Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease

Merve İrem Özen; Oya Kerimoğlu

Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease

Abstract

Nowadays, innovative and more effective drug dosage forms continue to be researched and developed compared to traditional drug dosage forms. The importance of orally disintegrating films (ODFs) in current studies and advancements cannot be overstated. This study aims to create the optimum ODF formulations using pullulan and lycoat with donepezil hydrochloride (donepezil HCl). Plasticizers such as polyethylene glycol 400 (PEG-400) and glycerine were used to form flexible films. In the characterization studies of the films produced by the solvent casting technique: determination of morphology, determination of folding, determination of disintegration time, determination of thickness, determination of swelling, determination of pH, determination of mass uniformity, determination of In vitro release, and determination of content uniformity studies were carried out. According to the results obtained, the non- brittle, smooth-surfaced films were disintegrated in the mouth in an average of 35 seconds. Since the 10th minute, more than 85% of the active pharmaceutical ingredient (API) has been revealed. These values suggested that the pullulan polymer showed better film-forming capacity when used with lycoat polymer. Ultraviolet (UV)-visible spectrum studies were carried out to validate donepezil HCl. Thanks to the ODFs containing donepezil HCl, an effective and safe, innovative clinical use has been achieved in the treatment of diseases such as dementia and Alzheimer, which are characterized by a decrease in daily life activities and atrophy in cognitive abilities.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biotechnology

Journal Section

Research Article

Authors

Merve İrem Özen ^* This is me
0000-0003-4497-9022
Türkiye

Oya Kerimoğlu
0000-0003-2619-0490
Türkiye

Publication Date

June 27, 2025

Submission Date

November 15, 2022

Acceptance Date

December 14, 2022

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA74LF67SN

Cite

RIS / Bibtex

APA

Özen, M. İ., & Kerimoğlu, O. (2025). Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. Journal of Research in Pharmacy, 27(2), 893-902. https://izlik.org/JA74LF67SN

AMA

1.Özen Mİ, Kerimoğlu O. Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. J. Res. Pharm. 2025;27(2):893-902. https://izlik.org/JA74LF67SN

Chicago

Özen, Merve İrem, and Oya Kerimoğlu. 2025. “Evaluation and Characterization of Orally Disintegrating Films Loaded Donepezil Hydrochloride for Alzheimer’s Disease”. Journal of Research in Pharmacy 27 (2): 893-902. https://izlik.org/JA74LF67SN.

EndNote

Özen Mİ, Kerimoğlu O (June 1, 2025) Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. Journal of Research in Pharmacy 27 2 893–902.

IEEE

[1]M. İ. Özen and O. Kerimoğlu, “Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease”, J. Res. Pharm., vol. 27, no. 2, pp. 893–902, June 2025, [Online]. Available: https://izlik.org/JA74LF67SN

ISNAD

Özen, Merve İrem - Kerimoğlu, Oya. “Evaluation and Characterization of Orally Disintegrating Films Loaded Donepezil Hydrochloride for Alzheimer’s Disease”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 893-902. https://izlik.org/JA74LF67SN.

JAMA

1.Özen Mİ, Kerimoğlu O. Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. J. Res. Pharm. 2025;27:893–902.

MLA

Özen, Merve İrem, and Oya Kerimoğlu. “Evaluation and Characterization of Orally Disintegrating Films Loaded Donepezil Hydrochloride for Alzheimer’s Disease”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 893-02, https://izlik.org/JA74LF67SN.

Vancouver

1.Merve İrem Özen, Oya Kerimoğlu. Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):893-902. Available from: https://izlik.org/JA74LF67SN