Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration

Suresh Velayutham; Manimegalai Arjunan; Thamotharan Govindhaswamy; Muthukumaran Gurupackiyam; Deepan Natarajan; Vivek Srinivasan; Chetan Ashok; J Srikanth

Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration

Abstract

This study was designed to investigate the effect of ethanolic extract of Barleria prionitis leaf in Lipopolysaccharide induced neurodegeneration. Neurodenegeration was induced by administering Lipopolysaccharide (LPS) (1 mg/kg/i.p.) in a Sprague Dawley rat model. Ethanolic extract of Barleria prionitis leaf (EEBPL) at a dose of 200 and 400 mg/kg was given orally to desired group of animals for a period of 14 days. After 14 days of drug treatment, parameters such as in vitro anticholinesterase activity, DPPH Radical Scavenging activity, behavioural test for memory and learning (Elevated plus maze test, Open field test), Acetylcholine (ACh) content, Acetylcholinesterase (AChE) activity, Superoxide dismutase (SOD) activity in brain homogenate were analysed. EEBPL at both doses, i.e., 200 and 400mg/kg, decreased the Acetylcholinesterase level in neurodegenerated rats. The EEBPL (400 mg/kg/p.o) had more pronounced effect on memory and learning which is supported by the results of improvement in the body weight and decreased transfer latency time of neurodegenerated animals in elevated plus maze test. Acetylcholine was found to be decreased in untreated neurodegenerated rats due to neuronal inflammation. The EEBPL (400 mg/kg) doses significantly (P<0.001) increased the SOD activity in neurodegenerated rats. Modulation of acetylcholine level by the EEBPL is related with its potential anti-oxidant and cholinesterase inhibitory activity. Further studies are needed to carry out the isolation of active constituents responsible for the activity.

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Research Article

Authors

Suresh Velayutham This is me
0000-0003-4995-8271
India

Manimegalai Arjunan This is me
0000-0002-1206-6045
India

Thamotharan Govindhaswamy This is me
0000-0002-4244-6399
India

Muthukumaran Gurupackiyam This is me
0000-0001-7286-0286
India

Deepan Natarajan This is me
0000-0001-7286-3479
India

Vivek Srinivasan This is me
0000-0002-2627-3627
India

Chetan Ashok This is me
0000-0002-5345-3658
India

J Srikanth ^*
0000-0003-3514-7654
India

Publication Date

June 28, 2025

Submission Date

November 17, 2022

Acceptance Date

January 16, 2023

Published in Issue

Year 2024 Volume: 28 Number: 3

IZ

https://izlik.org/JA44RT87WK

Cite

RIS / Bibtex

APA

Velayutham, S., Arjunan, M., Govindhaswamy, T., Gurupackiyam, M., Natarajan, D., Srinivasan, V., Ashok, C., & Srikanth, J. (2025). Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration. Journal of Research in Pharmacy, 28(3), 880-890. https://izlik.org/JA44RT87WK

AMA

1.Velayutham S, Arjunan M, Govindhaswamy T, et al. Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration. J. Res. Pharm. 2025;28(3):880-890. https://izlik.org/JA44RT87WK

Chicago

Velayutham, Suresh, Manimegalai Arjunan, Thamotharan Govindhaswamy, et al. 2025. “Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration”. Journal of Research in Pharmacy 28 (3): 880-90. https://izlik.org/JA44RT87WK.

EndNote

Velayutham S, Arjunan M, Govindhaswamy T, Gurupackiyam M, Natarajan D, Srinivasan V, Ashok C, Srikanth J (June 1, 2025) Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration. Journal of Research in Pharmacy 28 3 880–890.

IEEE

[1]S. Velayutham et al., “Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration”, J. Res. Pharm., vol. 28, no. 3, pp. 880–890, June 2025, [Online]. Available: https://izlik.org/JA44RT87WK

ISNAD

Velayutham, Suresh - Arjunan, Manimegalai - Govindhaswamy, Thamotharan - Gurupackiyam, Muthukumaran - Natarajan, Deepan - Srinivasan, Vivek - Ashok, Chetan - Srikanth, J. “Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration”. Journal of Research in Pharmacy 28/3 (June 1, 2025): 880-890. https://izlik.org/JA44RT87WK.

JAMA

1.Velayutham S, Arjunan M, Govindhaswamy T, Gurupackiyam M, Natarajan D, Srinivasan V, Ashok C, Srikanth J. Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration. J. Res. Pharm. 2025;28:880–890.

MLA

Velayutham, Suresh, et al. “Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration”. Journal of Research in Pharmacy, vol. 28, no. 3, June 2025, pp. 880-9, https://izlik.org/JA44RT87WK.

Vancouver

1.Suresh Velayutham, Manimegalai Arjunan, Thamotharan Govindhaswamy, Muthukumaran Gurupackiyam, Deepan Natarajan, Vivek Srinivasan, Chetan Ashok, J Srikanth. Anti-Alzheimer Effect of Ethanolic Extract of Barleria Prionitis Leaf in Lipopolysaccharide Induced Neurodegeneration. J. Res. Pharm. [Internet]. 2025 Jun. 1;28(3):880-9. Available from: https://izlik.org/JA44RT87WK