The Cytotoxicity and the Antimicrobial Activities of Arum italicum Miller

Melek Ulusoylu-dumlu; Burçak Gürbüz

The Cytotoxicity and the Antimicrobial Activities of Arum italicum Miller

Abstract

In this study, the cytotoxicity potential and antibacterial and antifungal activities of two different extracts of fresh leaves of Arum italicum Miller were investigated. The saponin extract and the alkaloid extract were investigated by Brine Shrimp (Artemia salina L.) lethality bioassay method for evaluation of cytotoxic effect. Umbelliferone was used as standard, and both of the extracts showed cytotoxic effect by the Brine Shrimp (Artemia salina L.) lethality bioassay method. According to the LC50 results, saponin extract was found to be the most active extract, and classifiable as moderate to highly toxic (LC50 237.1437 mg/mL-1). Although, the alkaloid extract was showed cytotoxic activity lower than Umbelliferone, LC50 750.1920 mg/mL-1 value was classifiable as mildly cytotoxic. Antibacterial and antifungal activities were tested by the agar well diffusion and tube dilution methods. 6 bacteria and 6 yeasts were used in the methods Meropenem and Fluconazole were the standards of the methods. The saponin extract was found to be effective against Staphylococcus epidermidis and Sthaphylococcus aureus compared with Meropenem. Both of the extracts were not found to be effective against fluconazole as antifungal activity point of view. According to the all studied activity results the saponin contents of the fresh leaves of the plant emphasizing the antimicrobial activity. And, both of the extracts have cytotoxic activity potential.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Microbiology

Journal Section

Research Article

Authors

Melek Ulusoylu-dumlu ^*
0000-0002-4787-3648
Türkiye

Burçak Gürbüz
0000-0002-1002-8264
Türkiye

Publication Date

June 28, 2025

Submission Date

April 22, 2022

Acceptance Date

May 20, 2022

Published in Issue

Year 2022 Volume: 26 Number: 4

IZ

https://izlik.org/JA54LZ49UR

Cite

RIS / Bibtex

APA

Ulusoylu-dumlu, M., & Gürbüz, B. (2025). The Cytotoxicity and the Antimicrobial Activities of Arum italicum Miller. Journal of Research in Pharmacy, 26(4), 992-996. https://izlik.org/JA54LZ49UR

AMA

1.Ulusoylu-dumlu M, Gürbüz B. The Cytotoxicity and the Antimicrobial Activities of Arum italicum Miller. J. Res. Pharm. 2025;26(4):992-996. https://izlik.org/JA54LZ49UR

Chicago

Ulusoylu-dumlu, Melek, and Burçak Gürbüz. 2025. “The Cytotoxicity and the Antimicrobial Activities of Arum Italicum Miller”. Journal of Research in Pharmacy 26 (4): 992-96. https://izlik.org/JA54LZ49UR.

EndNote

Ulusoylu-dumlu M, Gürbüz B (June 1, 2025) The Cytotoxicity and the Antimicrobial Activities of Arum italicum Miller. Journal of Research in Pharmacy 26 4 992–996.

IEEE

[1]M. Ulusoylu-dumlu and B. Gürbüz, “The Cytotoxicity and the Antimicrobial Activities of Arum italicum Miller”, J. Res. Pharm., vol. 26, no. 4, pp. 992–996, June 2025, [Online]. Available: https://izlik.org/JA54LZ49UR

ISNAD

Ulusoylu-dumlu, Melek - Gürbüz, Burçak. “The Cytotoxicity and the Antimicrobial Activities of Arum Italicum Miller”. Journal of Research in Pharmacy 26/4 (June 1, 2025): 992-996. https://izlik.org/JA54LZ49UR.

JAMA

1.Ulusoylu-dumlu M, Gürbüz B. The Cytotoxicity and the Antimicrobial Activities of Arum italicum Miller. J. Res. Pharm. 2025;26:992–996.

MLA

Ulusoylu-dumlu, Melek, and Burçak Gürbüz. “The Cytotoxicity and the Antimicrobial Activities of Arum Italicum Miller”. Journal of Research in Pharmacy, vol. 26, no. 4, June 2025, pp. 992-6, https://izlik.org/JA54LZ49UR.

Vancouver

1.Melek Ulusoylu-dumlu, Burçak Gürbüz. The Cytotoxicity and the Antimicrobial Activities of Arum italicum Miller. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(4):992-6. Available from: https://izlik.org/JA54LZ49UR