The effects of N(1)-2,4-dihydroxybenzylidene-N-(4) hydroxybenzylidene-S-methyl-thiosemicarbazidatooxovanadium( IV) on testicular damage in streptozotocininduced diabetic rats

Sevim Tunalı; Tülay Bal Demirci; Bahri Ülküseven; Refiye Yanardağ

The effects of N(1)-2,4-dihydroxybenzylidene-N-(4) hydroxybenzylidene-S-methyl-thiosemicarbazidatooxovanadium( IV) on testicular damage in streptozotocininduced diabetic rats

Abstract

Diabetes mellitus (DM) is a serious metabolic disorder that has negative effects on male sexual and reproductive functions in humans and animals. The purpose of current research is to demonstrate the effect of N(1)-2,4- dihydroxybenzylidene-N(4)-2-hydroxybenzylidene-S-methyl-thiosemicarbazidato-oxovanadium(IV) (VOL) on testicular damage in male rats with streptozotocin (STZ)-induced diabetes. Male Swiss albino rats were randomly grouped as follows: Control (intact) group animals; control group animals given VOL (0.2 mM/kg/day) for 12 days; STZ-induced diabetic animals; diabetic animals given VOL group, at same dose and time. Experimental diabetes was induced with a single dose of 65 mg/kg intraperitoneal STZ injection. On day 12, overnight fasted animals were sacrificed and testis tissues (right and left) were collected and homogenized in 0.9 % saline. After centrifugation, protein levels and nonenzymatic parameters such as glutathione, lipid peroxidation, protein carbonyl, as well as the activities of alkaline phosphatase, myeloperoxidase and enzymatic antioxidants were determined. Based on the results obtained, VOL was shown to be a potentially beneficial compound in the amelioration of damaged testicular tissue of male diabetic rats after 12 days of administration. Our results suggest that VOL may be a promising candidate for the development of new generation antidiabetic drugs, and its administration to diabetic rats may be a suitable candidate in reducing testicular damage.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biochemistry

Journal Section

Research Article

Authors

Sevim Tunalı ^*
0000-0003-3363-1290
Türkiye

Tülay Bal Demirci
0000-0003-4663-2209
Türkiye

Bahri Ülküseven
0000-0001-6342-1505
Türkiye

Refiye Yanardağ
Türkiye

Publication Date

June 28, 2025

Submission Date

September 23, 2021

Acceptance Date

March 5, 2022

Published in Issue

Year 2022 Volume: 26 Number: 3

IZ

https://izlik.org/JA35WK76JW

Cite

RIS / Bibtex

APA

Tunalı, S., Demirci, T. B., Ülküseven, B., & Yanardağ, R. (2025). The effects of N(1)-2,4-dihydroxybenzylidene-N-(4) hydroxybenzylidene-S-methyl-thiosemicarbazidatooxovanadium( IV) on testicular damage in streptozotocininduced diabetic rats. Journal of Research in Pharmacy, 26(3), 675-686. https://izlik.org/JA35WK76JW

AMA

1.Tunalı S, Demirci TB, Ülküseven B, Yanardağ R. The effects of N(1)-2,4-dihydroxybenzylidene-N-(4) hydroxybenzylidene-S-methyl-thiosemicarbazidatooxovanadium( IV) on testicular damage in streptozotocininduced diabetic rats. J. Res. Pharm. 2025;26(3):675-686. https://izlik.org/JA35WK76JW

Chicago

Tunalı, Sevim, Tülay Bal Demirci, Bahri Ülküseven, and Refiye Yanardağ. 2025. “The Effects of N(1)-2,4-Dihydroxybenzylidene-N-(4) Hydroxybenzylidene-S-Methyl-Thiosemicarbazidatooxovanadium( IV) on Testicular Damage in Streptozotocininduced Diabetic Rats”. Journal of Research in Pharmacy 26 (3): 675-86. https://izlik.org/JA35WK76JW.

EndNote

Tunalı S, Demirci TB, Ülküseven B, Yanardağ R (June 1, 2025) The effects of N(1)-2,4-dihydroxybenzylidene-N-(4) hydroxybenzylidene-S-methyl-thiosemicarbazidatooxovanadium( IV) on testicular damage in streptozotocininduced diabetic rats. Journal of Research in Pharmacy 26 3 675–686.

IEEE

[1]S. Tunalı, T. B. Demirci, B. Ülküseven, and R. Yanardağ, “The effects of N(1)-2,4-dihydroxybenzylidene-N-(4) hydroxybenzylidene-S-methyl-thiosemicarbazidatooxovanadium( IV) on testicular damage in streptozotocininduced diabetic rats”, J. Res. Pharm., vol. 26, no. 3, pp. 675–686, June 2025, [Online]. Available: https://izlik.org/JA35WK76JW

ISNAD

Tunalı, Sevim - Demirci, Tülay Bal - Ülküseven, Bahri - Yanardağ, Refiye. “The Effects of N(1)-2,4-Dihydroxybenzylidene-N-(4) Hydroxybenzylidene-S-Methyl-Thiosemicarbazidatooxovanadium( IV) on Testicular Damage in Streptozotocininduced Diabetic Rats”. Journal of Research in Pharmacy 26/3 (June 1, 2025): 675-686. https://izlik.org/JA35WK76JW.

JAMA

1.Tunalı S, Demirci TB, Ülküseven B, Yanardağ R. The effects of N(1)-2,4-dihydroxybenzylidene-N-(4) hydroxybenzylidene-S-methyl-thiosemicarbazidatooxovanadium( IV) on testicular damage in streptozotocininduced diabetic rats. J. Res. Pharm. 2025;26:675–686.

MLA

Tunalı, Sevim, et al. “The Effects of N(1)-2,4-Dihydroxybenzylidene-N-(4) Hydroxybenzylidene-S-Methyl-Thiosemicarbazidatooxovanadium( IV) on Testicular Damage in Streptozotocininduced Diabetic Rats”. Journal of Research in Pharmacy, vol. 26, no. 3, June 2025, pp. 675-86, https://izlik.org/JA35WK76JW.

Vancouver

1.Sevim Tunalı, Tülay Bal Demirci, Bahri Ülküseven, Refiye Yanardağ. The effects of N(1)-2,4-dihydroxybenzylidene-N-(4) hydroxybenzylidene-S-methyl-thiosemicarbazidatooxovanadium( IV) on testicular damage in streptozotocininduced diabetic rats. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(3):675-86. Available from: https://izlik.org/JA35WK76JW