Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac

Sariye İrem Kaya; Göksu Özçelikay Akyıldız

Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac

Abstract

This study aimed to develop an electrochemical method for the electrochemical determination of bufexamac (BUF), an important anti-inflammatory drug. For this purpose, the electrochemical properties of BUF were elucidated using a glassy carbon electrode (GCE) and cyclic voltammetry. The electrochemical performance of BUF was examined by the differential pulse voltammetry (DPV) method. It was observed that the response of GCE to DBT was linear in the concentration range of 6.0 × 10–6 M and 1.0 × 10–4 M. The limit of detection (LOD) was found to be 2.64 × 10−8 M; The limit of quantification (LOQ) was calculated as 8.79 × 10−8 M. The dexketoprofen tromethamine (DEX), diclofenac (DIC), and ibuprofen (IBU) were used as model active compounds to illustrate the oxidation mechanism of BUF. A simple, rapid, and sensitive electrochemical method for quantitatively determining BUF in a commercial sample of human serum was developed and validated. The calibration curve was linear in the 8.0 × 10–6 – 1.0 × 10–4 M in the biological media. The LOD for the commercial sample of human serum was set at 1.59 × 10−7 M. The electrochemical response of BUF in the presence of interferent was evaluated. The data obtained from the study showed that the developed method can be used in sensitive and selective BUF determination.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Analytical Chemistry

Journal Section

Research Article

Authors

Sariye İrem Kaya ^*
0000-0003-0578-5399
Türkiye

Göksu Özçelikay Akyıldız
0000-0001-7919-3236
Türkiye

Publication Date

June 28, 2025

Submission Date

July 3, 2024

Acceptance Date

July 31, 2024

Published in Issue

Year 2024 Volume: 28 Number: 5

IZ

https://izlik.org/JA28FW69BZ

Cite

RIS / Bibtex

APA

Kaya, S. İ., & Özçelikay Akyıldız, G. (2025). Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. Journal of Research in Pharmacy, 28(5), 1562-1571. https://izlik.org/JA28FW69BZ

AMA

1.Kaya Sİ, Özçelikay Akyıldız G. Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. J. Res. Pharm. 2025;28(5):1562-1571. https://izlik.org/JA28FW69BZ

Chicago

Kaya, Sariye İrem, and Göksu Özçelikay Akyıldız. 2025. “Investigation of Electrochemical Behavior and Voltammetric Determination of the Anti-Inflammatory Agent Bufexamac”. Journal of Research in Pharmacy 28 (5): 1562-71. https://izlik.org/JA28FW69BZ.

EndNote

Kaya Sİ, Özçelikay Akyıldız G (July 1, 2025) Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. Journal of Research in Pharmacy 28 5 1562–1571.

IEEE

[1]S. İ. Kaya and G. Özçelikay Akyıldız, “Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac”, J. Res. Pharm., vol. 28, no. 5, pp. 1562–1571, July 2025, [Online]. Available: https://izlik.org/JA28FW69BZ

ISNAD

Kaya, Sariye İrem - Özçelikay Akyıldız, Göksu. “Investigation of Electrochemical Behavior and Voltammetric Determination of the Anti-Inflammatory Agent Bufexamac”. Journal of Research in Pharmacy 28/5 (July 1, 2025): 1562-1571. https://izlik.org/JA28FW69BZ.

JAMA

1.Kaya Sİ, Özçelikay Akyıldız G. Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. J. Res. Pharm. 2025;28:1562–1571.

MLA

Kaya, Sariye İrem, and Göksu Özçelikay Akyıldız. “Investigation of Electrochemical Behavior and Voltammetric Determination of the Anti-Inflammatory Agent Bufexamac”. Journal of Research in Pharmacy, vol. 28, no. 5, July 2025, pp. 1562-71, https://izlik.org/JA28FW69BZ.

Vancouver

1.Sariye İrem Kaya, Göksu Özçelikay Akyıldız. Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. J. Res. Pharm. [Internet]. 2025 Jul. 1;28(5):1562-71. Available from: https://izlik.org/JA28FW69BZ