Clinical assessment of an ointment obtained from Alkanna orientalis root extract in the management of burn wounds: a pilot cross-sectional clinical trial

Farnoush Seyyedi; Kavous Shahsavarinia; Babak Davami; Hossein Nazemiyeh; Aliasghar Kheiri; Hadi Valizadeh; Laleh Khodaie; Afshin Gharekhani

Clinical assessment of an ointment obtained from Alkanna orientalis root extract in the management of burn wounds: a pilot cross-sectional clinical trial

Abstract

Alkanna orientalis is known as a wound healing herb in Persian medicine. This study aimed to evaluate the effect of the ointment prepared from the extract of A. orientalis roots on the treatment of grade 1 and 2 burn injuries. Methods: This study was performed over one year in Sina hospital of Tabriz University of Medical Sciences. Patients, based on inclusion criteria, were divided into two categories of control and intervention groups. The control group received the current protocol of burn care of Sina hospital, while the case group received the routine treatment protocol alongside the herbal formulation for burn injury. The parameters indicating the efficacy of the herbal ointment were studied in both groups. Results: this study was performed on 60 patients (30 males and 30 females). The results showed that the patients who received herbal ointment formulation experienced a shorter duration of treatment and better therapeutic response. Also, the application of herbal formulation prevented the progression of wounds to higher grades. The duration of epithelial layer formation at the wound bed in control and intervention groups was 6.5±0.2 and 3.4±0.3 days (P-value<0.05), respectively. Successively, the rate of complete recovery of wound in control and intervention groups was 46.7% and 73.3% (P-value<0.05). The herbal ointment accelerated the recovery by 3.1±0.1 days (P-value<0.05). Conclusion: the results of this pilot study illustrated the efficacy of the prepared formulation on burn injuries which could be used alongside the conventional treatment protocol of burn care.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Clinical Research

Authors

Farnoush Seyyedi This is me
0009-0000-5576-3193
Iran

Kavous Shahsavarinia This is me
0000-0002-4049-8531
Iran

Babak Davami This is me
0000-0002-0645-7699
Iran

Hossein Nazemiyeh This is me
0000-0003-0165-3209
Iran

Aliasghar Kheiri This is me
0000-0002-5151-2423
Iran

Hadi Valizadeh This is me
0000-0003-4157-6279
Iran

Laleh Khodaie ^*
0000-0001-7416-0822
Iran

Afshin Gharekhani ^* This is me
0000-0003-1791-9120
Iran

Publication Date

June 28, 2025

Submission Date

June 21, 2023

Acceptance Date

July 6, 2023

Published in Issue

Year 2024 Volume: 28 Number: 3

IZ

https://izlik.org/JA42MN37DW

Cite

RIS / Bibtex

APA

Seyyedi, F., Shahsavarinia, K., Davami, B., Nazemiyeh, H., Kheiri, A., Valizadeh, H., Khodaie, L., & Gharekhani, A. (2025). Clinical assessment of an ointment obtained from Alkanna orientalis root extract in the management of burn wounds: a pilot cross-sectional clinical trial. Journal of Research in Pharmacy, 28(3), 621-629. https://izlik.org/JA42MN37DW

AMA

1.Seyyedi F, Shahsavarinia K, Davami B, et al. Clinical assessment of an ointment obtained from Alkanna orientalis root extract in the management of burn wounds: a pilot cross-sectional clinical trial. J. Res. Pharm. 2025;28(3):621-629. https://izlik.org/JA42MN37DW

Chicago

Seyyedi, Farnoush, Kavous Shahsavarinia, Babak Davami, et al. 2025. “Clinical Assessment of an Ointment Obtained from Alkanna Orientalis Root Extract in the Management of Burn Wounds: A Pilot Cross-Sectional Clinical Trial”. Journal of Research in Pharmacy 28 (3): 621-29. https://izlik.org/JA42MN37DW.

EndNote

Seyyedi F, Shahsavarinia K, Davami B, Nazemiyeh H, Kheiri A, Valizadeh H, Khodaie L, Gharekhani A (June 1, 2025) Clinical assessment of an ointment obtained from Alkanna orientalis root extract in the management of burn wounds: a pilot cross-sectional clinical trial. Journal of Research in Pharmacy 28 3 621–629.

IEEE

[1]F. Seyyedi et al., “Clinical assessment of an ointment obtained from Alkanna orientalis root extract in the management of burn wounds: a pilot cross-sectional clinical trial”, J. Res. Pharm., vol. 28, no. 3, pp. 621–629, June 2025, [Online]. Available: https://izlik.org/JA42MN37DW

ISNAD

Seyyedi, Farnoush - Shahsavarinia, Kavous - Davami, Babak - Nazemiyeh, Hossein - Kheiri, Aliasghar - Valizadeh, Hadi - Khodaie, Laleh - Gharekhani, Afshin. “Clinical Assessment of an Ointment Obtained from Alkanna Orientalis Root Extract in the Management of Burn Wounds: A Pilot Cross-Sectional Clinical Trial”. Journal of Research in Pharmacy 28/3 (June 1, 2025): 621-629. https://izlik.org/JA42MN37DW.

JAMA

1.Seyyedi F, Shahsavarinia K, Davami B, Nazemiyeh H, Kheiri A, Valizadeh H, Khodaie L, Gharekhani A. Clinical assessment of an ointment obtained from Alkanna orientalis root extract in the management of burn wounds: a pilot cross-sectional clinical trial. J. Res. Pharm. 2025;28:621–629.

MLA

Seyyedi, Farnoush, et al. “Clinical Assessment of an Ointment Obtained from Alkanna Orientalis Root Extract in the Management of Burn Wounds: A Pilot Cross-Sectional Clinical Trial”. Journal of Research in Pharmacy, vol. 28, no. 3, June 2025, pp. 621-9, https://izlik.org/JA42MN37DW.

Vancouver

1.Farnoush Seyyedi, Kavous Shahsavarinia, Babak Davami, Hossein Nazemiyeh, Aliasghar Kheiri, Hadi Valizadeh, Laleh Khodaie, Afshin Gharekhani. Clinical assessment of an ointment obtained from Alkanna orientalis root extract in the management of burn wounds: a pilot cross-sectional clinical trial. J. Res. Pharm. [Internet]. 2025 Jun. 1;28(3):621-9. Available from: https://izlik.org/JA42MN37DW