Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel

Noorma Rosita; Dewı Harıyadı; Cordellia Calista Amelia; Alyajilan Madani Mamurrie; Andang Miatmoko

Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel

Abstract

A gel with mucoadhesive properties and a controlled release profile is a suitable dosage form for reverse micellar EGCG delivery. In this study, ĸ-Carrageenan and HPMC K100M were used as the gel components at a weight ratio of 1:1.5, respectively, for loading native and reverse micellar EGCG. The characteristics of the gel were determined based on pH, swelling index, disintegration time, hardness, and entrapment efficiency. The in vitro EGCG release rate was further determined for EGCG levels. Moreover, in vivo cervical penetration studies of rhodamine-labeled EGCG gels in mice at two and six hours after intravaginal administrations were conducted. The results showed that the pH and hardness characteristics of the gels for each formula did not differ significantly, while the gel-loaded reverse micellar EGCG had a higher swelling index than that of native EGCG gels. In addition, the rate of release and cervical penetration of rhodamine-labeled reverse micellar EGCG loaded in gels was higher than those of rhodamine-labeled native EGCG gels. Therefore, it can be concluded that loading reverse micelles EGCG into gels prepared with ĸ- Carrageenan and HPMC K100M successfully controlled the release rate and improved cervical penetration, thereby enabling its potential use in cervical cancer treatment.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Sciences

Journal Section

Research Article

Authors

Noorma Rosita ^*
0000-0003-1048-0899
Indonesia

Dewı Harıyadı
0000-0001-9357-3913
Indonesia

Cordellia Calista Amelia This is me
0000-0001-6433-135X
Indonesia

Alyajilan Madani Mamurrie This is me
0000-0003-2893-9653
Indonesia

Andang Miatmoko This is me
0000-0003-1658-0778
Indonesia

Publication Date

June 28, 2025

Submission Date

January 14, 2022

Acceptance Date

April 22, 2022

Published in Issue

Year 2022 Volume: 26 Number: 4

IZ

https://izlik.org/JA82LP72NG

Cite

RIS / Bibtex

APA

Rosita, N., Harıyadı, D., Amelia, C. C., Mamurrie, A. M., & Miatmoko, A. (2025). Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel. Journal of Research in Pharmacy, 26(4), 849-858. https://izlik.org/JA82LP72NG

AMA

1.Rosita N, Harıyadı D, Amelia CC, Mamurrie AM, Miatmoko A. Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel. J. Res. Pharm. 2025;26(4):849-858. https://izlik.org/JA82LP72NG

Chicago

Rosita, Noorma, Dewı Harıyadı, Cordellia Calista Amelia, Alyajilan Madani Mamurrie, and Andang Miatmoko. 2025. “Intravaginal Delivery of Reverse Micellar Epigallocatechin Loaded in ĸ-Carrageenan and HPMC K100M-Based Gel”. Journal of Research in Pharmacy 26 (4): 849-58. https://izlik.org/JA82LP72NG.

EndNote

Rosita N, Harıyadı D, Amelia CC, Mamurrie AM, Miatmoko A (June 1, 2025) Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel. Journal of Research in Pharmacy 26 4 849–858.

IEEE

[1]N. Rosita, D. Harıyadı, C. C. Amelia, A. M. Mamurrie, and A. Miatmoko, “Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel”, J. Res. Pharm., vol. 26, no. 4, pp. 849–858, June 2025, [Online]. Available: https://izlik.org/JA82LP72NG

ISNAD

Rosita, Noorma - Harıyadı, Dewı - Amelia, Cordellia Calista - Mamurrie, Alyajilan Madani - Miatmoko, Andang. “Intravaginal Delivery of Reverse Micellar Epigallocatechin Loaded in ĸ-Carrageenan and HPMC K100M-Based Gel”. Journal of Research in Pharmacy 26/4 (June 1, 2025): 849-858. https://izlik.org/JA82LP72NG.

JAMA

1.Rosita N, Harıyadı D, Amelia CC, Mamurrie AM, Miatmoko A. Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel. J. Res. Pharm. 2025;26:849–858.

MLA

Rosita, Noorma, et al. “Intravaginal Delivery of Reverse Micellar Epigallocatechin Loaded in ĸ-Carrageenan and HPMC K100M-Based Gel”. Journal of Research in Pharmacy, vol. 26, no. 4, June 2025, pp. 849-58, https://izlik.org/JA82LP72NG.

Vancouver

1.Noorma Rosita, Dewı Harıyadı, Cordellia Calista Amelia, Alyajilan Madani Mamurrie, Andang Miatmoko. Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(4):849-58. Available from: https://izlik.org/JA82LP72NG