Assessing perfluorooctanoic acid toxicity in lung, heart, and testis tissues of mice: Evaluation of protective effects of taurine and coenzyme Q10

Burcu Ünlü Endirlik; Ayşe Eken; Figen Öztürk; Aylin Gürbay

Assessing perfluorooctanoic acid toxicity in lung, heart, and testis tissues of mice: Evaluation of protective effects of taurine and coenzyme Q10

Abstract

Perfluorooctanoic acid (PFOA) is a persistent compound which is associated with many negative effects on human health. In this study, possible oxidative stress inducing effects of PFOA and protective effects of taurine and coenzyme Q10 (CoQ10) in lung, heart and testes of mice were investigated. Animals were administered 15 and 30 mg/kg doses of PFOA orally for 10 days. All three organ weights were found to be affected in response to PFOA while taurine seemed to be effective against absolute heart weight reduction. PFOA was also found to induce histopathological changes in lung tissue. 15 mg/kg of PFOA reduced catalase (CAT) activity in lung; increased malondialdehyde (MDA) and total glutathione (GSH) levels, activities of superoxide dismutase (Cu-Zn SOD) and CAT in heart; and increased GSH levels and reduced Cu-Zn SOD and CAT activities in testes. On the other hand, 30 mg/kg PFOA treatment led to Cu-Zn SOD activity increase in lung; GSH level and Cu-Zn SOD activity increase in heart; and reduction of all three enzyme activities in testes. Taurine was found to be protective against Cu-Zn SOD activity increase in both lung and heart tissues, as well as against reduction of glutathione peroxidase (GPx) and CAT activities in the testes. CoQ10 seemed to protect against PFOA-induced increases in MDA levels in the heart tissue. These results suggest the oxidative stress involvement in the toxicity mechanism of an important environmental pollutant, PFOA, in lung, heart and testes of mice. Moreover, taurine and CoQ10 have protective role to some extent against PFOA-induced toxicity.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Toxicology

Journal Section

Research Article

Authors

Burcu Ünlü Endirlik
0000-0001-5960-1036
Türkiye

Ayşe Eken
0000-0003-4830-5770
Türkiye

Figen Öztürk
0000-0001-6180-5716
Türkiye

Aylin Gürbay
0000-0002-8571-1092
Türkiye

Publication Date

June 28, 2025

Submission Date

October 14, 2022

Acceptance Date

November 29, 2022

Published in Issue

Year 2023 Volume: 27 Number: 1

IZ

https://izlik.org/JA64TE57YE

Cite

RIS / Bibtex

APA

Ünlü Endirlik, B., Eken, A., Öztürk, F., & Gürbay, A. (2025). Assessing perfluorooctanoic acid toxicity in lung, heart, and testis tissues of mice: Evaluation of protective effects of taurine and coenzyme Q10. Journal of Research in Pharmacy, 27(1), 441-453. https://izlik.org/JA64TE57YE

AMA

1.Ünlü Endirlik B, Eken A, Öztürk F, Gürbay A. Assessing perfluorooctanoic acid toxicity in lung, heart, and testis tissues of mice: Evaluation of protective effects of taurine and coenzyme Q10. J. Res. Pharm. 2025;27(1):441-453. https://izlik.org/JA64TE57YE

Chicago

Ünlü Endirlik, Burcu, Ayşe Eken, Figen Öztürk, and Aylin Gürbay. 2025. “Assessing Perfluorooctanoic Acid Toxicity in Lung, Heart, and Testis Tissues of Mice: Evaluation of Protective Effects of Taurine and Coenzyme Q10”. Journal of Research in Pharmacy 27 (1): 441-53. https://izlik.org/JA64TE57YE.

EndNote

Ünlü Endirlik B, Eken A, Öztürk F, Gürbay A (June 1, 2025) Assessing perfluorooctanoic acid toxicity in lung, heart, and testis tissues of mice: Evaluation of protective effects of taurine and coenzyme Q10. Journal of Research in Pharmacy 27 1 441–453.

IEEE

[1]B. Ünlü Endirlik, A. Eken, F. Öztürk, and A. Gürbay, “Assessing perfluorooctanoic acid toxicity in lung, heart, and testis tissues of mice: Evaluation of protective effects of taurine and coenzyme Q10”, J. Res. Pharm., vol. 27, no. 1, pp. 441–453, June 2025, [Online]. Available: https://izlik.org/JA64TE57YE

ISNAD

Ünlü Endirlik, Burcu - Eken, Ayşe - Öztürk, Figen - Gürbay, Aylin. “Assessing Perfluorooctanoic Acid Toxicity in Lung, Heart, and Testis Tissues of Mice: Evaluation of Protective Effects of Taurine and Coenzyme Q10”. Journal of Research in Pharmacy 27/1 (June 1, 2025): 441-453. https://izlik.org/JA64TE57YE.

JAMA

1.Ünlü Endirlik B, Eken A, Öztürk F, Gürbay A. Assessing perfluorooctanoic acid toxicity in lung, heart, and testis tissues of mice: Evaluation of protective effects of taurine and coenzyme Q10. J. Res. Pharm. 2025;27:441–453.

MLA

Ünlü Endirlik, Burcu, et al. “Assessing Perfluorooctanoic Acid Toxicity in Lung, Heart, and Testis Tissues of Mice: Evaluation of Protective Effects of Taurine and Coenzyme Q10”. Journal of Research in Pharmacy, vol. 27, no. 1, June 2025, pp. 441-53, https://izlik.org/JA64TE57YE.

Vancouver

1.Burcu Ünlü Endirlik, Ayşe Eken, Figen Öztürk, Aylin Gürbay. Assessing perfluorooctanoic acid toxicity in lung, heart, and testis tissues of mice: Evaluation of protective effects of taurine and coenzyme Q10. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(1):441-53. Available from: https://izlik.org/JA64TE57YE