Research Article

Antiestrogenic and toxicological evaluation of methanolic extract of Saraca asoca and Cynometra travancorica

Volume: 26 Number: 5 June 28, 2025
Journal of Research in Pharmacy Cover
Journal of Research in Pharmacy
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Antiestrogenic and toxicological evaluation of methanolic extract of Saraca asoca and Cynometra travancorica

Abstract

Saraca asoca, a member of the Caesalpinaceae sub-family, is a native plant utilized extensively in ayurvedic medicine. Excessive menstrual bleeding, bleeding hemorrhoids, bleeding ulcers, and hemorrhagic dysentery can all be treated with the tannins found in the bark of S. asoca. Due to the scarcity of S. asoca, the ayurvedic formulation business was forced to use barks of comparable origin. Until recently, the pharmacological potential of frequently substituted Cynometra travancorica was unknown. The purpose of this research is to investigate and evaluate the antiestrogenic and toxicological effects of two Caesalpiniaceae members, S. asoca and C. travancorica, on Wistar female rats. Methanolic bark extract of both plants (600 mg/kg) was shown to be significantly effective in reducing the elevated estrogen (20 μg/animal) levels in Wistar female rats. The C. travancorica treated group showed an 85.63 ± 11.38 pg/ml reduction. In the toxicological evaluation, even at high concentrations of 800 mg/kg, neither of the extracts was fatal to Swiss albino mice. Food and water consumption, body weight, and the weight of organs such as the liver, kidney, spleen, heart, and lungs did not change significantly. The hematological parameters also stagnated. The study concluded that C. travancorica had shown a substantial and comparable anti-estrogenic effect to S. asoca in Wistar female rats and, similarly, the toxicological evaluation of the former plant was analogous to the latter. As a result, C. travancorica has a comparable therapeutic and safety profile in a wide range of ayurvedic formulations.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Krishnapriya Anil This is me
0000-0002-2683-2310
India

Publication Date

June 28, 2025

Submission Date

November 6, 2021

Acceptance Date

April 2, 2022

Published in Issue

Year 2022 Volume: 26 Number: 5

IZ

https://izlik.org/JA52ZM94GW

Cite

RIS / Bibtex
APA
Suhail, P., Joseph, S., V, A., Ss, S., & Anil, K. (2025). Antiestrogenic and toxicological evaluation of methanolic extract of Saraca asoca and Cynometra travancorica. Journal of Research in Pharmacy, 26(5), 1261-1271. https://izlik.org/JA52ZM94GW
AMA
1.Suhail P, Joseph S, V A, Ss S, Anil K. Antiestrogenic and toxicological evaluation of methanolic extract of Saraca asoca and Cynometra travancorica. J. Res. Pharm. 2025;26(5):1261-1271. https://izlik.org/JA52ZM94GW
Chicago
Suhail, Pattilthodika, Sheron Joseph, Ajeesh V, Sreelakshmi Ss, and Krishnapriya Anil. 2025. “Antiestrogenic and Toxicological Evaluation of Methanolic Extract of Saraca Asoca and Cynometra Travancorica”. Journal of Research in Pharmacy 26 (5): 1261-71. https://izlik.org/JA52ZM94GW.
EndNote
Suhail P, Joseph S, V A, Ss S, Anil K (June 1, 2025) Antiestrogenic and toxicological evaluation of methanolic extract of Saraca asoca and Cynometra travancorica. Journal of Research in Pharmacy 26 5 1261–1271.
IEEE
[1]P. Suhail, S. Joseph, A. V, S. Ss, and K. Anil, “Antiestrogenic and toxicological evaluation of methanolic extract of Saraca asoca and Cynometra travancorica”, J. Res. Pharm., vol. 26, no. 5, pp. 1261–1271, June 2025, [Online]. Available: https://izlik.org/JA52ZM94GW
ISNAD
Suhail, Pattilthodika - Joseph, Sheron - V, Ajeesh - Ss, Sreelakshmi - Anil, Krishnapriya. “Antiestrogenic and Toxicological Evaluation of Methanolic Extract of Saraca Asoca and Cynometra Travancorica”. Journal of Research in Pharmacy 26/5 (June 1, 2025): 1261-1271. https://izlik.org/JA52ZM94GW.
JAMA
1.Suhail P, Joseph S, V A, Ss S, Anil K. Antiestrogenic and toxicological evaluation of methanolic extract of Saraca asoca and Cynometra travancorica. J. Res. Pharm. 2025;26:1261–1271.
MLA
Suhail, Pattilthodika, et al. “Antiestrogenic and Toxicological Evaluation of Methanolic Extract of Saraca Asoca and Cynometra Travancorica”. Journal of Research in Pharmacy, vol. 26, no. 5, June 2025, pp. 1261-7, https://izlik.org/JA52ZM94GW.
Vancouver
1.Pattilthodika Suhail, Sheron Joseph, Ajeesh V, Sreelakshmi Ss, Krishnapriya Anil. Antiestrogenic and toxicological evaluation of methanolic extract of Saraca asoca and Cynometra travancorica. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(5):1261-7. Available from: https://izlik.org/JA52ZM94GW