Comparison of Commercial Calendula officinalis L. Samples with Pharmacopeial Drug: Antiradical Activities and Chemical Profiles

Reza Chamansara; Romina Rashidfarokhi; Ezgi Ak-sakallı; Nesrin Öztinen; Müberra Koşar

Comparison of Commercial Calendula officinalis L. Samples with Pharmacopeial Drug: Antiradical Activities and Chemical Profiles

Abstract

Calendula officinalis L. (Asteraceae) is traditionally used as a potent anti-inflammatory medicinal plant. The commercial petal samples of marigold are mostly used as herbal tea for its sedative and oral health effects due to its anti-viral and anti-bacterial properties. Its significant pharmacological activities are linked to the presence of distinct classes of compounds, particularly phenolic compounds, carotenoids, volatile oil, terpenoids and flavonoids. Taking into consideration that the amount and type of constituents could be variable in the commercial samples provided from Cyprus and Turkey compared to the standard due to various factors such as ecosystem and climate, time of harvesting, drying procedure and soil type, in this article the quality and safety of market samples was determined while ethanol and hexane extracts of standard and commercial C. officinalis samples were investigated for their anti-radical activity using ABTS and DPPH method. They both demonstrated dose-dependent manner anti-radical activity, further investigation by TPC (Total Phenolics Content) and HPLC provided evidence that both commercial and standard samples present similar fingerprint in terms of composition, and the total phenol equivalent to Gallic acid is not significantly different (P<0.05); therefore, both samples can be considered to be good and safe antiradical candidates used alternatively with the pharmacopeial drug.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Sciences

Journal Section

Research Article

Authors

Reza Chamansara This is me
0000-0002-7545-2795
Türkiye

Romina Rashidfarokhi This is me
0000-0002-9174-8940
Türkiye

Ezgi Ak-sakallı
0000-0002-0292-267X
Türkiye

Nesrin Öztinen
0000-0002-1517-6784
Türkiye

Müberra Koşar ^*
0000-0002-1559-998X
Türkiye

Publication Date

June 28, 2025

Submission Date

January 17, 2022

Acceptance Date

April 13, 2022

Published in Issue

Year 2022 Volume: 26 Number: 4

IZ

https://izlik.org/JA44KX87AP

Cite

RIS / Bibtex

APA

Chamansara, R., Rashidfarokhi, R., Ak-sakallı, E., Öztinen, N., & Koşar, M. (2025). Comparison of Commercial Calendula officinalis L. Samples with Pharmacopeial Drug: Antiradical Activities and Chemical Profiles. Journal of Research in Pharmacy, 26(4), 809-819. https://izlik.org/JA44KX87AP

AMA

1.Chamansara R, Rashidfarokhi R, Ak-sakallı E, Öztinen N, Koşar M. Comparison of Commercial Calendula officinalis L. Samples with Pharmacopeial Drug: Antiradical Activities and Chemical Profiles. J. Res. Pharm. 2025;26(4):809-819. https://izlik.org/JA44KX87AP

Chicago

Chamansara, Reza, Romina Rashidfarokhi, Ezgi Ak-sakallı, Nesrin Öztinen, and Müberra Koşar. 2025. “Comparison of Commercial Calendula Officinalis L. Samples With Pharmacopeial Drug: Antiradical Activities and Chemical Profiles”. Journal of Research in Pharmacy 26 (4): 809-19. https://izlik.org/JA44KX87AP.

EndNote

Chamansara R, Rashidfarokhi R, Ak-sakallı E, Öztinen N, Koşar M (June 1, 2025) Comparison of Commercial Calendula officinalis L. Samples with Pharmacopeial Drug: Antiradical Activities and Chemical Profiles. Journal of Research in Pharmacy 26 4 809–819.

IEEE

[1]R. Chamansara, R. Rashidfarokhi, E. Ak-sakallı, N. Öztinen, and M. Koşar, “Comparison of Commercial Calendula officinalis L. Samples with Pharmacopeial Drug: Antiradical Activities and Chemical Profiles”, J. Res. Pharm., vol. 26, no. 4, pp. 809–819, June 2025, [Online]. Available: https://izlik.org/JA44KX87AP

ISNAD

Chamansara, Reza - Rashidfarokhi, Romina - Ak-sakallı, Ezgi - Öztinen, Nesrin - Koşar, Müberra. “Comparison of Commercial Calendula Officinalis L. Samples With Pharmacopeial Drug: Antiradical Activities and Chemical Profiles”. Journal of Research in Pharmacy 26/4 (June 1, 2025): 809-819. https://izlik.org/JA44KX87AP.

JAMA

1.Chamansara R, Rashidfarokhi R, Ak-sakallı E, Öztinen N, Koşar M. Comparison of Commercial Calendula officinalis L. Samples with Pharmacopeial Drug: Antiradical Activities and Chemical Profiles. J. Res. Pharm. 2025;26:809–819.

MLA

Chamansara, Reza, et al. “Comparison of Commercial Calendula Officinalis L. Samples With Pharmacopeial Drug: Antiradical Activities and Chemical Profiles”. Journal of Research in Pharmacy, vol. 26, no. 4, June 2025, pp. 809-1, https://izlik.org/JA44KX87AP.

Vancouver

1.Reza Chamansara, Romina Rashidfarokhi, Ezgi Ak-sakallı, Nesrin Öztinen, Müberra Koşar. Comparison of Commercial Calendula officinalis L. Samples with Pharmacopeial Drug: Antiradical Activities and Chemical Profiles. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(4):809-1. Available from: https://izlik.org/JA44KX87AP