Development and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study

Ayça Karasakal; Elif Özdemir

Development and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study

Abstract

Zero and first order derivative spectrophotometric methods were developed for the analysis of rilmenidine in pharmaceutical preparations. Absorbances of rilmenidine were measured at 224 nm for the zero order by measuring height of peak from zero and at 223.20 and 230.20 nm for the first order derivative spectrophotometric method by measuring peak to peak height. The linearity ranges were found to be 50-250 µg/mL for zero and first order spectrophotometric method. The developed methods were validated and the analytical parameters of linearity, limit of detection, limit of quantification, accuracy, precision and recovery were evaluated. In addition, Rilmenidine exposed to the stress conditions of acid, base and oxidative in order to calculate to degradation % by developed zero and first order derivative spectrophotometric method.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Analytical Chemistry

Journal Section

Research Article

Authors

Ayça Karasakal ^*
Türkiye

Elif Özdemir This is me
Türkiye

Publication Date

June 27, 2025

Submission Date

January 5, 2019

Acceptance Date

March 5, 2019

Published in Issue

Year 2019 Volume: 23 Number: 3

IZ

https://izlik.org/JA32EL65KS

Cite

RIS / Bibtex

APA

Karasakal, A., & Özdemir, E. (2025). Development and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study. Journal of Research in Pharmacy, 23(3), 457-464. https://izlik.org/JA32EL65KS

AMA

1.Karasakal A, Özdemir E. Development and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study. J. Res. Pharm. 2025;23(3):457-464. https://izlik.org/JA32EL65KS

Chicago

Karasakal, Ayça, and Elif Özdemir. 2025. “Development and Validation of First and Zero Order Derivative Spectrophotometric Methods for the Determination of Rilmenidine in Pharmaceutical Preparations and Forced Degradation Study”. Journal of Research in Pharmacy 23 (3): 457-64. https://izlik.org/JA32EL65KS.

EndNote

Karasakal A, Özdemir E (June 1, 2025) Development and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study. Journal of Research in Pharmacy 23 3 457–464.

IEEE

[1]A. Karasakal and E. Özdemir, “Development and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study”, J. Res. Pharm., vol. 23, no. 3, pp. 457–464, June 2025, [Online]. Available: https://izlik.org/JA32EL65KS

ISNAD

Karasakal, Ayça - Özdemir, Elif. “Development and Validation of First and Zero Order Derivative Spectrophotometric Methods for the Determination of Rilmenidine in Pharmaceutical Preparations and Forced Degradation Study”. Journal of Research in Pharmacy 23/3 (June 1, 2025): 457-464. https://izlik.org/JA32EL65KS.

JAMA

1.Karasakal A, Özdemir E. Development and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study. J. Res. Pharm. 2025;23:457–464.

MLA

Karasakal, Ayça, and Elif Özdemir. “Development and Validation of First and Zero Order Derivative Spectrophotometric Methods for the Determination of Rilmenidine in Pharmaceutical Preparations and Forced Degradation Study”. Journal of Research in Pharmacy, vol. 23, no. 3, June 2025, pp. 457-64, https://izlik.org/JA32EL65KS.

Vancouver

1.Ayça Karasakal, Elif Özdemir. Development and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study. J. Res. Pharm. [Internet]. 2025 Jun. 1;23(3):457-64. Available from: https://izlik.org/JA32EL65KS