Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Year 2019, Volume: 23 Issue: 2 , 217 - 223 , 27.06.2025

Shieh Ting Kan Mohamad Syahrizal Ahmad Saripah Salbiah Syed Abdul Azziz Khalijah Awang Yuhanis Mhd Bakri Mohd Azlan Nafiah , Phirdaous Abbas Yumi Zuhanis Has-yun Hashim

https://izlik.org/JA26EN39YR

Abstract

Study on the chemical constituents of the dichloromethane (DCM) crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine (1), Omethylmoschatoline (2), lysicamine (3) and cepharadione-A (4) which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data (1H, 13C and LCMS) and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra.

Keywords

Platymitra siamensis , Annonaceae , oxoaporphine alkaloids , MCF-7 , cytotoxic activity

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