Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats

Ayfer Beceren; Sezgin Aydemir; Beste Melek Atasoy; Esin Ak; Feriha Ercan; Tarık Emre Şener; Göksel Şener

Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats

Abstract

Radiotherapy, which is routinely used to treat a wide range of oncological disorders, primarily affects the malignant tissue in the targeted area, but also have negative effects in the surrounding tissues. Pelvic radiotherapy causes early and late effects on the colon and rectum. Resveratrol (RVT) has been revealed to have a number of pharmacological effects in a variety of experimental models and clinical circumstances, therefore it has piqued the interest of scientists in recent years. In this study, we aimed to investigate the potential protective effects of resveratrol (RVT), a strong antioxidant, anti-inflammatory and anti-mutagenic agent, against toxicity of colonic and rectal tissues seen in the early and late stages after pelvic radiation. The treatment durations of the current study were designed as one week and ten weeks interval by following radiation exposure. Sprague Dawley rats were divided into 5 groups (8 animals/group) as the control, radiation-early effects (Rd-E), radiation-late effects (Rd-L), and RVT-treated Rd-E (Rd-E+RVT) and RVT-treated Rd-L (Rd-L+RVT) groups. İonizing radiation was performed to the pelvic area that covers colon and rectum in single fraction of 20 Gy in a linear accelerator using with 6 MV photon energy. RVT was orally administered (10 mg/kg/day) immediately following the radiation exposure and continued daily for 1 and 10 weeks for early and late groups, respectively. Pelvic radiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and 8-hydroxydeoxyguanosine were increased in both Rd-E and Rd-L groups in the colon and rectum tissues. Additionally, light microscopic evaluations (H&E staining) revealed degeneration of epithelium and inflammatory cell infiltration in the colonic and rectal tissues in radiation groups. RVT treatment reversed all conducted biochemical parameters and ameliorated histomorphological changes following early and late effects of pelvic radiation in tissues. In conclusion, resveratrol may be a candidate as a radioprotector for normal tissues during and after radiotherapy.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Toxicology

Journal Section

Research Article

Authors

Ayfer Beceren ^*
0000-0002-6770-6089
Türkiye

Sezgin Aydemir
Türkiye

Beste Melek Atasoy This is me
Türkiye

Esin Ak
0000-0002-3467-7808
Türkiye

Feriha Ercan
0000-0003-2339-5669
Türkiye

Tarık Emre Şener This is me
0000-0003-0085-7680
Türkiye

Göksel Şener
Türkiye

Publication Date

June 28, 2025

Submission Date

June 16, 2023

Acceptance Date

July 7, 2023

Published in Issue

Year 2023 Volume: 27 Number: 4

IZ

https://izlik.org/JA48LU79UJ

Cite

RIS / Bibtex

APA

Beceren, A., Aydemir, S., Atasoy, B. M., Ak, E., Ercan, F., Şener, T. E., & Şener, G. (2025). Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats. Journal of Research in Pharmacy, 27(4), 1617-1625. https://izlik.org/JA48LU79UJ

AMA

1.Beceren A, Aydemir S, Atasoy BM, et al. Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats. J. Res. Pharm. 2025;27(4):1617-1625. https://izlik.org/JA48LU79UJ

Chicago

Beceren, Ayfer, Sezgin Aydemir, Beste Melek Atasoy, et al. 2025. “Radioprotective Effect of Resveratrol for Early and Late Ionizing Radiation-Induced Damages on Colon and Rectum in Rats”. Journal of Research in Pharmacy 27 (4): 1617-25. https://izlik.org/JA48LU79UJ.

EndNote

Beceren A, Aydemir S, Atasoy BM, Ak E, Ercan F, Şener TE, Şener G (July 1, 2025) Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats. Journal of Research in Pharmacy 27 4 1617–1625.

IEEE

[1]A. Beceren et al., “Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats”, J. Res. Pharm., vol. 27, no. 4, pp. 1617–1625, July 2025, [Online]. Available: https://izlik.org/JA48LU79UJ

ISNAD

Beceren, Ayfer - Aydemir, Sezgin - Atasoy, Beste Melek - Ak, Esin - Ercan, Feriha - Şener, Tarık Emre - Şener, Göksel. “Radioprotective Effect of Resveratrol for Early and Late Ionizing Radiation-Induced Damages on Colon and Rectum in Rats”. Journal of Research in Pharmacy 27/4 (July 1, 2025): 1617-1625. https://izlik.org/JA48LU79UJ.

JAMA

1.Beceren A, Aydemir S, Atasoy BM, Ak E, Ercan F, Şener TE, Şener G. Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats. J. Res. Pharm. 2025;27:1617–1625.

MLA

Beceren, Ayfer, et al. “Radioprotective Effect of Resveratrol for Early and Late Ionizing Radiation-Induced Damages on Colon and Rectum in Rats”. Journal of Research in Pharmacy, vol. 27, no. 4, July 2025, pp. 1617-25, https://izlik.org/JA48LU79UJ.

Vancouver

1.Ayfer Beceren, Sezgin Aydemir, Beste Melek Atasoy, Esin Ak, Feriha Ercan, Tarık Emre Şener, Göksel Şener. Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats. J. Res. Pharm. [Internet]. 2025 Jul. 1;27(4):1617-25. Available from: https://izlik.org/JA48LU79UJ