The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice

Gokcen Tellı; Orçin Telli Atalay

The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice

Abstract

Due to prolonged hyperglycemia many of the diabetic patients suffer from complications such as liver damage. Diabetic patients are known to have the need for liver surgeries more than non-diabetic do. The ischemia reperfusion injuries (IRI) are one of the main complications of these surgeries and the IRI-related increase in oxidative stress has been known to be higher in diabetic patients. Metformin and aerobic exercise are important tools being used especially in type-2 diabetes. However, their effects and roles in liver IRI in type-1 diabetic patients are not known. This study aimed to investigate the effects of metformin and exercise on hepatic IRI in diabetes in streptozotocin induced type-1 diabetic mice. Diabetes was induced by streptozotocin and two weeks after the disease developed, mice were started to treat with metformin and/or aerobic exercise during four-weeks. Blood glucose levels of the mice were measured again and the glucose tolerance test (OGTT) was performed for each mouse. The day after OGTT, ischemia was performed for 45 minutes in the liver and then reperfusion was provided for 5 hours. The liver of the mice was isolated at the end of the experiments. The malondialdehyde, superoxide dismutase and nitrite levels were measured with colorimetric analysis. Metformin reduced the insulin resistance alone and together with aerobic exercise. Oxidative stress in the liver after IRI was diminished both with metformin and/or aerobic exercise in diabetic mice. Our study indicated that metformin accompanied with aerobic exercise might be an important treatment strategy for preventing the IRI in the liver of type-1 diabetic patients.

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Research Article

Authors

Gokcen Tellı
0000-0003-0028-6769
Türkiye

Orçin Telli Atalay
0000-0002-1613-9192
Türkiye

Publication Date

June 28, 2025

Submission Date

October 10, 2021

Acceptance Date

February 23, 2022

Published in Issue

Year 2022 Volume: 26 Number: 3

IZ

https://izlik.org/JA79HB89PS

Cite

RIS / Bibtex

APA

Tellı, G., & Telli Atalay, O. (2025). The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice. Journal of Research in Pharmacy, 26(3), 543-553. https://izlik.org/JA79HB89PS

AMA

1.Tellı G, Telli Atalay O. The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice. J. Res. Pharm. 2025;26(3):543-553. https://izlik.org/JA79HB89PS

Chicago

Tellı, Gokcen, and Orçin Telli Atalay. 2025. “The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice”. Journal of Research in Pharmacy 26 (3): 543-53. https://izlik.org/JA79HB89PS.

EndNote

Tellı G, Telli Atalay O (June 1, 2025) The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice. Journal of Research in Pharmacy 26 3 543–553.

IEEE

[1]G. Tellı and O. Telli Atalay, “The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice”, J. Res. Pharm., vol. 26, no. 3, pp. 543–553, June 2025, [Online]. Available: https://izlik.org/JA79HB89PS

ISNAD

Tellı, Gokcen - Telli Atalay, Orçin. “The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice”. Journal of Research in Pharmacy 26/3 (June 1, 2025): 543-553. https://izlik.org/JA79HB89PS.

JAMA

1.Tellı G, Telli Atalay O. The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice. J. Res. Pharm. 2025;26:543–553.

MLA

Tellı, Gokcen, and Orçin Telli Atalay. “The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice”. Journal of Research in Pharmacy, vol. 26, no. 3, June 2025, pp. 543-5, https://izlik.org/JA79HB89PS.

Vancouver

1.Gokcen Tellı, Orçin Telli Atalay. The Role of Metformin and Aerobic Exercise on The Hepatic Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Mice. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(3):543-5. Available from: https://izlik.org/JA79HB89PS