Anti-Trichomonas vaginalis activities of some Lamiaceae plants

Abstract

Trichomoniasis is a sexually transmitted infection caused by the Trichomonas vaginalis, non-viral protozoan, affecting the world. Metronidazole is one of the effective treatments approved by the FDA. Natural alternative approaches are required due to developed of resistance and drug intolerance in long-term treatment. The Lamiaceae, with 250 genera and 3000 species, are one of the largest family based on the taxon numbers. Thymus, Salvia, and Phlomis are also the largest genus of the family. The most distinctive feature of the species is active compounds of antiprotozoal activities. In present study Phlomis armeniaca Willd., Phlomis pungens Willd. var. pungens, Phlomis sieheana Rech. Fil., Thymus haussknechtii Velen., Thymus kotschyanus Boiss. & Hohen. var. kotschyanus, Stachys lavandulifolia Vahl subsp. lavandulifolia and Salvia verticillata L. subsp. verticillata L. had investigated anti-Trichomonas vaginalis activity. Results indicated that Thymus haussknetchtii was found anti-trichomonal activity in 250 and 125 μg/ml concentrations at the end of 16 hours. The inhibition of Salvia verticillata subsp. verticillata and Phlomis sieheana. were started after 24 hours, and anti-trichomonal activity was detected 70% and 90% at the end of 48 hours, respectively.

Keywords

• Lamiaceae
• Phlomis
• Salvia
• Thymus
• Trichomonas vaginalis

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