Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats

Dicle Karğın; Şule Aktaç; Figen Öztürk; Muhammet Emin Çam

Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats

Abstract

Cornelian cherry (Cornus mas L.) has been used for centuries as a traditional herbal medicine in Europe and Asia. In this study, we aimed to describe the effect of Cornus mas L. (C. mas) on the activity of the antioxidant enzymes and a detoxification agent in rats fed a high-fat diet. Forty-eight adult Sprague Dawley rats were randomly assigned to six groups of eight animals each: Standard diet (Control), High Fat Diet (HFD), HFD + C. mas (200 mg/kg/day; 8 weeks), HFD + Atorvastatin (20 mg/kg/day; 8 weeks), HFD post-treated with C. mas (200 mg/kg/day; 4 weeks), HFD post-treated with Atorvastatin (20 mg/kg/day; 4 weeks). The activity of the antioxidant enzymes, Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), detoxification agent glutathione (GSH), and oxidative stress parameter thiobarbituric acid reactive substances (TBARS) were measured in the liver tissues. GPx, SOD, and CAT enzyme levels were decreased in HFD groups compared to the control (p < 0.05). However, Cornus mas L. promoted antioxidant activity by increasing GPx, SOD, and CAT enzymes and It also reduced oxidative stress (as an increase in GSH) both in the HFD + C. mas group and the HFD post-treated C. mas group compared to the HFD group (p < 0.05). Our study showed that feeding a high-fat diet increases oxidative stress. Cornus mas L treatment improves antioxidant enzyme activity and oxidative stress parameters in the liver tissues of rats.

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Research Article

Authors

Dicle Karğın
0000-0002-7393-730X
Türkiye

Şule Aktaç
0000-0002-2158-5015
Türkiye

Figen Öztürk
0000-0001-6180-5716
Türkiye

Muhammet Emin Çam
0000-0001-5398-6801
Türkiye

Publication Date

June 28, 2025

Submission Date

November 28, 2022

Acceptance Date

December 22, 2022

Published in Issue

Year 2023 Volume: 27 Number: 1

IZ

https://izlik.org/JA65FD32WM

Cite

RIS / Bibtex

APA

Karğın, D., Aktaç, Ş., Öztürk, F., & Çam, M. E. (2025). Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats. Journal of Research in Pharmacy, 27(1), 432-440. https://izlik.org/JA65FD32WM

AMA

1.Karğın D, Aktaç Ş, Öztürk F, Çam ME. Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats. J. Res. Pharm. 2025;27(1):432-440. https://izlik.org/JA65FD32WM

Chicago

Karğın, Dicle, Şule Aktaç, Figen Öztürk, and Muhammet Emin Çam. 2025. “Effects of Cornus Mas L. On Lipid Peroxidation and Anti-Oxidative Enzyme Activity in High Fat Diet Fed Rats”. Journal of Research in Pharmacy 27 (1): 432-40. https://izlik.org/JA65FD32WM.

EndNote

Karğın D, Aktaç Ş, Öztürk F, Çam ME (June 1, 2025) Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats. Journal of Research in Pharmacy 27 1 432–440.

IEEE

[1]D. Karğın, Ş. Aktaç, F. Öztürk, and M. E. Çam, “Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats”, J. Res. Pharm., vol. 27, no. 1, pp. 432–440, June 2025, [Online]. Available: https://izlik.org/JA65FD32WM

ISNAD

Karğın, Dicle - Aktaç, Şule - Öztürk, Figen - Çam, Muhammet Emin. “Effects of Cornus Mas L. On Lipid Peroxidation and Anti-Oxidative Enzyme Activity in High Fat Diet Fed Rats”. Journal of Research in Pharmacy 27/1 (June 1, 2025): 432-440. https://izlik.org/JA65FD32WM.

JAMA

1.Karğın D, Aktaç Ş, Öztürk F, Çam ME. Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats. J. Res. Pharm. 2025;27:432–440.

MLA

Karğın, Dicle, et al. “Effects of Cornus Mas L. On Lipid Peroxidation and Anti-Oxidative Enzyme Activity in High Fat Diet Fed Rats”. Journal of Research in Pharmacy, vol. 27, no. 1, June 2025, pp. 432-40, https://izlik.org/JA65FD32WM.

Vancouver

1.Dicle Karğın, Şule Aktaç, Figen Öztürk, Muhammet Emin Çam. Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(1):432-40. Available from: https://izlik.org/JA65FD32WM