Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers?

Gülin Amasya Çelikten; Ömer Yedikaya; Fahriye Ulya Badıllı; A. Nurten Özdemir

Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers?

Abstract

Although curcumin is a commonly used antioxidant in cosmetic and pharmaceutical products, the dermal efficacy of curcumin is limited due to its very low solubility and poor permeability. Considering dermal application, lipid-based nanocarriers (LbNs) are highlighted as promising delivery systems for enhancing the efficacy of active substances. The aim of this study is to evaluate the effect of the components of LbNs on the antioxidant activity of curcumin. For this purpose, the mixture of Precirol® ATO5 and Tristearin was selected as solid lipid; while vitamin E, pomegranate seed oil (PSO) and Labrafac® Lipophile WL 1349 were used as liquid lipids. Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) formulations were designed by using different combination of these lipids and Gelucire®50/13 as an amphiphilic surfactant. The particle size, PDI, zeta potential analysis, encapsulation efficiency and in-vitro release studies were performed as particle characteristics. The contribution of LbNs with different structures to the antioxidant capacity of curcumin was evaluated by in-vitro ABTS scavenging experiment. While SLN has an average particle size of 106.7 nm with negative zeta potential, the size of NLC and NE formulations were below 100nm. The highest curcumin release upon 24h was obtained by NLC formulation prepared with PSO. A significant contribution to the antioxidant activity of curcumin was obtained when vitamin E and PSO were used as liquid lipid in NLC and NE formulations. In conclusion, it is possible to improve the antioxidant effect of curcumin by the modification of the structure of LbNs.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Gülin Amasya Çelikten
Türkiye

Ömer Yedikaya
Türkiye

Fahriye Ulya Badıllı ^*
Türkiye

A. Nurten Özdemir
Türkiye

Publication Date

June 27, 2025

Submission Date

August 12, 2022

Acceptance Date

October 18, 2022

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA29RM34MF

Cite

RIS / Bibtex

APA

Amasya Çelikten, G., Yedikaya, Ö., Badıllı, F. U., & Özdemir, A. N. (2025). Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers? Journal of Research in Pharmacy, 27(2), 566-576. https://izlik.org/JA29RM34MF

AMA

1.Amasya Çelikten G, Yedikaya Ö, Badıllı FU, Özdemir AN. Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers? J. Res. Pharm. 2025;27(2):566-576. https://izlik.org/JA29RM34MF

Chicago

Amasya Çelikten, Gülin, Ömer Yedikaya, Fahriye Ulya Badıllı, and A. Nurten Özdemir. 2025. “Is It Possible to Improve Antioxidant Activity of Curcumin With the Structure of Lipid- Based Nanocarriers?”. Journal of Research in Pharmacy 27 (2): 566-76. https://izlik.org/JA29RM34MF.

EndNote

Amasya Çelikten G, Yedikaya Ö, Badıllı FU, Özdemir AN (June 1, 2025) Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers? Journal of Research in Pharmacy 27 2 566–576.

IEEE

[1]G. Amasya Çelikten, Ö. Yedikaya, F. U. Badıllı, and A. N. Özdemir, “Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers?”, J. Res. Pharm., vol. 27, no. 2, pp. 566–576, June 2025, [Online]. Available: https://izlik.org/JA29RM34MF

ISNAD

Amasya Çelikten, Gülin - Yedikaya, Ömer - Badıllı, Fahriye Ulya - Özdemir, A. Nurten. “Is It Possible to Improve Antioxidant Activity of Curcumin With the Structure of Lipid- Based Nanocarriers?”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 566-576. https://izlik.org/JA29RM34MF.

JAMA

1.Amasya Çelikten G, Yedikaya Ö, Badıllı FU, Özdemir AN. Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers? J. Res. Pharm. 2025;27:566–576.

MLA

Amasya Çelikten, Gülin, et al. “Is It Possible to Improve Antioxidant Activity of Curcumin With the Structure of Lipid- Based Nanocarriers?”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 566-7, https://izlik.org/JA29RM34MF.

Vancouver

1.Gülin Amasya Çelikten, Ömer Yedikaya, Fahriye Ulya Badıllı, A. Nurten Özdemir. Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers? J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):566-7. Available from: https://izlik.org/JA29RM34MF