High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin

Gülsün Memi; Levent Öztürk; Orkide Palabıyık

High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin

Abstract

The obese population has been rapidly increasing because of high-fat consumption and a sedentary lifestyle. Large amounts of dietary fat intake increase the risk of cardiovascular disease. We aimed to investigate the effects of exercise and obestatin on a high-fat diet (HFD) induced cardiac hemodynamic changes. Seventy-nine Sprague Dawley rats (200 to 250 g) were fed either control diet or HFD for 8 weeks. In the 5th week, each diet group was subgrouped as follows; control, exercise, obestatin (25μg/kg, i.p), exercise+obestatin (25μg/kg, i.p). After the end of 4 weeks of exercise (swimming exercise, 5 days a week/ 20 min day) and obestatin administration period, all animals were sacrificed. Hearts were removed for hemodynamic measurements with the Langendorff apparatus. Blood samples were collected for biochemical measurements. Data were analyzed by Graphpad Prism 6.0. and p<0.05 was accepted as statistically significant. Cardiac contractility and hemodynamic parameters in the HFD model have been evaluated. And the effects of chronic obestatin treatment and exercise were studied together. Obestatin ameliorated derangements in LVDP, heart rate, and blood lipid levels induced by an HFD. Also, obestatin prevents decreasing BNP levels with high fat consumption. Obestatin treatment potentiated the beneficial effects of exercise evidenced by LVDP, heart rate, blood lipids, BNP, and AT2R1 measurements. We believe that obestatin has the potential for the maintenance of cardiac function in HFD.

Keywords

References

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Details

Primary Language

English

Subjects

Medical Pharmacology

Journal Section

Research Article

Authors

Gülsün Memi ^*
0000-0002-4897-6307
Türkiye

Levent Öztürk
0000-0002-0182-3960
Türkiye

Orkide Palabıyık
0000-0002-3488-3740
Türkiye

Publication Date

June 28, 2025

Submission Date

August 25, 2022

Acceptance Date

September 21, 2022

Published in Issue

Year 2023 Volume: 27 Number: 1

IZ

https://izlik.org/JA52PC52WT

Cite

RIS / Bibtex

APA

Memi, G., Öztürk, L., & Palabıyık, O. (2025). High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin. Journal of Research in Pharmacy, 27(1), 404-413. https://izlik.org/JA52PC52WT

AMA

1.Memi G, Öztürk L, Palabıyık O. High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin. J. Res. Pharm. 2025;27(1):404-413. https://izlik.org/JA52PC52WT

Chicago

Memi, Gülsün, Levent Öztürk, and Orkide Palabıyık. 2025. “High-Fat Diet Induced Cardiac Hemodynamic Changes: Effects of Exercise and Obestatin”. Journal of Research in Pharmacy 27 (1): 404-13. https://izlik.org/JA52PC52WT.

EndNote

Memi G, Öztürk L, Palabıyık O (June 1, 2025) High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin. Journal of Research in Pharmacy 27 1 404–413.

IEEE

[1]G. Memi, L. Öztürk, and O. Palabıyık, “High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin”, J. Res. Pharm., vol. 27, no. 1, pp. 404–413, June 2025, [Online]. Available: https://izlik.org/JA52PC52WT

ISNAD

Memi, Gülsün - Öztürk, Levent - Palabıyık, Orkide. “High-Fat Diet Induced Cardiac Hemodynamic Changes: Effects of Exercise and Obestatin”. Journal of Research in Pharmacy 27/1 (June 1, 2025): 404-413. https://izlik.org/JA52PC52WT.

JAMA

1.Memi G, Öztürk L, Palabıyık O. High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin. J. Res. Pharm. 2025;27:404–413.

MLA

Memi, Gülsün, et al. “High-Fat Diet Induced Cardiac Hemodynamic Changes: Effects of Exercise and Obestatin”. Journal of Research in Pharmacy, vol. 27, no. 1, June 2025, pp. 404-13, https://izlik.org/JA52PC52WT.

Vancouver

1.Gülsün Memi, Levent Öztürk, Orkide Palabıyık. High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(1):404-13. Available from: https://izlik.org/JA52PC52WT