Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam

Afife Büşra Uğur Kaplan; Büşra Kandilli; Meltem Çetin; Fatma Demirkaya Miloğlu

Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam

Abstract

The purpose of the present study was to prepare only levetiracetam (LEV) or carbamazepine (CBZ) or their combination (LEV+CBZ)-loaded alginate (AL) beads for oral administration to treat epilepsy and to evaluate their in vitro characteristics. AL beads were prepared using ionotropic gelation method and lyophilized. The bead formulations were evaluated for particles size, surface morphology, encapsulation efficiency and in vitro drug release in PB pH 6.8 and HCl pH 1.2 release mediums. FT-IR was also used to characterize the beads. The mean particle sizes of wet and lyophilized AL beads were in range of 1.609±0.073-1.779±0.078 mm and 1.075±0.182-1.275±0.138 mm, respectively. The encapsulation efficiency (EE%) values of bead formulations were in the range of 18.74-24.65% for LEV and 90.36-94.03% for CBZ. The pH of the medium affects the swelling behaviours of AL beads and the degree of swelling of AL beads increased with increase of pH of release medium, due to exchange of the Ca2+ ion with Na+. Besides, the pH of the release medium and the high water solubility of LEV affected the drug release rate from beads. AL beads might be useful to use for oral administration of LEV and CBZ to obtain additive/synergistic effect in a combined treatment of epilepsy.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Analytical Chemistry, Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Afife Büşra Uğur Kaplan
Türkiye

Büşra Kandilli This is me
Türkiye

Meltem Çetin ^*
Türkiye

Fatma Demirkaya Miloğlu
Türkiye

Publication Date

June 27, 2025

Submission Date

September 26, 2018

Acceptance Date

November 22, 2018

Published in Issue

Year 2019 Volume: 23 Number: 4

IZ

https://izlik.org/JA78EU83KC

Cite

RIS / Bibtex

APA

Uğur Kaplan, A. B., Kandilli, B., Çetin, M., & Demirkaya Miloğlu, F. (2025). Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam. Journal of Research in Pharmacy, 23(4), 642-651. https://izlik.org/JA78EU83KC

AMA

1.Uğur Kaplan AB, Kandilli B, Çetin M, Demirkaya Miloğlu F. Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam. J. Res. Pharm. 2025;23(4):642-651. https://izlik.org/JA78EU83KC

Chicago

Uğur Kaplan, Afife Büşra, Büşra Kandilli, Meltem Çetin, and Fatma Demirkaya Miloğlu. 2025. “Preparation and in Vitro Characterization of AL-Beads Containing Carbamazepine and Or Levetiracetam”. Journal of Research in Pharmacy 23 (4): 642-51. https://izlik.org/JA78EU83KC.

EndNote

Uğur Kaplan AB, Kandilli B, Çetin M, Demirkaya Miloğlu F (June 1, 2025) Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam. Journal of Research in Pharmacy 23 4 642–651.

IEEE

[1]A. B. Uğur Kaplan, B. Kandilli, M. Çetin, and F. Demirkaya Miloğlu, “Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam”, J. Res. Pharm., vol. 23, no. 4, pp. 642–651, June 2025, [Online]. Available: https://izlik.org/JA78EU83KC

ISNAD

Uğur Kaplan, Afife Büşra - Kandilli, Büşra - Çetin, Meltem - Demirkaya Miloğlu, Fatma. “Preparation and in Vitro Characterization of AL-Beads Containing Carbamazepine and Or Levetiracetam”. Journal of Research in Pharmacy 23/4 (June 1, 2025): 642-651. https://izlik.org/JA78EU83KC.

JAMA

1.Uğur Kaplan AB, Kandilli B, Çetin M, Demirkaya Miloğlu F. Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam. J. Res. Pharm. 2025;23:642–651.

MLA

Uğur Kaplan, Afife Büşra, et al. “Preparation and in Vitro Characterization of AL-Beads Containing Carbamazepine and Or Levetiracetam”. Journal of Research in Pharmacy, vol. 23, no. 4, June 2025, pp. 642-51, https://izlik.org/JA78EU83KC.

Vancouver

1.Afife Büşra Uğur Kaplan, Büşra Kandilli, Meltem Çetin, Fatma Demirkaya Miloğlu. Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(4):642-51. Available from: https://izlik.org/JA78EU83KC