Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone

Juste Baranauskaıte Ortasöz; Burcu Üner

Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone

Abstract

Enoxolone is a pentacyclic triterpenoid observed from Glycyrrhiza glabra and it has an antibacterial, antiviral and antifungal effects. However, enoxolone (ENX) has low oral bioavailability due to a first pass metabolism effect in the intestinal tract, poor intestinal permeability. The aim of this study was to develop the PVP based orodispersible films (ODFs) containing ENX by electrospinning and solvent casting methods and to compare in terms of their credibility for orodispersible delivery of ENX through a variety of in vitro and physical investigations. Physical properties such as thichness, weight variation, tensile strength, Young's modulus and elongation at break were investigated. Moreover, the in vitro release profile of ENX from prepared films were characterized in this study. The morphological structures of the prepared film formulations were examined under scanning electron microscope and the interaction between the ENX, film and PVP were determined by the FTIR spectroscopy.DSC analysis was performed to understand the thermal behavior of formulations and components. The results obtained proved that the electrospinning process can be used to produce ODF formulations with lower disintegration time (≈4.52 min), lower diameter (≈218.5 nm) and acceptable mechanical strength (≈370.55 MPa). The preliminary results as a proofof- concept demonstration reported here will shed a new light on the future design and application of ODFs by electrospinning method.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Juste Baranauskaıte Ortasöz ^*
0000-0002-0358-5759
Türkiye

Burcu Üner
0000-0003-4691-0432
Türkiye

Publication Date

June 28, 2025

Submission Date

February 28, 2022

Acceptance Date

May 24, 2022

Published in Issue

Year 2022 Volume: 26 Number: 5

IZ

https://izlik.org/JA59GP53YB

Cite

RIS / Bibtex

APA

Baranauskaıte Ortasöz, J., & Üner, B. (2025). Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone. Journal of Research in Pharmacy, 26(5), 1242-1251. https://izlik.org/JA59GP53YB

AMA

1.Baranauskaıte Ortasöz J, Üner B. Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone. J. Res. Pharm. 2025;26(5):1242-1251. https://izlik.org/JA59GP53YB

Chicago

Baranauskaıte Ortasöz, Juste, and Burcu Üner. 2025. “Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone”. Journal of Research in Pharmacy 26 (5): 1242-51. https://izlik.org/JA59GP53YB.

EndNote

Baranauskaıte Ortasöz J, Üner B (June 1, 2025) Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone. Journal of Research in Pharmacy 26 5 1242–1251.

IEEE

[1]J. Baranauskaıte Ortasöz and B. Üner, “Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone”, J. Res. Pharm., vol. 26, no. 5, pp. 1242–1251, June 2025, [Online]. Available: https://izlik.org/JA59GP53YB

ISNAD

Baranauskaıte Ortasöz, Juste - Üner, Burcu. “Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone”. Journal of Research in Pharmacy 26/5 (June 1, 2025): 1242-1251. https://izlik.org/JA59GP53YB.

JAMA

1.Baranauskaıte Ortasöz J, Üner B. Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone. J. Res. Pharm. 2025;26:1242–1251.

MLA

Baranauskaıte Ortasöz, Juste, and Burcu Üner. “Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone”. Journal of Research in Pharmacy, vol. 26, no. 5, June 2025, pp. 1242-51, https://izlik.org/JA59GP53YB.

Vancouver

1.Juste Baranauskaıte Ortasöz, Burcu Üner. Preparation and Characterization Studies of Nanofiber and Orodispersable Film Formulations of Enoxolone. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(5):1242-51. Available from: https://izlik.org/JA59GP53YB