Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

Year 2022, Volume: 26 Issue: 4, 722 - 733, 28.06.2025

Oruç Yunusoğlu , Andleeb Shahzadi , Canan Akünal Türel , Muhammed Hamdi Demirkol Mehmet Berköz , Ahmet Gökhan Akkan

https://izlik.org/JA62AP42WL

Abstract

Alcohol addiction is one of the leading causes which is associated with morbidity and mortality
with outcomes in high healthcare and economic costs. Myricetin is a flavonoid that demonstrates
therapeutic actions in many central nervous system diseases. In the current study, the conditioned place
preference (CPP) tests were performed to examine the effects of myricetin on ethanol reward. During
conditioning, intraperitoneal (i.p) administration of ethanol (2 g/kg) and serum physiologic were given on
alternate days for 8 days. In order to evaluate the effect of myricetin on the development of alcohol
addiction, myricetin was injected into mice 30 minutes before ethanol administration. Subsequently, a daily
myricetin injection was performed to evaluate the effect of myricetin on the extinction of alcohol addiction.
Finally, ethanol was administered 900 seconds after different dose myricetin administration, and
reinstatement was evaluated immediately thereafter. Systemic ethanol (2 g/kg, i.p) administration
significantly produced CPP. Myricetin (5 and 10 mg/kg, i.p) attenuated the development of ethanol
addiction (p < 0.05). Systemic myricetin injections immediately after each extinction period precipitated
extinction and decreased reinstatement (10 mg/kg, i.p, p < 0.05, respectively). Ethanol alone and in
combination with myricetin did not change locomotor activity and motor coordination. As a result, it can
be suggested that myricetin is effective in attenuating the rewarding effect of alcohol in mice and can be
used for the adjunctive therapy for alcohol addiction. In addition, it will be appropriate to conduct
mechanistic experimental studies regarding these results in the future.

Keywords

Alcohol addiction , myricetin , conditioned place preference (CPP) , mice

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