Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue

Zarife Nigar Özdemir Kumral; Nurdan Bülbül Aycı; Özlem Tuğçe Çilingir Kaya; Hızır Kurtel

Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue

Abstract

The aim of the study is to explain the possible effects of exercise-induced novel peptide irisin on endothelial function accompanied by perivascular adipose tissue (PVAT) in aortas of both natural aging and D- galactose (D-Gal) aging mimetic rats. Female Sprague-Dawley rats were randomly divided into 6 groups (n=10/per group): sedentary young group (SY), exercised young group (EY), sedentary aging group (SA), exercised aging group (EA), sedentary D-Gal (300 mg/kg/day, i.p., 9 weeks) induced aging group (S+D-Gal), exercised D-Gal induced aging group (E+D-Gal). Cardiac and aortic samples were collected for biochemical and histopathological examinations. The aortas were taken for contractile response studies in the absence or presence of perivascular adipose tissue (PVAT-/+). The levels of irisin in both plasma and PVAT were detected. Regardless of the models the vaso-relaxant effects of irisin were shown alone and age-related vascular dysfunction has also been recorded compared to the SY group these age- related impaired irisin responses were found to be improved by regular exercise. The plasma and PVAT irisin levels were decreased by aging and exercise reversed this decrement which is verified by the immune expression of irisin in aortic and PVAT tissues. Our results show the differences in vascular function and PVAT in aging and the contribution of PVAT to the response of irisin with exercise in two different aging models.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Zarife Nigar Özdemir Kumral ^*
0000-0002-9485-0174
Türkiye

Nurdan Bülbül Aycı
0000-0001-5270-1130
Türkiye

Özlem Tuğçe Çilingir Kaya
0000-0002-2591-9174
Türkiye

Hızır Kurtel
0000-0003-3633-7863
Türkiye

Publication Date

June 27, 2025

Submission Date

January 24, 2023

Acceptance Date

March 1, 2023

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA99HJ59ZY

Cite

RIS / Bibtex

APA

Özdemir Kumral, Z. N., Bülbül Aycı, N., Çilingir Kaya, Ö. T., & Kurtel, H. (2025). Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. Journal of Research in Pharmacy, 27(2), 733-752. https://izlik.org/JA99HJ59ZY

AMA

1.Özdemir Kumral ZN, Bülbül Aycı N, Çilingir Kaya ÖT, Kurtel H. Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. J. Res. Pharm. 2025;27(2):733-752. https://izlik.org/JA99HJ59ZY

Chicago

Özdemir Kumral, Zarife Nigar, Nurdan Bülbül Aycı, Özlem Tuğçe Çilingir Kaya, and Hızır Kurtel. 2025. “Impaired Vascular Function Induced by Aging: Role of Irisin and Perivascular Adipose Tissue”. Journal of Research in Pharmacy 27 (2): 733-52. https://izlik.org/JA99HJ59ZY.

EndNote

Özdemir Kumral ZN, Bülbül Aycı N, Çilingir Kaya ÖT, Kurtel H (June 1, 2025) Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. Journal of Research in Pharmacy 27 2 733–752.

IEEE

[1]Z. N. Özdemir Kumral, N. Bülbül Aycı, Ö. T. Çilingir Kaya, and H. Kurtel, “Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue”, J. Res. Pharm., vol. 27, no. 2, pp. 733–752, June 2025, [Online]. Available: https://izlik.org/JA99HJ59ZY

ISNAD

Özdemir Kumral, Zarife Nigar - Bülbül Aycı, Nurdan - Çilingir Kaya, Özlem Tuğçe - Kurtel, Hızır. “Impaired Vascular Function Induced by Aging: Role of Irisin and Perivascular Adipose Tissue”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 733-752. https://izlik.org/JA99HJ59ZY.

JAMA

1.Özdemir Kumral ZN, Bülbül Aycı N, Çilingir Kaya ÖT, Kurtel H. Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. J. Res. Pharm. 2025;27:733–752.

MLA

Özdemir Kumral, Zarife Nigar, et al. “Impaired Vascular Function Induced by Aging: Role of Irisin and Perivascular Adipose Tissue”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 733-52, https://izlik.org/JA99HJ59ZY.

Vancouver

1.Zarife Nigar Özdemir Kumral, Nurdan Bülbül Aycı, Özlem Tuğçe Çilingir Kaya, Hızır Kurtel. Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):733-52. Available from: https://izlik.org/JA99HJ59ZY