Immunomodulatory and immunostimulatory effects of some bisbenzoxazole derivatives on lipopolysaccharide stimulated mammalian macrophages

Furkan Ayaz; Qadar Ahmed Isse; Rusmeenee Kheeree; Ronak Haj Ersan; Öztekin Algül

Immunomodulatory and immunostimulatory effects of some bisbenzoxazole derivatives on lipopolysaccharide stimulated mammalian macrophages

Abstract

Benzoxazoles and their derivatives have exerted anti-cancer and anti-inflammatory (immunomodulatory) potential due to their anti-proliferative effect on the cells. These molecules are DNA basebioisosteres, therefore, their mechanism of action could be by mimicking the structures of the DNA bases and halting the DNA polymerization processes. Based on their anti-proliferative effect, in our study we aimed to decipher the potential anti-inflammatory activities of unique bisbenzoxazole derivatives in vitro on mammalian macrophages. Being able to manipulate the inflammatory function of macrophages would enable the regulation of the immune response against danger stimuli. This would enable us better prognosis against different types of the diseases ranging from autoimmune disorders to cancer. Our results support the stark anti-inflammatory potential of bisbenzoxazole derivatives RHE 241 and RHE 248 in vitro on the LPS activated mammalian macrophages. After further delineation of their mechanism of action in vitro and their in vivo potency, these molecules could be utilized as potent anti-inflammatory medicines.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biotechnology, Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Furkan Ayaz ^*
Türkiye

Qadar Ahmed Isse This is me
Türkiye

Rusmeenee Kheeree This is me
Türkiye

Ronak Haj Ersan This is me
Türkiye

Öztekin Algül ^*
Türkiye

Publication Date

June 27, 2025

Submission Date

January 22, 2019

Acceptance Date

June 2, 2019

Published in Issue

Year 2019 Volume: 23 Number: 5

IZ

https://izlik.org/JA26GZ69KY

Cite

RIS / Bibtex

APA

Ayaz, F., Isse, Q. A., Kheeree, R., Ersan, R. H., & Algül, Ö. (2025). Immunomodulatory and immunostimulatory effects of some bisbenzoxazole derivatives on lipopolysaccharide stimulated mammalian macrophages. Journal of Research in Pharmacy, 23(5), 944-951. https://izlik.org/JA26GZ69KY

AMA

1.Ayaz F, Isse QA, Kheeree R, Ersan RH, Algül Ö. Immunomodulatory and immunostimulatory effects of some bisbenzoxazole derivatives on lipopolysaccharide stimulated mammalian macrophages. J. Res. Pharm. 2025;23(5):944-951. https://izlik.org/JA26GZ69KY

Chicago

Ayaz, Furkan, Qadar Ahmed Isse, Rusmeenee Kheeree, Ronak Haj Ersan, and Öztekin Algül. 2025. “Immunomodulatory and Immunostimulatory Effects of Some Bisbenzoxazole Derivatives on Lipopolysaccharide Stimulated Mammalian Macrophages”. Journal of Research in Pharmacy 23 (5): 944-51. https://izlik.org/JA26GZ69KY.

EndNote

Ayaz F, Isse QA, Kheeree R, Ersan RH, Algül Ö (July 1, 2025) Immunomodulatory and immunostimulatory effects of some bisbenzoxazole derivatives on lipopolysaccharide stimulated mammalian macrophages. Journal of Research in Pharmacy 23 5 944–951.

IEEE

[1]F. Ayaz, Q. A. Isse, R. Kheeree, R. H. Ersan, and Ö. Algül, “Immunomodulatory and immunostimulatory effects of some bisbenzoxazole derivatives on lipopolysaccharide stimulated mammalian macrophages”, J. Res. Pharm., vol. 23, no. 5, pp. 944–951, July 2025, [Online]. Available: https://izlik.org/JA26GZ69KY

ISNAD

Ayaz, Furkan - Isse, Qadar Ahmed - Kheeree, Rusmeenee - Ersan, Ronak Haj - Algül, Öztekin. “Immunomodulatory and Immunostimulatory Effects of Some Bisbenzoxazole Derivatives on Lipopolysaccharide Stimulated Mammalian Macrophages”. Journal of Research in Pharmacy 23/5 (July 1, 2025): 944-951. https://izlik.org/JA26GZ69KY.

JAMA

1.Ayaz F, Isse QA, Kheeree R, Ersan RH, Algül Ö. Immunomodulatory and immunostimulatory effects of some bisbenzoxazole derivatives on lipopolysaccharide stimulated mammalian macrophages. J. Res. Pharm. 2025;23:944–951.

MLA

Ayaz, Furkan, et al. “Immunomodulatory and Immunostimulatory Effects of Some Bisbenzoxazole Derivatives on Lipopolysaccharide Stimulated Mammalian Macrophages”. Journal of Research in Pharmacy, vol. 23, no. 5, July 2025, pp. 944-51, https://izlik.org/JA26GZ69KY.

Vancouver

1.Furkan Ayaz, Qadar Ahmed Isse, Rusmeenee Kheeree, Ronak Haj Ersan, Öztekin Algül. Immunomodulatory and immunostimulatory effects of some bisbenzoxazole derivatives on lipopolysaccharide stimulated mammalian macrophages. J. Res. Pharm. [Internet]. 2025 Jul. 1;23(5):944-51. Available from: https://izlik.org/JA26GZ69KY