Dopamine detection by doped single-walled carbon nanotube biosensors: A theoretical study

N Maddady

Dopamine detection by doped single-walled carbon nanotube biosensors: A theoretical study

Abstract

In this paper, biosensors of the Fe-Nitrogen-doped zigzag (8, 0) carbon nanotube and Fe-doped zigzag (8, 0) carbon nanotube were offered for detection of dopamine molecule. The adsorption property and sensing mechanism of Fe-doped zigzag (8, 0) carbon nanotube and Fe-N-SWCNT (8, 0) with dopamine were investigated based on density functional theory. The obtained results demonstrated that both Fe-SWCNT and the Fe-N-SWCNT had good adsorption for dopamine, also conductivity also grew when they interacted with it. When dopamine is adsorbed on the surface of the single wall carbon nanotube, a large number of electrons transfer from the Fe-N-doped zigzag (8, 0) single carbon nanotube to dopamine, resulting in lessened frontier orbital energy gap and increased electrical conductivity. On the other hand, when dopamine is adsorbed on the surface of the SWCNT, the electrons transfer from dopamine to the FeN-SWCNT, the frontier orbital energy gap rises, while the electrical conductivity declines. Thus, Fe-nitrogen- SWCNT (8, 0) is more suitable and sufficient than Fe-SWCNT (8, 0) for dopamine detection.

Keywords

References

[1] Moradi R, Sebt SA, Karimi-Maleh H, Sadeghi R, Karimi F, Bahari A, Arabi H. Synthesis and application of FePt/CNTs nanocomposite as a sensor and novel amide ligand as a mediator for simultaneous determination of glutathione, nicotinamide adenine dinucleotide and tryptophan. Phys Chem Chem Phys. 2013; 15(16): 5888-5897. [CrossRef]
[2] Wang J, Musameh M, Lin Y. Solubilization of carbon nanotubes by nafion toward the preparation of amperometric biosensors. J Am Chem Soc. 2003; 125(9): 2408-2409. [CrossRef]
[3] Collins PG, Bradley K, Ishigami M, Zettl A. Extreme oxygen sensitivity of electronic properties of carbon nanotubes. Science. 2000; 287(5459): 1801-1804. [CrossRef]
[4] Zhang X, Cui H, Gui Y, Tang J. Mechanism and application of carbon nanotube sensors in SF6 decomposed production detection: A review. Nanoscale Res Lett. 2017; 12(1): 1945-1948. [CrossRef]
[5] Zhang X, Cui H, Gui Y, Tang J. Adsorption characteristic of Pd-4 cluster carbon nanotube towards transformer oil dissolved components: A simulation. Appl Surf Sci. 2017; 419: 802-810. [CrossRef]
[6] Asuri P, Bale SS, Pangule RC, Shah DA, Kane RS, Dordick JS. Structure, function, and stability of enzymes covalently attached to single-walled carbon nanotubes. Langmuir. 2007; 23(24): 12318-12321. [CrossRef]
[7] Bennet KE, Tomshine JR, Min HK, Manciu FS, Marsh MP, Paek SB, Settell ML, Nicolai EN, Blaha CD, Kouzani AZ, Chang SY, Lee KH. A Diamond-based electrode for detection of neurochemicals in the human brain. Front Hum Neurosci. 2016; 10: 102-112. [CrossRef]
[8] Zhang X, Dai Z, Chen Q, Tang J. A DFT study of SO2 and H2S gas adsorption on Au-doped single-walled carbon nanotubes. Phys Scr. 2014; 89(6): 065803. [CrossRef]

[9] Sharafeldin IM, Allam NK. DFT insights into the electronic properties and adsorption of NO2 on metal-doped carbon nanotubes for gas sensing applications. New J Chem. 2017; 41(24): 14936-14944. [CrossRef]
[10] Matyszewska D, Napora E, Zelechowska K, Biernat JF, Bilewicz R. Synthesis, characterization, and interactions of single-walled carbon nanotubes modified with doxorubicin with Langmuir-Blodgett biomimetic membranes. J Nanopart Res. 2018; 20(5): 143-159. [CrossRef]
[11] Li H, Wang X, Yu Z. Electrochemical biosensor for sensitively simultaneous determination of dopamine, uric acid, guanine, and adenine based on poly-melamine and nano Ag hybridized film-modified electrode. J Solid State Electrochem. 2014; 18(1): 105-113. [CrossRef]
[12] Ciano PD, Foll BL, Grandy D. Dopamine D4 receptors in psychostimulant addiction. Adv Pharmacol. 2014; 69: 301-321. [CrossRef]
[13] Stewart AJ, Hendry J, Dennany L. Whole blood electrochemiluminescent detection of dopamine. Anal Chem. 2015; 87(23): 11847-11853. [CrossRef]
[14] Heidbreder CA, Lacroix L, Atkins AR, Organ AJ, Murray S, West A, Shah AJ. Development and application of a sensitive high performance ion-exchange chromatography method for the simultaneous measurement of dopamine, 5-hydroxytryptamine and norepinephrine in microdialysates from the rat brain. J Neurosci Methods. 2001; 122: 135-144. [CrossRef]
[15] Maouche N, Ktari N, Bakas I, Fourati N, Zerrouki C, Seydou M, Maurel F, Chehimi MM. A surface acoustic wave sensor functionalized with a polypyrrole molecularly imprinted polymer for selective dopamine detection. J Mol Recognit. 2015; 28(11): 667-678. [CrossRef]
[16] Qiu C, Bennet KE, Tomshine JR, Hara S, Ciubuc JD, Schmidt U, Durrer W, Malcolm BM, Michael E, Felicia M. Ultrasensitive detection of neurotransmitters by surface enhanced raman spectroscopy for biosensing applications. Biointerface Res Appl Chem. 2017; 7: 1921-1926.
[17] Kim YR, Bong S, Kang Y-J, Yang Y, Mahajan RK, Kim JS, Kim H. Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes. Biosens Bioelectron. 2010; 25(10): 2366-2369. [CrossRef]
[18] Koyun O, Gursu H, Gordo S, Sahin Y. Highly Sensitive Electrochemical determination of dopamine with an overoxidized polypyrrole nanofiber pencil graphite electrode. Int J Electrochem Sci. 2017; 12: 6428-6444. [CrossRef]
[19] Mazouz Z, Rahali S, Fourati N, Zerrouki C, Aloui N, Seydou M, Yaakoubi N, Chehimi MM, Othmane A, Kalfat R. Highly selective polypyrrole MIP-based gravimetric and electrochemical sensors for picomolar detection of glyphosate. Sensors. 2017; 17(11): 2586-2597. [CrossRef]
[20] Ciubuc JD, Bennet KE, Qiu C, Alonzo M, Durrer WG, Manciu FS. Raman Computational and experimental studies of dopamine detection. Biosensors. 2017; 7(4): 43-51. [CrossRef]
[21] Jackowska K, Krysinski P. New trends in the electrochemical sensing of dopamine. Anal Bioanal Chem. 2013; 405: 3753-3771. [CrossRef]
[22] Lu JF, Yu ZY. Theoretical determinations of ionization potentials of dopamine. Russ J Phys Chem A. 2013; 87(4): 628-633. [CrossRef]
[23] Zestos AG, Yang C, Jacobs CB, Hensley D, Jill Venton B. Carbon nanospikes grown on metal wires as microelectrode sensors for dopamine. Analyst. 2015; 140: 7283–7292. [CrossRef]
[24] Sansuk S, Bitziou E, Joseph MB, Covington JA, Boutelle MG, Unwin PR, Macpherson JV. Ultrasensitive detection of dopamine using a carbon nanotube network microfluidic flow electrode. Anal Chem. 2013; 85(1): 163–169. [CrossRef]
[25] Tang L, Du D, Yang F, Liang Z, Ning Y, Wang H, Zhang GJ. Preparation of graphene-modified acupuncture needle and its application in detecting neurotransmitters. Sci Rep. 2015; 5: 11627-11636. [CrossRef]
[26] Kurniawan F, Kiswiyah NSA, Madurani KA, Tominaga M. Single-walled carbon nanotubes-modified gold electrode for dopamine detection. ECS J Solid State Sci Technol. 2017; 6: M3109–M3112.
[27] Sonawane MR, Nagare BJ, Habale D, Shivade RK. Comparative study of adsorption of O2, CO2, NO2 and SO2 on pristine and Si-doped carbon nanotubes. Adv Mat Res. 2013; 678: 179-184. [CrossRef]
[28] Wan Q, Xua Y, Chen X, Xiao H. Exhaled gas detection by a novel Rh-doped CNT biosensor for prediagnosis of lung cancer: A DFT study. Mol Phys. 2018; 116(17): 2205-2212. [CrossRef]
[29] Yeh CH, Hsiao YJ, Jiang JC. Dopamine sensing by boron and nitrogen Co-doped single-walled carbon nanotubes: A first-principles study. App Sur Sci. 2019; 473: 59-64. [CrossRef]
[30] Yoosefian M, Etminan N. Density functional theory (DFT) study of a new novel bionanosensor hybrid; tryptophan/Pd doped single walled carbon nanotube. Physica E. 2016; 81: 116-121.
[31] Delley B. From molecules to solids with the DMol3 approach. J Chem Phys. 2000; 113: 7756-7764. [CrossRef]
[32] Perdew JP, Wang Y. Accurate and simple analytic representation of the electron-gas correlation energy. Phys Rev B. 1992; 45: 13244-13249. [CrossRef]
[33] Delley B. An all-electron numerical method for solving the local density functional for polyatomic molecules. J Chem Phys. 1990; 92(1): 508–517. [CrossRef]

Details

Primary Language

English

Subjects

Pharmaceutical Biochemistry, Pharmaceutical Chemistry

Journal Section

Research Article

Authors

N Maddady ^*
Iran

Publication Date

June 27, 2025

Submission Date

December 25, 2018

Acceptance Date

April 14, 2019

Published in Issue

Year 2019 Volume: 23 Number: 5

IZ

https://izlik.org/JA65HS37DZ

Cite

RIS / Bibtex

APA

Maddady, N. (2025). Dopamine detection by doped single-walled carbon nanotube biosensors: A theoretical study. Journal of Research in Pharmacy, 23(5), 785-791. https://izlik.org/JA65HS37DZ

AMA

1.Maddady N. Dopamine detection by doped single-walled carbon nanotube biosensors: A theoretical study. J. Res. Pharm. 2025;23(5):785-791. https://izlik.org/JA65HS37DZ

Chicago

Maddady, N. 2025. “Dopamine Detection by Doped Single-Walled Carbon Nanotube Biosensors: A Theoretical Study”. Journal of Research in Pharmacy 23 (5): 785-91. https://izlik.org/JA65HS37DZ.

EndNote

Maddady N (July 1, 2025) Dopamine detection by doped single-walled carbon nanotube biosensors: A theoretical study. Journal of Research in Pharmacy 23 5 785–791.

IEEE

[1]N. Maddady, “Dopamine detection by doped single-walled carbon nanotube biosensors: A theoretical study”, J. Res. Pharm., vol. 23, no. 5, pp. 785–791, July 2025, [Online]. Available: https://izlik.org/JA65HS37DZ

ISNAD

Maddady, N. “Dopamine Detection by Doped Single-Walled Carbon Nanotube Biosensors: A Theoretical Study”. Journal of Research in Pharmacy 23/5 (July 1, 2025): 785-791. https://izlik.org/JA65HS37DZ.

JAMA

1.Maddady N. Dopamine detection by doped single-walled carbon nanotube biosensors: A theoretical study. J. Res. Pharm. 2025;23:785–791.

MLA

Maddady, N. “Dopamine Detection by Doped Single-Walled Carbon Nanotube Biosensors: A Theoretical Study”. Journal of Research in Pharmacy, vol. 23, no. 5, July 2025, pp. 785-91, https://izlik.org/JA65HS37DZ.

Vancouver

1.N Maddady. Dopamine detection by doped single-walled carbon nanotube biosensors: A theoretical study. J. Res. Pharm. [Internet]. 2025 Jul. 1;23(5):785-91. Available from: https://izlik.org/JA65HS37DZ