Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles

Ahmet Doğan Ergin; Zerrin Sezgin Bayındır; Nilüfer Yüksel

Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles

Abstract

S-adenosyl-L-methionine (SAMe) is an endogenic methyl donor naturally present in all living cells; it has high water solubility, but its bioavailability is low in oral administration due to the first pass effect in the liver. The aim of this study is to prepare colon targeted chitosan nanoparticles containing SAMe by ionic gelation. In the preparation of the formulations, the effects of chitosan concentration, tripolyphosphate (TPP) concentration and the amount of SAMe on the specifications of the nanoparticles such as particle size, zeta potential, encapsulation efficiency, and process yield, were investigated. Drug-excipient interactions were evaluated by differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR) spectroscopy. The obtained nanoparticles showed bimodal particle size distribution ranging between 228.3-763.9 nm and their zeta potentials were within 14.10-23.30 mV. The drug encapsulation efficiencies and process yields of the nanoparticles were low. However, when the effects of the process parameters on the characteristics of nanoparticles were examined, the chitosan concentration and SAMe amount were significant parameters affecting particle size. The chitosan concentration was also found to have a significant effect on process yield (p <0.05). Drug release from nanoparticles was evaluated according to different kinetic models and it was found that the release mechanism was Fickian diffusion.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biotechnology, Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Ahmet Doğan Ergin ^* This is me
Türkiye

Zerrin Sezgin Bayındır
Türkiye

Nilüfer Yüksel This is me
Türkiye

Publication Date

June 27, 2025

Submission Date

August 1, 2019

Acceptance Date

August 29, 2019

Published in Issue

Year 2019 Volume: 23 Number: 5

IZ

https://izlik.org/JA63LE66HW

Cite

RIS / Bibtex

APA

Ergin, A. D., Sezgin Bayındır, Z., & Yüksel, N. (2025). Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. Journal of Research in Pharmacy, 23(5), 914-926. https://izlik.org/JA63LE66HW

AMA

1.Ergin AD, Sezgin Bayındır Z, Yüksel N. Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. J. Res. Pharm. 2025;23(5):914-926. https://izlik.org/JA63LE66HW

Chicago

Ergin, Ahmet Doğan, Zerrin Sezgin Bayındır, and Nilüfer Yüksel. 2025. “Characterization and Optimization of Colon Targeted S-Adenosyl-L-Methionine Loaded Chitosan Nanoparticles”. Journal of Research in Pharmacy 23 (5): 914-26. https://izlik.org/JA63LE66HW.

EndNote

Ergin AD, Sezgin Bayındır Z, Yüksel N (July 1, 2025) Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. Journal of Research in Pharmacy 23 5 914–926.

IEEE

[1]A. D. Ergin, Z. Sezgin Bayındır, and N. Yüksel, “Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles”, J. Res. Pharm., vol. 23, no. 5, pp. 914–926, July 2025, [Online]. Available: https://izlik.org/JA63LE66HW

ISNAD

Ergin, Ahmet Doğan - Sezgin Bayındır, Zerrin - Yüksel, Nilüfer. “Characterization and Optimization of Colon Targeted S-Adenosyl-L-Methionine Loaded Chitosan Nanoparticles”. Journal of Research in Pharmacy 23/5 (July 1, 2025): 914-926. https://izlik.org/JA63LE66HW.

JAMA

1.Ergin AD, Sezgin Bayındır Z, Yüksel N. Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. J. Res. Pharm. 2025;23:914–926.

MLA

Ergin, Ahmet Doğan, et al. “Characterization and Optimization of Colon Targeted S-Adenosyl-L-Methionine Loaded Chitosan Nanoparticles”. Journal of Research in Pharmacy, vol. 23, no. 5, July 2025, pp. 914-26, https://izlik.org/JA63LE66HW.

Vancouver

1.Ahmet Doğan Ergin, Zerrin Sezgin Bayındır, Nilüfer Yüksel. Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. J. Res. Pharm. [Internet]. 2025 Jul. 1;23(5):914-26. Available from: https://izlik.org/JA63LE66HW