Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation

Faika Başoğlu-ünal; Selin Cimok; Efe Doğukan Dincel; Lieve Naesens; Nuray Ulusoy Güzeldemirci

Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation

Abstract

This paper aimed to synthesize novel compounds carrying imidazo[2,1-b]thiazole nucleus, characterize them with various spectroscopic methods, moreover evaluate their antiviral activity. All novel derivatives were evaluated for their antiviral activity against Coxsackie B4 virus, Respiratory syncytial virus, Influenza A/H1N1 virus, Influenza A/H3N2, and Influenza B virus. Some of the compounds, particularly the derivatives carrying 4- methylphenyl and 4-bromophenyl moiety, exhibited higher and comparable activities against both Coxsackie B4 and Respiratory syncytial viruses, moreover the compounds with N-propyl and N-butyl at thiazolidinone ring showed high antiviral activities against Influenza Influenza A/H3N2 viruses. Consequently, the results obtained from in vitro assay data shed light on improving novel antiviral.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Faika Başoğlu-ünal ^* This is me
Türkiye

Selin Cimok This is me
0000-0002-6021-4065
Türkiye

Efe Doğukan Dincel
0000-0002-5445-0600
Türkiye

Lieve Naesens This is me
0000-0001-9742-9302
Belgium

Nuray Ulusoy Güzeldemirci
0000-0002-4495-4282
Türkiye

Publication Date

June 27, 2025

Submission Date

September 20, 2022

Acceptance Date

October 17, 2022

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA56GR47DD

Cite

RIS / Bibtex

APA

Başoğlu-ünal, F., Cimok, S., Dincel, E. D., Naesens, L., & Ulusoy Güzeldemirci, N. (2025). Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation. Journal of Research in Pharmacy, 27(2), 924-935. https://izlik.org/JA56GR47DD

AMA

1.Başoğlu-ünal F, Cimok S, Dincel ED, Naesens L, Ulusoy Güzeldemirci N. Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation. J. Res. Pharm. 2025;27(2):924-935. https://izlik.org/JA56GR47DD

Chicago

Başoğlu-ünal, Faika, Selin Cimok, Efe Doğukan Dincel, Lieve Naesens, and Nuray Ulusoy Güzeldemirci. 2025. “Novel 4-Thiazolidinone Derivatives Bearing Imidazo[2,1- B]thiazole Moiety: Design, Synthesis, and Antiviral Activity Evaluation”. Journal of Research in Pharmacy 27 (2): 924-35. https://izlik.org/JA56GR47DD.

EndNote

Başoğlu-ünal F, Cimok S, Dincel ED, Naesens L, Ulusoy Güzeldemirci N (June 1, 2025) Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation. Journal of Research in Pharmacy 27 2 924–935.

IEEE

[1]F. Başoğlu-ünal, S. Cimok, E. D. Dincel, L. Naesens, and N. Ulusoy Güzeldemirci, “Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation”, J. Res. Pharm., vol. 27, no. 2, pp. 924–935, June 2025, [Online]. Available: https://izlik.org/JA56GR47DD

ISNAD

Başoğlu-ünal, Faika - Cimok, Selin - Dincel, Efe Doğukan - Naesens, Lieve - Ulusoy Güzeldemirci, Nuray. “Novel 4-Thiazolidinone Derivatives Bearing Imidazo[2,1- B]thiazole Moiety: Design, Synthesis, and Antiviral Activity Evaluation”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 924-935. https://izlik.org/JA56GR47DD.

JAMA

1.Başoğlu-ünal F, Cimok S, Dincel ED, Naesens L, Ulusoy Güzeldemirci N. Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation. J. Res. Pharm. 2025;27:924–935.

MLA

Başoğlu-ünal, Faika, et al. “Novel 4-Thiazolidinone Derivatives Bearing Imidazo[2,1- B]thiazole Moiety: Design, Synthesis, and Antiviral Activity Evaluation”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 924-35, https://izlik.org/JA56GR47DD.

Vancouver

1.Faika Başoğlu-ünal, Selin Cimok, Efe Doğukan Dincel, Lieve Naesens, Nuray Ulusoy Güzeldemirci. Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):924-35. Available from: https://izlik.org/JA56GR47DD