Formulation, stability and analytical method validation of chasteberry (Vitex agnus-castus L.) extract in solid oral dosage forms

İlker Demirbolat; Murat Kartal

Formulation, stability and analytical method validation of chasteberry (Vitex agnus-castus L.) extract in solid oral dosage forms

Abstract

Premenstrual syndrome (PMS) is a common condition that affects 90% of menstruating women on emotions, behaviours and physical health. Vitex agnus-castus L. also known as chasteberry or chaste tree is long being used for its health benefits on feminine problems like PMS and hyperprolactinemia. There are also some prescription medicines to ease the symptoms of PMS. While dietary supplements containing medicinal plants could be found everywhere with the lack of quality and standardisation, there are only a few registered traditional herbal medicinal products available on the market containing agnus-castus fruit extract. In this study we developed a stable film coated oral formulation and fully validated the analytical methods to quantify the extract in dosage forms to fulfil the requirements of CTD module 3 while registering the traditional herbal medicinal product according to European Union legislations.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Botany, Pharmaceutical Chemistry

Journal Section

Research Article

Authors

İlker Demirbolat ^* This is me
Türkiye

Murat Kartal
Türkiye

Publication Date

June 27, 2025

Submission Date

March 18, 2019

Acceptance Date

April 25, 2019

Published in Issue

Year 2019 Volume: 23 Number: 4

IZ

https://izlik.org/JA22BX72XE

Cite

RIS / Bibtex

APA

Demirbolat, İ., & Kartal, M. (2025). Formulation, stability and analytical method validation of chasteberry (Vitex agnus-castus L.) extract in solid oral dosage forms. Journal of Research in Pharmacy, 23(4), 689-696. https://izlik.org/JA22BX72XE

AMA

1.Demirbolat İ, Kartal M. Formulation, stability and analytical method validation of chasteberry (Vitex agnus-castus L.) extract in solid oral dosage forms. J. Res. Pharm. 2025;23(4):689-696. https://izlik.org/JA22BX72XE

Chicago

Demirbolat, İlker, and Murat Kartal. 2025. “Formulation, Stability and Analytical Method Validation of Chasteberry (Vitex Agnus-Castus L.) Extract in Solid Oral Dosage Forms”. Journal of Research in Pharmacy 23 (4): 689-96. https://izlik.org/JA22BX72XE.

EndNote

Demirbolat İ, Kartal M (June 1, 2025) Formulation, stability and analytical method validation of chasteberry (Vitex agnus-castus L.) extract in solid oral dosage forms. Journal of Research in Pharmacy 23 4 689–696.

IEEE

[1]İ. Demirbolat and M. Kartal, “Formulation, stability and analytical method validation of chasteberry (Vitex agnus-castus L.) extract in solid oral dosage forms”, J. Res. Pharm., vol. 23, no. 4, pp. 689–696, June 2025, [Online]. Available: https://izlik.org/JA22BX72XE

ISNAD

Demirbolat, İlker - Kartal, Murat. “Formulation, Stability and Analytical Method Validation of Chasteberry (Vitex Agnus-Castus L.) Extract in Solid Oral Dosage Forms”. Journal of Research in Pharmacy 23/4 (June 1, 2025): 689-696. https://izlik.org/JA22BX72XE.

JAMA

1.Demirbolat İ, Kartal M. Formulation, stability and analytical method validation of chasteberry (Vitex agnus-castus L.) extract in solid oral dosage forms. J. Res. Pharm. 2025;23:689–696.

MLA

Demirbolat, İlker, and Murat Kartal. “Formulation, Stability and Analytical Method Validation of Chasteberry (Vitex Agnus-Castus L.) Extract in Solid Oral Dosage Forms”. Journal of Research in Pharmacy, vol. 23, no. 4, June 2025, pp. 689-96, https://izlik.org/JA22BX72XE.

Vancouver

1.İlker Demirbolat, Murat Kartal. Formulation, stability and analytical method validation of chasteberry (Vitex agnus-castus L.) extract in solid oral dosage forms. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(4):689-96. Available from: https://izlik.org/JA22BX72XE