Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation

Year 2023, Volume: 27 Issue: 2 , 924 - 935 , 27.06.2025

Faika Başoğlu-ünal Selin Cimok Efe Doğukan Dincel , Lieve Naesens Nuray Ulusoy Güzeldemirci

https://izlik.org/JA56GR47DD

Abstract

This paper aimed to synthesize novel compounds carrying imidazo[2,1-b]thiazole nucleus, characterize
them with various spectroscopic methods, moreover evaluate their antiviral activity. All novel derivatives were
evaluated for their antiviral activity against Coxsackie B4 virus, Respiratory syncytial virus, Influenza A/H1N1 virus,
Influenza A/H3N2, and Influenza B virus. Some of the compounds, particularly the derivatives carrying 4-
methylphenyl and 4-bromophenyl moiety, exhibited higher and comparable activities against both Coxsackie B4 and
Respiratory syncytial viruses, moreover the compounds with N-propyl and N-butyl at thiazolidinone ring showed high
antiviral activities against Influenza Influenza A/H3N2 viruses. Consequently, the results obtained from in vitro assay
data shed light on improving novel antiviral.

Keywords

Imidazo[2 , 1-b]thiazole , 4-thiazolidinone , antiviral activity , coxscakie b4 virus , influenza

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