Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones

Kübra Demir-yazıcı; Özlen Güzel Akdemir

Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones

Abstract

In our pursuit to discover new anticancer agents, we have synthesized a new series of 2-aryl-1,3- thiazolidin-4-one derivatives carrying a mandelic acid part. Compounds 3a-h and 4a-j have been synthesized with the cyclization of mandelic acid-derived Schiff bases, their structures have been elucidated with spectral methods (1H-NMR, 13C-NMR, and LC/MS-APCI) and elemental analyzes (C, H, N). Five compounds 3d, 3e, 4e, 4f, and 4g chosen as prototypes were evaluated against the full panel of 58 human tumor cell lines in the National Cancer Institute’s in vitro primary cytotoxicity assay (Bethesda, Maryland). Among the tested compound, 3e showed good cytotoxic effects against melanoma cell line UACC-62. Compounds 3d, 4e, 4f, and 4g showed moderate cytotoxic effects, especially against leukemia cell line, RPMI-8226, non-small cell lung cancer cell lines NCI-H23 and HOP-92, central nervous system (CNS) cancer cell lines SF-295 and SNB-75, melanoma cell line UACC-62, and ovarian cancer cell line IGROV1. It is considered that the in vitro test results of selected compounds are promising and an additional mandelic acid moiety to core structure 2-aryl-1,3-thiazolidin-4-one and different modifications may result in effective agents in anticancer treatment.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Kübra Demir-yazıcı
0000-0001-9928-4733
Türkiye

Özlen Güzel Akdemir ^*
0000-0003-3680-1945
Türkiye

Publication Date

June 28, 2025

Submission Date

February 11, 2022

Acceptance Date

April 4, 2022

Published in Issue

Year 2022 Volume: 26 Number: 4

IZ

https://izlik.org/JA45GX62LJ

Cite

RIS / Bibtex

APA

Demir-yazıcı, K., & Güzel Akdemir, Ö. (2025). Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. Journal of Research in Pharmacy, 26(4), 931-940. https://izlik.org/JA45GX62LJ

AMA

1.Demir-yazıcı K, Güzel Akdemir Ö. Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. J. Res. Pharm. 2025;26(4):931-940. https://izlik.org/JA45GX62LJ

Chicago

Demir-yazıcı, Kübra, and Özlen Güzel Akdemir. 2025. “Synthesis and Potential Antitumor Activities of Mandelic Acid Linked 2-Aryl-1,3-Thiazolidin-4-Ones”. Journal of Research in Pharmacy 26 (4): 931-40. https://izlik.org/JA45GX62LJ.

EndNote

Demir-yazıcı K, Güzel Akdemir Ö (June 1, 2025) Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. Journal of Research in Pharmacy 26 4 931–940.

IEEE

[1]K. Demir-yazıcı and Ö. Güzel Akdemir, “Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones”, J. Res. Pharm., vol. 26, no. 4, pp. 931–940, June 2025, [Online]. Available: https://izlik.org/JA45GX62LJ

ISNAD

Demir-yazıcı, Kübra - Güzel Akdemir, Özlen. “Synthesis and Potential Antitumor Activities of Mandelic Acid Linked 2-Aryl-1,3-Thiazolidin-4-Ones”. Journal of Research in Pharmacy 26/4 (June 1, 2025): 931-940. https://izlik.org/JA45GX62LJ.

JAMA

1.Demir-yazıcı K, Güzel Akdemir Ö. Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. J. Res. Pharm. 2025;26:931–940.

MLA

Demir-yazıcı, Kübra, and Özlen Güzel Akdemir. “Synthesis and Potential Antitumor Activities of Mandelic Acid Linked 2-Aryl-1,3-Thiazolidin-4-Ones”. Journal of Research in Pharmacy, vol. 26, no. 4, June 2025, pp. 931-40, https://izlik.org/JA45GX62LJ.

Vancouver

1.Kübra Demir-yazıcı, Özlen Güzel Akdemir. Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(4):931-40. Available from: https://izlik.org/JA45GX62LJ