The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds

Büşra Ertaş; Betul Okuyan; Ali Şen; Feriha Ercan; Hüseyin Önel; Fatih Göger; Göksel Şener

The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds

Abstract

The overall aim of the present research is to evaluate for the first time the curative effect of Cotinus coggygria leaves on burn injury in an experimental burn model along with its anti-inflammatory and antioxidant activity potential. Also, phenolic compounds of C. coggygria were characterised by LC-MS/MS. Wistar albino rats weighing 200-250 g were exposed to 90°C bath for 10 s to induce burn injury, involving 30% of the total body surface area. In the treatment groups, 5% C. coggygria ethanol extract was applied topically as a cream immediately after the burn. Blood and skin tissue samples were taken after decapitation at the 4th and 48th hours following the burn procedure. Interleukin 1-β (IL-1β) and tumour necrosis factor (TNF-α) were determined in serum samples, and hydroxyproline, prostoglandin E2 (PGE2), and myeloperoxidase (MPO) activity and 8-hydroxy-2′-deoxy-guanosine (8-OHdG) levels were determined in skin tissue samples. Increased levels of serum cytokines were decreased with C. coggygria treatment in both periods. MPO activity, prostaglandine (PGE2), and 8-OhdG levels increased, while hydroxyproline levels decreased due to burn damage. On the other hand, these parameters were returned to its normal levels with C. coggygria treatment. In addition, the tissue histology of animals treated with C. coggygria showed a complete epithelialization with increased collagenation. As a result, C. coggygria may be an alternative treatment approach for burns-induced skin damage and wounds.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Büşra Ertaş
0000-0001-8374-1098
Türkiye

Betul Okuyan
0000-0002-4023-2565
Türkiye

Ali Şen
0000-0002-2144-5741
Türkiye

Feriha Ercan
0000-0003-2339-5669
Türkiye

Hüseyin Önel This is me
0000-0003-0992-1677
Türkiye

Fatih Göger
0000-0002-9665-0256
Türkiye

Göksel Şener ^*
0000-0001-7444-6193
Türkiye

Publication Date

June 28, 2025

Submission Date

December 31, 2021

Acceptance Date

February 14, 2022

Published in Issue

Year 2022 Volume: 26 Number: 3

IZ

https://izlik.org/JA62SY28XA

Cite

RIS / Bibtex

APA

Ertaş, B., Okuyan, B., Şen, A., Ercan, F., Önel, H., Göger, F., & Şener, G. (2025). The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. Journal of Research in Pharmacy, 26(3), 554-564. https://izlik.org/JA62SY28XA

AMA

1.Ertaş B, Okuyan B, Şen A, et al. The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. J. Res. Pharm. 2025;26(3):554-564. https://izlik.org/JA62SY28XA

Chicago

Ertaş, Büşra, Betul Okuyan, Ali Şen, et al. 2025. “The Effect of Cotinus Coggygria L. Ethanol Extract in the Treatment of Burn Wounds”. Journal of Research in Pharmacy 26 (3): 554-64. https://izlik.org/JA62SY28XA.

EndNote

Ertaş B, Okuyan B, Şen A, Ercan F, Önel H, Göger F, Şener G (June 1, 2025) The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. Journal of Research in Pharmacy 26 3 554–564.

IEEE

[1]B. Ertaş et al., “The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds”, J. Res. Pharm., vol. 26, no. 3, pp. 554–564, June 2025, [Online]. Available: https://izlik.org/JA62SY28XA

ISNAD

Ertaş, Büşra - Okuyan, Betul - Şen, Ali - Ercan, Feriha - Önel, Hüseyin - Göger, Fatih - Şener, Göksel. “The Effect of Cotinus Coggygria L. Ethanol Extract in the Treatment of Burn Wounds”. Journal of Research in Pharmacy 26/3 (June 1, 2025): 554-564. https://izlik.org/JA62SY28XA.

JAMA

1.Ertaş B, Okuyan B, Şen A, Ercan F, Önel H, Göger F, Şener G. The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. J. Res. Pharm. 2025;26:554–564.

MLA

Ertaş, Büşra, et al. “The Effect of Cotinus Coggygria L. Ethanol Extract in the Treatment of Burn Wounds”. Journal of Research in Pharmacy, vol. 26, no. 3, June 2025, pp. 554-6, https://izlik.org/JA62SY28XA.

Vancouver

1.Büşra Ertaş, Betul Okuyan, Ali Şen, Feriha Ercan, Hüseyin Önel, Fatih Göger, Göksel Şener. The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(3):554-6. Available from: https://izlik.org/JA62SY28XA