Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery

Ali Asram Sağıroğlu; Beyza Sümeyye Aydın

Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery

Abstract

Retinyl palmitate (RP), also known as vitamin A palmitate, is a well-known anti-aging ingredient that promotes collagen production, enhances skin flexibility, and decreases the view of fine lines and wrinkles. Squalene, a natural lipid found in the skin, is also known to have anti-aging properties, including moisturizing and protecting the skin from environmental stressors. In this study, we demonstrate the encapsulation of RP and squalene within niosomes, and evaluate the in-vitro release and skin permeation of these active ingredients. The niosomes were prepared using a thin-film hydration method and characterized for their particle size, polydispersity index, zeta potential, and encapsulation efficiency. The encapsulation efficiencies of optimized niosome formulation for RP and Squalene were determined to be 83.5%±2.55% and 91.2%±5.12%, respectively. Narrow size distribution was accomplished with a particle size of 168.4 ± 8.2 nm. Cumulative release of 82.67%±5.23% for RP and 87.12%±5.65% for Squalene was acquired after 24 hours of in-vitro release study in sink conditions. Ex-vivo permeation studies indicated that niosomes had a much higher retention rate for RP and Squalene in both the Stratum Corneum (SC) and viable epidermis/dermis layers when compared to the commercial product. Stability studies showed that the optimized niosomes were convenient for keeping at 4°C for at least 90 days. The outcomes show that niosomes are effective in delivering RP and squalene to the skin and can provide a promising alternative to traditional anti-aging formulations.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Ali Asram Sağıroğlu ^*
0000-0002-6960-6364
Türkiye

Beyza Sümeyye Aydın
0000-0003-4066-1105
Türkiye

Publication Date

June 28, 2025

Submission Date

February 6, 2022

Acceptance Date

June 5, 2023

Published in Issue

Year 2023 Volume: 27 Number: 5

IZ

https://izlik.org/JA73GN85NM

Cite

RIS / Bibtex

APA

Sağıroğlu, A. A., & Aydın, B. S. (2025). Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery. Journal of Research in Pharmacy, 27(5), 1821-1830. https://izlik.org/JA73GN85NM

AMA

1.Sağıroğlu AA, Aydın BS. Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery. J. Res. Pharm. 2025;27(5):1821-1830. https://izlik.org/JA73GN85NM

Chicago

Sağıroğlu, Ali Asram, and Beyza Sümeyye Aydın. 2025. “Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery”. Journal of Research in Pharmacy 27 (5): 1821-30. https://izlik.org/JA73GN85NM.

EndNote

Sağıroğlu AA, Aydın BS (July 1, 2025) Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery. Journal of Research in Pharmacy 27 5 1821–1830.

IEEE

[1]A. A. Sağıroğlu and B. S. Aydın, “Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery”, J. Res. Pharm., vol. 27, no. 5, pp. 1821–1830, July 2025, [Online]. Available: https://izlik.org/JA73GN85NM

ISNAD

Sağıroğlu, Ali Asram - Aydın, Beyza Sümeyye. “Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery”. Journal of Research in Pharmacy 27/5 (July 1, 2025): 1821-1830. https://izlik.org/JA73GN85NM.

JAMA

1.Sağıroğlu AA, Aydın BS. Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery. J. Res. Pharm. 2025;27:1821–1830.

MLA

Sağıroğlu, Ali Asram, and Beyza Sümeyye Aydın. “Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery”. Journal of Research in Pharmacy, vol. 27, no. 5, July 2025, pp. 1821-30, https://izlik.org/JA73GN85NM.

Vancouver

1.Ali Asram Sağıroğlu, Beyza Sümeyye Aydın. Preparation and Characterization of Topical Niosomal Formulation Containing Retinyl Palmitate and Squalane for Enhanced Skin Delivery. J. Res. Pharm. [Internet]. 2025 Jul. 1;27(5):1821-30. Available from: https://izlik.org/JA73GN85NM