Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs)

Çağla Kazaz; Burcu Mesut; Yıldız Özsoy; Emine Meltem Ocak

Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs)

Abstract

Atomoxetine hydrochloride is a selective norepinephrine reuptake inhibitor used for the treatment of attention deficit/hyperactivity disorder. Atomoxetine hydrochloride is available in the form of capsules and oral solutions, yet it has no orally disintegrating form due to its bitter taste. ODTs are formulated to disintegrate rapidly upon contact with saliva and enable oral administration without water or chewing and offer improved patient compliance and ease of administration. Appropriate taste masking has great importance for ODTs. In this study, developing a taste-masked ODT formulation containing atomoxetine hydrochloride produced using the wet granulation method was aimed. Formulations were designed by changing the granulation agent (Hydroxypropylmethylcellulose (HPMC), Gellan gum, Veegum, Polyethylene glycol (PEG) 20000P) and active substance to granulation agent ratio (1:2, 1:3, 1:4). Each formulation was tested physically and chemically. According to the results, it was concluded that Gellan gum is more appropriate for use in ODTs for taste masking.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Çağla Kazaz ^* This is me
Türkiye

Burcu Mesut
Türkiye

Yıldız Özsoy
Türkiye

Emine Meltem Ocak
Türkiye

Publication Date

June 28, 2025

Submission Date

July 20, 2020

Acceptance Date

August 4, 2021

Published in Issue

Year 2021 Volume: 25 Number: 5

IZ

https://izlik.org/JA66RB85TF

Cite

RIS / Bibtex

APA

Kazaz, Ç., Mesut, B., Özsoy, Y., & Ocak, E. M. (2025). Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs). Journal of Research in Pharmacy, 25(5), 715-727. https://izlik.org/JA66RB85TF

AMA

1.Kazaz Ç, Mesut B, Özsoy Y, Ocak EM. Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs). J. Res. Pharm. 2025;25(5):715-727. https://izlik.org/JA66RB85TF

Chicago

Kazaz, Çağla, Burcu Mesut, Yıldız Özsoy, and Emine Meltem Ocak. 2025. “Formulation Development and Evaluation of Taste-Masked Atomoxetine Hydrochloride Orally Disintegrating Tablets (ODTs)”. Journal of Research in Pharmacy 25 (5): 715-27. https://izlik.org/JA66RB85TF.

EndNote

Kazaz Ç, Mesut B, Özsoy Y, Ocak EM (July 1, 2025) Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs). Journal of Research in Pharmacy 25 5 715–727.

IEEE

[1]Ç. Kazaz, B. Mesut, Y. Özsoy, and E. M. Ocak, “Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs)”, J. Res. Pharm., vol. 25, no. 5, pp. 715–727, July 2025, [Online]. Available: https://izlik.org/JA66RB85TF

ISNAD

Kazaz, Çağla - Mesut, Burcu - Özsoy, Yıldız - Ocak, Emine Meltem. “Formulation Development and Evaluation of Taste-Masked Atomoxetine Hydrochloride Orally Disintegrating Tablets (ODTs)”. Journal of Research in Pharmacy 25/5 (July 1, 2025): 715-727. https://izlik.org/JA66RB85TF.

JAMA

1.Kazaz Ç, Mesut B, Özsoy Y, Ocak EM. Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs). J. Res. Pharm. 2025;25:715–727.

MLA

Kazaz, Çağla, et al. “Formulation Development and Evaluation of Taste-Masked Atomoxetine Hydrochloride Orally Disintegrating Tablets (ODTs)”. Journal of Research in Pharmacy, vol. 25, no. 5, July 2025, pp. 715-27, https://izlik.org/JA66RB85TF.

Vancouver

1.Çağla Kazaz, Burcu Mesut, Yıldız Özsoy, Emine Meltem Ocak. Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs). J. Res. Pharm. [Internet]. 2025 Jul. 1;25(5):715-27. Available from: https://izlik.org/JA66RB85TF