Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Shieh Ting Kan; Mohamad Syahrizal Ahmad; Saripah Salbiah Syed Abdul Azziz; Khalijah Awang; Yuhanis Mhd Bakri; Mohd Azlan Nafiah; Phirdaous Abbas; Yumi Zuhanis Has-yun Hashim

Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Abstract

Study on the chemical constituents of the dichloromethane (DCM) crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine (1), Omethylmoschatoline (2), lysicamine (3) and cepharadione-A (4) which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data (1H, 13C and LCMS) and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biochemistry, Pharmaceutical Biotechnology

Journal Section

Research Article

Authors

Shieh Ting Kan This is me
Malaysia

Mohamad Syahrizal Ahmad ^* This is me
0000-0002-9278-6332
Malaysia

Saripah Salbiah Syed Abdul Azziz This is me
Malaysia

Khalijah Awang This is me
Malaysia

Yuhanis Mhd Bakri This is me
Malaysia

Mohd Azlan Nafiah
Malaysia

Phirdaous Abbas This is me
Malaysia

Yumi Zuhanis Has-yun Hashim This is me
Malaysia

Publication Date

June 27, 2025

Submission Date

January 5, 2018

Acceptance Date

June 29, 2018

Published in Issue

Year 2019 Volume: 23 Number: 2

IZ

https://izlik.org/JA26EN39YR

Cite

RIS / Bibtex

APA

Kan, S. T., Ahmad, M. S., Syed Abdul Azziz, S. S., Awang, K., Mhd Bakri, Y., Nafiah, M. A., Abbas, P., & Hashim, Y. Z. H.- yun. (2025). Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line. Journal of Research in Pharmacy, 23(2), 217-223. https://izlik.org/JA26EN39YR

AMA

1.Kan ST, Ahmad MS, Syed Abdul Azziz SS, et al. Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line. J. Res. Pharm. 2025;23(2):217-223. https://izlik.org/JA26EN39YR

Chicago

Kan, Shieh Ting, Mohamad Syahrizal Ahmad, Saripah Salbiah Syed Abdul Azziz, et al. 2025. “Oxoaporphine Alkaloids from the Barks of Platymitra Siamensis Craib (Annonaceae) and Their Cytotoxicity Against MCF-7 Cancer Cell Line”. Journal of Research in Pharmacy 23 (2): 217-23. https://izlik.org/JA26EN39YR.

EndNote

Kan ST, Ahmad MS, Syed Abdul Azziz SS, Awang K, Mhd Bakri Y, Nafiah MA, Abbas P, Hashim YZH- yun (June 1, 2025) Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line. Journal of Research in Pharmacy 23 2 217–223.

IEEE

[1]S. T. Kan et al., “Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line”, J. Res. Pharm., vol. 23, no. 2, pp. 217–223, June 2025, [Online]. Available: https://izlik.org/JA26EN39YR

ISNAD

Kan, Shieh Ting - Ahmad, Mohamad Syahrizal - Syed Abdul Azziz, Saripah Salbiah - Awang, Khalijah - Mhd Bakri, Yuhanis - Nafiah, Mohd Azlan - Abbas, Phirdaous - Hashim, Yumi Zuhanis Has-yun. “Oxoaporphine Alkaloids from the Barks of Platymitra Siamensis Craib (Annonaceae) and Their Cytotoxicity Against MCF-7 Cancer Cell Line”. Journal of Research in Pharmacy 23/2 (June 1, 2025): 217-223. https://izlik.org/JA26EN39YR.

JAMA

1.Kan ST, Ahmad MS, Syed Abdul Azziz SS, Awang K, Mhd Bakri Y, Nafiah MA, Abbas P, Hashim YZH- yun. Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line. J. Res. Pharm. 2025;23:217–223.

MLA

Kan, Shieh Ting, et al. “Oxoaporphine Alkaloids from the Barks of Platymitra Siamensis Craib (Annonaceae) and Their Cytotoxicity Against MCF-7 Cancer Cell Line”. Journal of Research in Pharmacy, vol. 23, no. 2, June 2025, pp. 217-23, https://izlik.org/JA26EN39YR.

Vancouver

1.Shieh Ting Kan, Mohamad Syahrizal Ahmad, Saripah Salbiah Syed Abdul Azziz, Khalijah Awang, Yuhanis Mhd Bakri, Mohd Azlan Nafiah, Phirdaous Abbas, Yumi Zuhanis Has-yun Hashim. Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(2):217-23. Available from: https://izlik.org/JA26EN39YR