Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant

İsmail Aslan; Leyla Tarhan Çelebi

Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant

Abstract

Antiperspirants are used many times a day to prevent bad odor in the armpit. Bad odor under the armpit is called organic volatile molecules. It is formed by the metabolism or breakdown of sweat secreted from sweat glands by microorganisms in the axillary region. Antiperspirants prevent sweat secretion by blocking the sweat glands thanks to the active ingredients in the antiperspirants and prevent the formation of bad odor by stopping the bacteria from metabolizing the secretions. These active substances are still used today as aluminum and its salts. Although the damage of aluminum salts on the skin is not fully known, their accumulation in the body causes toxicity. The search for new active substances to eliminate the negative health effects of the active substances used is still continuing today. The purpose of this research is to produce formulations containing active cosmetic ingredients with natural components that can be used in new formulations. Moreover, it includes the evaluation of the efficacy of active substances that will provide inhibition of bacteria that cause bad odor in the axillary microbiota by adding them to formulations. In studies conducted by adding Lactobacillius lysates (Acilac ATA-LTW12- Lactobacillus ferment lysate extract) obtained from probiotics combined with Humulus lupulus extract, Salvia officinalis leaf extract to the formulation, a decrease in microorganisms causing bad odor formation was observed. Microbiota differences between the formulation with and without postbiotics applied in an artificial axillary microbiota environment were observed. It was observed that the Lactobacıllus ferment lysate extract component used in the reduction of bad odor-causing microorganisms supported specific inhibition in the natural armpit microbiota and normalized the microbiota. There was no statistically significant difference between the negative control (PBS) and the antiperspirant without postbiotics. Significant statistical differences were observed between the antiperspirant containing postbiotic (Acilac ATA-LTW12- Lactobacillus ferment lysate extract) and the antiperspirant without postbiotic, and between the antiperspirant containing postbiotic and negative control. As a result, a new one has been added to the roll-on type antiperspirant formulation studies with natural ingredients free of aluminum salts, sustainable to nature, and presented to the literature for development.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

İsmail Aslan ^* This is me
Türkiye

Leyla Tarhan Çelebi
0009-0008-6861-1103
Türkiye

Publication Date

June 28, 2025

Submission Date

August 10, 2023

Acceptance Date

August 29, 2023

Published in Issue

Year 2023 Volume: 27 Number: 5

IZ

https://izlik.org/JA74UX66TS

Cite

RIS / Bibtex

APA

Aslan, İ., & Tarhan Çelebi, L. (2025). Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant. Journal of Research in Pharmacy, 27(5), 2095-2105. https://izlik.org/JA74UX66TS

AMA

1.Aslan İ, Tarhan Çelebi L. Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant. J. Res. Pharm. 2025;27(5):2095-2105. https://izlik.org/JA74UX66TS

Chicago

Aslan, İsmail, and Leyla Tarhan Çelebi. 2025. “Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant”. Journal of Research in Pharmacy 27 (5): 2095-2105. https://izlik.org/JA74UX66TS.

EndNote

Aslan İ, Tarhan Çelebi L (July 1, 2025) Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant. Journal of Research in Pharmacy 27 5 2095–2105.

IEEE

[1]İ. Aslan and L. Tarhan Çelebi, “Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant”, J. Res. Pharm., vol. 27, no. 5, pp. 2095–2105, July 2025, [Online]. Available: https://izlik.org/JA74UX66TS

ISNAD

Aslan, İsmail - Tarhan Çelebi, Leyla. “Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant”. Journal of Research in Pharmacy 27/5 (July 1, 2025): 2095-2105. https://izlik.org/JA74UX66TS.

JAMA

1.Aslan İ, Tarhan Çelebi L. Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant. J. Res. Pharm. 2025;27:2095–2105.

MLA

Aslan, İsmail, and Leyla Tarhan Çelebi. “Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant”. Journal of Research in Pharmacy, vol. 27, no. 5, July 2025, pp. 2095-0, https://izlik.org/JA74UX66TS.

Vancouver

1.İsmail Aslan, Leyla Tarhan Çelebi. Postbiotics Cosmetic Formulation: In Vitro Efficacy Studies on a Microbiome Friendly Antiperspirant. J. Res. Pharm. [Internet]. 2025 Jul. 1;27(5):2095-10. Available from: https://izlik.org/JA74UX66TS