The possible mechanisms of high-fructose diet-induced pancreatic disturbances

Ceren Güney; Fatma Akar

The possible mechanisms of high-fructose diet-induced pancreatic disturbances

Abstract

Excess fructose consumption in the regular human diet causes several health problems. The main source of dietary fructose is sugar-sweetened beverages, which are especially consumed by children and teenagers. High- fructose intake is one of the major responsible factors of the increased prevalence of metabolic syndrome and type 2 diabetes worldwide. The dietary high-fructose-induced metabolic syndrome was evidenced by hyperglycemia, hyperinsulinemia, hyperlipidemia, hypertension, fatty liver disease, central adiposity, and inflammation. Molecular findings indicated that there was a suppression of insulin signaling and activation of oxidative stress in different tissues including the liver, blood vessels, adipose tissue, and kidney in the excess intake of fructose. However, there is a limited mechanistic study on the pancreatic disturbances induced by dietary high-fructose. The hyperglycemic condition in the consumption of high-fructose may lead to morphologic and pathological changes to increase the capacity of insulin secretion in the pancreas. High-fructose can activate the mitogenic and apoptotic pathways, thus probably inducing hyperplasia in β-cells. The overactivation of β-cells can trigger oxidative and endoplasmic reticulum stress as well as inflammation in the pancreas. In conclusion, high-fructose consumption may cause pancreatic disturbance possibly through stimulation of cellular oxidative stress, inflammation, mitogenesis, and apoptosis. Pancreas is one of the first organs affected by metabolic abnormalities, therefore, elucidation of potential mechanisms underlying high-fructose diet-induced pancreatic pathologies would be valuable in the prevention and treatment of the metabolic syndrome as well as type 2 diabetes.

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Review

Authors

Ceren Güney
0000-0002-3267-2886
Türkiye

Fatma Akar ^*
0000-0002-5432-0304
Türkiye

Publication Date

June 27, 2025

Submission Date

January 14, 2023

Acceptance Date

March 1, 2023

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA49JF76FS

Cite

RIS / Bibtex

APA

Güney, C., & Akar, F. (2025). The possible mechanisms of high-fructose diet-induced pancreatic disturbances. Journal of Research in Pharmacy, 27(2), 753-761. https://izlik.org/JA49JF76FS

AMA

1.Güney C, Akar F. The possible mechanisms of high-fructose diet-induced pancreatic disturbances. J. Res. Pharm. 2025;27(2):753-761. https://izlik.org/JA49JF76FS

Chicago

Güney, Ceren, and Fatma Akar. 2025. “The Possible Mechanisms of High-Fructose Diet-Induced Pancreatic Disturbances”. Journal of Research in Pharmacy 27 (2): 753-61. https://izlik.org/JA49JF76FS.

EndNote

Güney C, Akar F (June 1, 2025) The possible mechanisms of high-fructose diet-induced pancreatic disturbances. Journal of Research in Pharmacy 27 2 753–761.

IEEE

[1]C. Güney and F. Akar, “The possible mechanisms of high-fructose diet-induced pancreatic disturbances”, J. Res. Pharm., vol. 27, no. 2, pp. 753–761, June 2025, [Online]. Available: https://izlik.org/JA49JF76FS

ISNAD

Güney, Ceren - Akar, Fatma. “The Possible Mechanisms of High-Fructose Diet-Induced Pancreatic Disturbances”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 753-761. https://izlik.org/JA49JF76FS.

JAMA

1.Güney C, Akar F. The possible mechanisms of high-fructose diet-induced pancreatic disturbances. J. Res. Pharm. 2025;27:753–761.

MLA

Güney, Ceren, and Fatma Akar. “The Possible Mechanisms of High-Fructose Diet-Induced Pancreatic Disturbances”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 753-61, https://izlik.org/JA49JF76FS.

Vancouver

1.Ceren Güney, Fatma Akar. The possible mechanisms of high-fructose diet-induced pancreatic disturbances. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):753-61. Available from: https://izlik.org/JA49JF76FS