Brain in metabolic syndrome model: The effect of exercises and caloric restriction

Burcin Alev; Nevin Genç Kahraman; Hazal İpekçi; Ünsal Veli Üstündağ; Tuğba Tunalı-akbay; Ebru Emekli Alturfan; Göksel Şener; Aysen Yarat

Brain in metabolic syndrome model: The effect of exercises and caloric restriction

Abstract

Caloric restriction (CR) and exercise (EX) have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX and/or CR in metabolic syndrome (MeS) induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10% fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX and/or CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control (C) group. These parameters reduced significantly in the metabolic syndrome with caloric restriction (MeS+CR) group, and more significantly in the metabolic syndrome with exercise and caloric restriction group (MeS+EXCR), compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeS+CR group, and MeS+EXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeS+EXCR group.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Sciences

Journal Section

Research Article

Authors

Burcin Alev ^*
0000-0001-5122-4977
Türkiye

Nevin Genç Kahraman
0000-0003-2143-0088
Türkiye

Hazal İpekçi
0000-0003-1193-168X
Türkiye

Ünsal Veli Üstündağ
0000-0003-0804-1475
Türkiye

Tuğba Tunalı-akbay
0000-0002-2091-9298
Türkiye

Ebru Emekli Alturfan
Türkiye

Göksel Şener
0000-0001-7444-6193
Türkiye

Aysen Yarat
0000-0002-8258-6118
Türkiye

Publication Date

June 28, 2025

Submission Date

April 1, 2022

Acceptance Date

May 23, 2022

Published in Issue

Year 2022 Volume: 26 Number: 5

IZ

https://izlik.org/JA22RN69XE

Cite

RIS / Bibtex

APA

Alev, B., Genç Kahraman, N., İpekçi, H., Üstündağ, Ü. V., Tunalı-akbay, T., Emekli Alturfan, E., Şener, G., & Yarat, A. (2025). Brain in metabolic syndrome model: The effect of exercises and caloric restriction. Journal of Research in Pharmacy, 26(5), 1352-1362. https://izlik.org/JA22RN69XE

AMA

1.Alev B, Genç Kahraman N, İpekçi H, et al. Brain in metabolic syndrome model: The effect of exercises and caloric restriction. J. Res. Pharm. 2025;26(5):1352-1362. https://izlik.org/JA22RN69XE

Chicago

Alev, Burcin, Nevin Genç Kahraman, Hazal İpekçi, et al. 2025. “Brain in Metabolic Syndrome Model: The Effect of Exercises and Caloric Restriction”. Journal of Research in Pharmacy 26 (5): 1352-62. https://izlik.org/JA22RN69XE.

EndNote

Alev B, Genç Kahraman N, İpekçi H, Üstündağ ÜV, Tunalı-akbay T, Emekli Alturfan E, Şener G, Yarat A (June 1, 2025) Brain in metabolic syndrome model: The effect of exercises and caloric restriction. Journal of Research in Pharmacy 26 5 1352–1362.

IEEE

[1]B. Alev et al., “Brain in metabolic syndrome model: The effect of exercises and caloric restriction”, J. Res. Pharm., vol. 26, no. 5, pp. 1352–1362, June 2025, [Online]. Available: https://izlik.org/JA22RN69XE

ISNAD

Alev, Burcin - Genç Kahraman, Nevin - İpekçi, Hazal - Üstündağ, Ünsal Veli - Tunalı-akbay, Tuğba - Emekli Alturfan, Ebru - Şener, Göksel - Yarat, Aysen. “Brain in Metabolic Syndrome Model: The Effect of Exercises and Caloric Restriction”. Journal of Research in Pharmacy 26/5 (June 1, 2025): 1352-1362. https://izlik.org/JA22RN69XE.

JAMA

1.Alev B, Genç Kahraman N, İpekçi H, Üstündağ ÜV, Tunalı-akbay T, Emekli Alturfan E, Şener G, Yarat A. Brain in metabolic syndrome model: The effect of exercises and caloric restriction. J. Res. Pharm. 2025;26:1352–1362.

MLA

Alev, Burcin, et al. “Brain in Metabolic Syndrome Model: The Effect of Exercises and Caloric Restriction”. Journal of Research in Pharmacy, vol. 26, no. 5, June 2025, pp. 1352-6, https://izlik.org/JA22RN69XE.

Vancouver

1.Burcin Alev, Nevin Genç Kahraman, Hazal İpekçi, Ünsal Veli Üstündağ, Tuğba Tunalı-akbay, Ebru Emekli Alturfan, Göksel Şener, Aysen Yarat. Brain in metabolic syndrome model: The effect of exercises and caloric restriction. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(5):1352-6. Available from: https://izlik.org/JA22RN69XE