The influence of melatonin supplementation against aluminum-induced toxicity in brains of male rats

Omur Karabulut-bulan; Bertan Boran Bayrak; Güner Sarikaya-ünal; Refiye Yanardağ

The influence of melatonin supplementation against aluminum-induced toxicity in brains of male rats

Abstract

Aluminum (Al), an ubiquitous element in nature, enters the body primarily through gastrointestinal tract, respiratory system and skin. Being a powerful neurotoxin for human brain, Al was reported to be involved in the etiology of Alzheimer's disease due to its easy access and accumulation in the central nervous system. Melatonin (Mel) is a tryptophan-derived neurohormone in animals and plants, and produced in the pineal gland of all mammalian species. The present study examines the effects of Mel on Al-induced oxidative stress, inflammation, tissue factor production and brain damage in rat brain. Wistar albino rats were divided into four groups. Group I: control animals; Group II: rats injected with 10 mg/kg Mel; Group III: rats injected with 5 mg/kg Al2(SO4)3; and Group IV: rats injected combination of Al and Mel (5 mg/kg Al2(SO4)3 and 10 mg/kg Mel). Animals were injected three times a week for one month. At the end of the month, rats were sacrificed, their brains were removed. It was found that lipid peroxidation, protein carbonyl, advanced oxidation protein products, hydroxyproline levels, tissue factor, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, myeloperoxidase, acetylcholine esterase, alkaline phosphatase, acid phosphatase and glucose-6-phosphate dehydrogenase activities were increased, while paraoxonase, arylesterase, sodium potassium ATPase activities and glutathione levels were decreased in the Al-treated group. Mel treatment reversed these changes by demonstrating significant antioxidant effects. Results indicated that Mel has potential therapeutic value against Al-induced oxidative stress in the rat brain tissue and these effects may be related to its antioxidant activities.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biochemistry, Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Omur Karabulut-bulan
Türkiye

Bertan Boran Bayrak ^* This is me
Türkiye

Güner Sarikaya-ünal
Türkiye

Refiye Yanardağ
Türkiye

Publication Date

June 27, 2025

Submission Date

September 20, 2018

Acceptance Date

November 3, 2018

Published in Issue

Year 2019 Volume: 23 Number: 2

IZ

https://izlik.org/JA78LA75RZ

Cite

RIS / Bibtex

APA

Karabulut-bulan, O., Bayrak, B. B., Sarikaya-ünal, G., & Yanardağ, R. (2025). The influence of melatonin supplementation against aluminum-induced toxicity in brains of male rats. Journal of Research in Pharmacy, 23(2), 275-283. https://izlik.org/JA78LA75RZ

AMA

1.Karabulut-bulan O, Bayrak BB, Sarikaya-ünal G, Yanardağ R. The influence of melatonin supplementation against aluminum-induced toxicity in brains of male rats. J. Res. Pharm. 2025;23(2):275-283. https://izlik.org/JA78LA75RZ

Chicago

Karabulut-bulan, Omur, Bertan Boran Bayrak, Güner Sarikaya-ünal, and Refiye Yanardağ. 2025. “The Influence of Melatonin Supplementation Against Aluminum-Induced Toxicity in Brains of Male Rats”. Journal of Research in Pharmacy 23 (2): 275-83. https://izlik.org/JA78LA75RZ.

EndNote

Karabulut-bulan O, Bayrak BB, Sarikaya-ünal G, Yanardağ R (June 1, 2025) The influence of melatonin supplementation against aluminum-induced toxicity in brains of male rats. Journal of Research in Pharmacy 23 2 275–283.

IEEE

[1]O. Karabulut-bulan, B. B. Bayrak, G. Sarikaya-ünal, and R. Yanardağ, “The influence of melatonin supplementation against aluminum-induced toxicity in brains of male rats”, J. Res. Pharm., vol. 23, no. 2, pp. 275–283, June 2025, [Online]. Available: https://izlik.org/JA78LA75RZ

ISNAD

Karabulut-bulan, Omur - Bayrak, Bertan Boran - Sarikaya-ünal, Güner - Yanardağ, Refiye. “The Influence of Melatonin Supplementation Against Aluminum-Induced Toxicity in Brains of Male Rats”. Journal of Research in Pharmacy 23/2 (June 1, 2025): 275-283. https://izlik.org/JA78LA75RZ.

JAMA

1.Karabulut-bulan O, Bayrak BB, Sarikaya-ünal G, Yanardağ R. The influence of melatonin supplementation against aluminum-induced toxicity in brains of male rats. J. Res. Pharm. 2025;23:275–283.

MLA

Karabulut-bulan, Omur, et al. “The Influence of Melatonin Supplementation Against Aluminum-Induced Toxicity in Brains of Male Rats”. Journal of Research in Pharmacy, vol. 23, no. 2, June 2025, pp. 275-83, https://izlik.org/JA78LA75RZ.

Vancouver

1.Omur Karabulut-bulan, Bertan Boran Bayrak, Güner Sarikaya-ünal, Refiye Yanardağ. The influence of melatonin supplementation against aluminum-induced toxicity in brains of male rats. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(2):275-83. Available from: https://izlik.org/JA78LA75RZ