Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

Oruç Yunusoğlu; Andleeb Shahzadi; Canan Akünal Türel; Muhammed Hamdi Demirkol; Mehmet Berköz; Ahmet Gökhan Akkan

Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

Abstract

Alcohol addiction is one of the leading causes which is associated with morbidity and mortality with outcomes in high healthcare and economic costs. Myricetin is a flavonoid that demonstrates therapeutic actions in many central nervous system diseases. In the current study, the conditioned place preference (CPP) tests were performed to examine the effects of myricetin on ethanol reward. During conditioning, intraperitoneal (i.p) administration of ethanol (2 g/kg) and serum physiologic were given on alternate days for 8 days. In order to evaluate the effect of myricetin on the development of alcohol addiction, myricetin was injected into mice 30 minutes before ethanol administration. Subsequently, a daily myricetin injection was performed to evaluate the effect of myricetin on the extinction of alcohol addiction. Finally, ethanol was administered 900 seconds after different dose myricetin administration, and reinstatement was evaluated immediately thereafter. Systemic ethanol (2 g/kg, i.p) administration significantly produced CPP. Myricetin (5 and 10 mg/kg, i.p) attenuated the development of ethanol addiction (p < 0.05). Systemic myricetin injections immediately after each extinction period precipitated extinction and decreased reinstatement (10 mg/kg, i.p, p < 0.05, respectively). Ethanol alone and in combination with myricetin did not change locomotor activity and motor coordination. As a result, it can be suggested that myricetin is effective in attenuating the rewarding effect of alcohol in mice and can be used for the adjunctive therapy for alcohol addiction. In addition, it will be appropriate to conduct mechanistic experimental studies regarding these results in the future.

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Research Article

Authors

Oruç Yunusoğlu ^*
0000-0003-1075-9574
Türkiye

Andleeb Shahzadi
0000-0002-2774-2325
Türkiye

Canan Akünal Türel
0000-0001-8791-235X
Türkiye

Muhammed Hamdi Demirkol This is me
0000-0001-8210-9701
Türkiye

Mehmet Berköz
0000-0003-4219-8054
Türkiye

Ahmet Gökhan Akkan
0000-0002-6799-1721
Türkiye

Publication Date

June 28, 2025

Submission Date

March 13, 2022

Acceptance Date

May 19, 2022

Published in Issue

Year 2022 Volume: 26 Number: 4

IZ

https://izlik.org/JA62AP42WL

Cite

RIS / Bibtex

APA

Yunusoğlu, O., Shahzadi, A., Akünal Türel, C., Demirkol, M. H., Berköz, M., & Akkan, A. G. (2025). Investigation of the pharmacological potential of myricetin on alcohol addiction in mice. Journal of Research in Pharmacy, 26(4), 722-733. https://izlik.org/JA62AP42WL

AMA

1.Yunusoğlu O, Shahzadi A, Akünal Türel C, Demirkol MH, Berköz M, Akkan AG. Investigation of the pharmacological potential of myricetin on alcohol addiction in mice. J. Res. Pharm. 2025;26(4):722-733. https://izlik.org/JA62AP42WL

Chicago

Yunusoğlu, Oruç, Andleeb Shahzadi, Canan Akünal Türel, Muhammed Hamdi Demirkol, Mehmet Berköz, and Ahmet Gökhan Akkan. 2025. “Investigation of the Pharmacological Potential of Myricetin on Alcohol Addiction in Mice”. Journal of Research in Pharmacy 26 (4): 722-33. https://izlik.org/JA62AP42WL.

EndNote

Yunusoğlu O, Shahzadi A, Akünal Türel C, Demirkol MH, Berköz M, Akkan AG (June 1, 2025) Investigation of the pharmacological potential of myricetin on alcohol addiction in mice. Journal of Research in Pharmacy 26 4 722–733.

IEEE

[1]O. Yunusoğlu, A. Shahzadi, C. Akünal Türel, M. H. Demirkol, M. Berköz, and A. G. Akkan, “Investigation of the pharmacological potential of myricetin on alcohol addiction in mice”, J. Res. Pharm., vol. 26, no. 4, pp. 722–733, June 2025, [Online]. Available: https://izlik.org/JA62AP42WL

ISNAD

Yunusoğlu, Oruç - Shahzadi, Andleeb - Akünal Türel, Canan - Demirkol, Muhammed Hamdi - Berköz, Mehmet - Akkan, Ahmet Gökhan. “Investigation of the Pharmacological Potential of Myricetin on Alcohol Addiction in Mice”. Journal of Research in Pharmacy 26/4 (June 1, 2025): 722-733. https://izlik.org/JA62AP42WL.

JAMA

1.Yunusoğlu O, Shahzadi A, Akünal Türel C, Demirkol MH, Berköz M, Akkan AG. Investigation of the pharmacological potential of myricetin on alcohol addiction in mice. J. Res. Pharm. 2025;26:722–733.

MLA

Yunusoğlu, Oruç, et al. “Investigation of the Pharmacological Potential of Myricetin on Alcohol Addiction in Mice”. Journal of Research in Pharmacy, vol. 26, no. 4, June 2025, pp. 722-33, https://izlik.org/JA62AP42WL.

Vancouver

1.Oruç Yunusoğlu, Andleeb Shahzadi, Canan Akünal Türel, Muhammed Hamdi Demirkol, Mehmet Berköz, Ahmet Gökhan Akkan. Investigation of the pharmacological potential of myricetin on alcohol addiction in mice. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(4):722-33. Available from: https://izlik.org/JA62AP42WL