Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine

Nurgul Karadas Bakirhan; Bediha Akmeşe; Tuğçe Göver; Hamideh Imanzadeh; Sibel A. Özkan

Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine

Abstract

The degradation of daunorubicin (DNR), doxorubicin (DXR) and vincristine (VCR) as chemotherapeutic agents was investigated under stress conditions such as acidic and alkaline media, oxidation, photolytic and heating. The degradation pathway determined by high-performance liquid chromatography (HPLC). Daunorubicin, doxorubicin and vincristine completely disintegrated in the basic medium. It has been determined that these drugs are resistant to heat. Daunorubicin and doxorubicin are resistant to UV light. However, vincristine is not very stable such as the other two compounds against UV light. The kinetic and thermodynamic parameters of daunorubicin, doxorubicin and vincristine were investigated in neutral media with different temperatures by electrochemical technique. Enthalpy, entropy and Gibbs free energy parameters were investigated in pH 7.4 phosphate buffer (PB) solution due to stability of these drugs at this pH. The studied chemotherapeutic agents showed endothermic process on glassy carbon-based electrode surface. Daunorubicin, doxorubicin and vincristine showed strongly adsorption process in room temperature. However, it showed diffusion property from electrode to solution with increasing the temperature values.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry, Clinical Pharmacology and Therapeutics

Journal Section

Research Article

Authors

Nurgul Karadas Bakirhan ^*
Türkiye

Bediha Akmeşe This is me
Türkiye

Tuğçe Göver
Türkiye

Hamideh Imanzadeh This is me
Iran

Sibel A. Özkan ^*
Türkiye

Publication Date

June 27, 2025

Submission Date

July 27, 2019

Acceptance Date

September 2, 2019

Published in Issue

Year 2019 Volume: 23 Number: 5

IZ

https://izlik.org/JA65NT57UG

Cite

RIS / Bibtex

APA

Karadas Bakirhan, N., Akmeşe, B., Göver, T., Imanzadeh, H., & Özkan, S. A. (2025). Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine. Journal of Research in Pharmacy, 23(5), 822-831. https://izlik.org/JA65NT57UG

AMA

1.Karadas Bakirhan N, Akmeşe B, Göver T, Imanzadeh H, Özkan SA. Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine. J. Res. Pharm. 2025;23(5):822-831. https://izlik.org/JA65NT57UG

Chicago

Karadas Bakirhan, Nurgul, Bediha Akmeşe, Tuğçe Göver, Hamideh Imanzadeh, and Sibel A. Özkan. 2025. “Degradation Studies and Thermodynamic Parameters in Aqueous Solution of Chemotherapeutic Agents: Daunorubicin, Doxorubicin and Vincristine”. Journal of Research in Pharmacy 23 (5): 822-31. https://izlik.org/JA65NT57UG.

EndNote

Karadas Bakirhan N, Akmeşe B, Göver T, Imanzadeh H, Özkan SA (July 1, 2025) Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine. Journal of Research in Pharmacy 23 5 822–831.

IEEE

[1]N. Karadas Bakirhan, B. Akmeşe, T. Göver, H. Imanzadeh, and S. A. Özkan, “Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine”, J. Res. Pharm., vol. 23, no. 5, pp. 822–831, July 2025, [Online]. Available: https://izlik.org/JA65NT57UG

ISNAD

Karadas Bakirhan, Nurgul - Akmeşe, Bediha - Göver, Tuğçe - Imanzadeh, Hamideh - Özkan, Sibel A. “Degradation Studies and Thermodynamic Parameters in Aqueous Solution of Chemotherapeutic Agents: Daunorubicin, Doxorubicin and Vincristine”. Journal of Research in Pharmacy 23/5 (July 1, 2025): 822-831. https://izlik.org/JA65NT57UG.

JAMA

1.Karadas Bakirhan N, Akmeşe B, Göver T, Imanzadeh H, Özkan SA. Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine. J. Res. Pharm. 2025;23:822–831.

MLA

Karadas Bakirhan, Nurgul, et al. “Degradation Studies and Thermodynamic Parameters in Aqueous Solution of Chemotherapeutic Agents: Daunorubicin, Doxorubicin and Vincristine”. Journal of Research in Pharmacy, vol. 23, no. 5, July 2025, pp. 822-31, https://izlik.org/JA65NT57UG.

Vancouver

1.Nurgul Karadas Bakirhan, Bediha Akmeşe, Tuğçe Göver, Hamideh Imanzadeh, Sibel A. Özkan. Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine. J. Res. Pharm. [Internet]. 2025 Jul. 1;23(5):822-31. Available from: https://izlik.org/JA65NT57UG