Guldur, Erdem Karabulut, Gülbin Özçelikay. A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. J. Res. Pharm. [Internet]. 2025 Jul. 1;28(4):912-2. Available from: https://izlik.org/JA54YG38RC