Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents

Year 2021, Volume: 25 Issue: 2, 135 - 141, 27.06.2025

Sevil Şenkardeş , Merve Eylül Kıymacı , Kübra Kale İsa Murat Kozanoğlu Banu Kaşkatepe Ş.güniz Küçükgüzel

https://doi.org/10.29228/jrp.4

Cited By: 2

https://izlik.org/JA35MB26YF

Abstract

In this study, some N′ ‑(substituted arylmethylidene)-4‑nitrobenzenesulfonohydrazide derivatives were synthesis by reacting various aldehydes and 4‑nitrobenzenesulfonohydrazide. The structural characterization of the compounds was performed by IR, 1H-NMR and TOF-MS (compounds 3b and 3e) spectroscopic data besides elementel analyses results. The antibacterial activities of these compounds were examined against some bacteria species. The compounds showed the highest activity against Pseudomonas aeruginosa ATCC 27853. Also, anti-quorum sensing activities have been determined using a biosensor bioassay with Chromobacterium violaceum CV026 and the signaling molecule N- hexanoyl-L-homoserine lactone. All the compounds were subjected for ADME predictions by computational method

Keywords

Sulfonyl hydrazone , hydrazide , MIC , antibacterial activity , quorum sensing

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