Research Article

Formulation and evaluation of intimate wash containing manuka oil and salix bark extract

Volume: 26 Number: 5 June 28, 2025

Formulation and evaluation of intimate wash containing manuka oil and salix bark extract

Abstract

Most of the feminine hygiene products sold in the market contain heavy chemicals that damage the mucosa. The well-designed intim formulation cleans without damage, supports the flora, protects against dryness, and maintenances of balanced microflora. For this purpose, we designed formulations made with natural raw materials such as manuka oil and Salix alba bark extract and investigated their irritation potential and effectiveness. A healthy vagina is dominated by Lactobacillus that produces lactic acid, resulting in a characteristic acidic environment (pH 3– 4), as it correlates with vaginal health by inhibiting the growth of bacteria and may also play a part in local immune defense. This new manuka oil- salix bark extract containing wash formulation was specifically formulated to achieve a formulation pH of 4.6-4.8 to be compatible with the normal skin pH range and to help maintain vulvovaginal skin homeostasis and provide protection against harmful bacteria. The formulation we designed was used by volunteers for 4 weeks and was found suitable in terms of gentle clean, refreshing feeling, shooting the skin, smell and irritation properties. None of the volunteers have experienced any side effects during product application. Our study findings further support other studies that have found that women who use intim wash attitudes and perceptions about hygiene.

Keywords

References

  1. [1] Chen Y, Bruning E, Rubino J, Eder SE. Role of female intimate hygiene in vulvovaginal health: Global hygiene practices and product usage. Womens Health. 2017; 13 (3):58-67. [CrossRef]
  2. [2] Arab H, Almadani L, Tahlak M, Chawla M, Ashouri M, Tehranian A, Ghasemi A, Taheripanah, Gulyaf M, Khalil A, Haddad E. The Middle East and Central Asia guidelines on female genital hygiene. BMJ Middle East 2011. 19: 99– 106.
  3. [3] Farage MA, Maibach HI. Tissue structure and physiology of the vulva. In: Farage MA, Maibach HI. (eds) The vulva: anatomy, physiology and pathology. New York: Informa Healthcare, 2016, pp. 9–26.
  4. [4] Britz MB, Maibach HI. Human cutaneous vulvar reactivity to irritants. Contact Dermatitis 1979; 5(6): 375–377. [CrossRef]
  5. [5] Elsner P, Wilhelm D, Maibach HI. Effect of low-concentration sodium lauryl sulfate on human vulvar and forearm skin. Age-related differences. J Reprod Med. 1991; 36(1): 77–81.
  6. [6] Elsner P, Wilhelm D, Maibach HI. Sodium lauryl sulfate-induced irritant contact dermatitis in vulvar and forearm skin of premenopausal and postmenopausal women. J Am Acad Dermatol. 1990; 23(4 Pt 1): 648–652. [CrossRef]
  7. [7] Farage MA. Vulvar susceptibility to contact irritants and allergens: a review. Arch Gynecol Obstet. 2005; 272(2): 167– 172. [CrossRef]
  8. [8] Wakashin K. Sanitary napkin contact dermatitis of the vulva: location-dependent differences in skin surface conditions may play a role in negative patch test results. J Dermatol. 2007; 34(12): 834–837. [CrossRef]

Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Publication Date

June 28, 2025

Submission Date

June 29, 2022

Acceptance Date

July 22, 2022

Published in Issue

Year 2022 Volume: 26 Number: 5

APA
Gedik, G. (2025). Formulation and evaluation of intimate wash containing manuka oil and salix bark extract. Journal of Research in Pharmacy, 26(5), 1252-1260. https://izlik.org/JA54AT29TM
AMA
1.Gedik G. Formulation and evaluation of intimate wash containing manuka oil and salix bark extract. J. Res. Pharm. 2025;26(5):1252-1260. https://izlik.org/JA54AT29TM
Chicago
Gedik, Gülşah. 2025. “Formulation and Evaluation of Intimate Wash Containing Manuka Oil and Salix Bark Extract”. Journal of Research in Pharmacy 26 (5): 1252-60. https://izlik.org/JA54AT29TM.
EndNote
Gedik G (June 1, 2025) Formulation and evaluation of intimate wash containing manuka oil and salix bark extract. Journal of Research in Pharmacy 26 5 1252–1260.
IEEE
[1]G. Gedik, “Formulation and evaluation of intimate wash containing manuka oil and salix bark extract”, J. Res. Pharm., vol. 26, no. 5, pp. 1252–1260, June 2025, [Online]. Available: https://izlik.org/JA54AT29TM
ISNAD
Gedik, Gülşah. “Formulation and Evaluation of Intimate Wash Containing Manuka Oil and Salix Bark Extract”. Journal of Research in Pharmacy 26/5 (June 1, 2025): 1252-1260. https://izlik.org/JA54AT29TM.
JAMA
1.Gedik G. Formulation and evaluation of intimate wash containing manuka oil and salix bark extract. J. Res. Pharm. 2025;26:1252–1260.
MLA
Gedik, Gülşah. “Formulation and Evaluation of Intimate Wash Containing Manuka Oil and Salix Bark Extract”. Journal of Research in Pharmacy, vol. 26, no. 5, June 2025, pp. 1252-60, https://izlik.org/JA54AT29TM.
Vancouver
1.Gülşah Gedik. Formulation and evaluation of intimate wash containing manuka oil and salix bark extract. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(5):1252-60. Available from: https://izlik.org/JA54AT29TM