Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization

Prabhu Halakatti; Shrinivas R. Danti; Anita R. Desai; Mallappa Shalavadi; Naveenkumar Mulabeli; Mahantesh Patted

Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization

Abstract

The aim of present work is to formulate and characterize the Vildagliptin (VLD) loaded polymeric nanoparticles for the treatment of type II diabetes mellitus. Polymeric nanoparticles were prepared by ionotropic gelation method with sodium tripolyphosphate (STPP) as a cross linkers. The obtained sample of VLD was evaluated by UV and FT-IR studies. Prepared polymeric nanoparticles were characterized in term of drug-polymer intraction, particle size and polydispersity index (PDI), zeta potential, % drug content (DC), % drug entrapment efficiency (DEE) and scanning electron microscopy (SEM). In vitro and in vivo drug release studies were also performed. FT-IR study showed that drug and polymers are compatible with each other and cross-linking was observed between chitosan and STPP. Particle size was range from 238.2 nm to 708.8nm for all the formulations. Zeta potential was range from-8.49mV to 11.1mV. %DC range from68.12% to 84.37%, and % DEE was range from 78.76% to 93.91%. SEM images showed that the prepared formulations were smooth and spherical. In vitro drug release evaluation in phosphate buffer pH 7.4 showed sustained release pattern, i.e. 55.17% to 62.89% within 12hours. The data were fitted to Korsmeyer-Peppas model which showed fickian diffusion as a predominant release mechanism. In vivo drug release evalutionshowed significant decrease in the blood glucose level. Thus, conclude that prepared polymeric nanoparticles by ionotropic gelation method have a sustain release pattern and incresesstabilty of drug.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Prabhu Halakatti ^*
0000-0003-2300-9692
India

Shrinivas R. Danti This is me
0000-0001-5612-035X
India

Anita R. Desai This is me
0000-0003-1032-2604
India

Mallappa Shalavadi
0000-0002-7496-6372
India

Naveenkumar Mulabeli This is me
0000-0001-8271-0820
Indonesia

Mahantesh Patted This is me
0000-0002-7940-4803
India

Publication Date

June 28, 2025

Submission Date

November 14, 2022

Acceptance Date

April 11, 2024

Published in Issue

Year 2024 Volume: 28 Number: 5

IZ

https://izlik.org/JA95YP78WW

Cite

RIS / Bibtex

APA

Halakatti, P., Danti, S. R., Desai, A. R., Shalavadi, M., Mulabeli, N., & Patted, M. (2025). Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization. Journal of Research in Pharmacy, 28(5), 1423-1434. https://izlik.org/JA95YP78WW

AMA

1.Halakatti P, Danti SR, Desai AR, Shalavadi M, Mulabeli N, Patted M. Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization. J. Res. Pharm. 2025;28(5):1423-1434. https://izlik.org/JA95YP78WW

Chicago

Halakatti, Prabhu, Shrinivas R. Danti, Anita R. Desai, Mallappa Shalavadi, Naveenkumar Mulabeli, and Mahantesh Patted. 2025. “Vildagliptin Loaded Polymeric Nanoparticles Using Cross-Linked Polymer by Ionotropic Gelation Method: Development and Characterization”. Journal of Research in Pharmacy 28 (5): 1423-34. https://izlik.org/JA95YP78WW.

EndNote

Halakatti P, Danti SR, Desai AR, Shalavadi M, Mulabeli N, Patted M (July 1, 2025) Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization. Journal of Research in Pharmacy 28 5 1423–1434.

IEEE

[1]P. Halakatti, S. R. Danti, A. R. Desai, M. Shalavadi, N. Mulabeli, and M. Patted, “Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization”, J. Res. Pharm., vol. 28, no. 5, pp. 1423–1434, July 2025, [Online]. Available: https://izlik.org/JA95YP78WW

ISNAD

Halakatti, Prabhu - Danti, Shrinivas R. - Desai, Anita R. - Shalavadi, Mallappa - Mulabeli, Naveenkumar - Patted, Mahantesh. “Vildagliptin Loaded Polymeric Nanoparticles Using Cross-Linked Polymer by Ionotropic Gelation Method: Development and Characterization”. Journal of Research in Pharmacy 28/5 (July 1, 2025): 1423-1434. https://izlik.org/JA95YP78WW.

JAMA

1.Halakatti P, Danti SR, Desai AR, Shalavadi M, Mulabeli N, Patted M. Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization. J. Res. Pharm. 2025;28:1423–1434.

MLA

Halakatti, Prabhu, et al. “Vildagliptin Loaded Polymeric Nanoparticles Using Cross-Linked Polymer by Ionotropic Gelation Method: Development and Characterization”. Journal of Research in Pharmacy, vol. 28, no. 5, July 2025, pp. 1423-34, https://izlik.org/JA95YP78WW.

Vancouver

1.Prabhu Halakatti, Shrinivas R. Danti, Anita R. Desai, Mallappa Shalavadi, Naveenkumar Mulabeli, Mahantesh Patted. Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization. J. Res. Pharm. [Internet]. 2025 Jul. 1;28(5):1423-34. Available from: https://izlik.org/JA95YP78WW