Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles

Erkan Özbay; Ülkü Çömelekoglu; Yusuf Vayısoğlu; Önder Albayrak; Rabia Bozdoğan Arpaci; Burcu Demirbağ; Döndü Anış Deniz; Derya Ümit Talaş

Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles

Abstract

Toxic effects of silica nanoparticle of rats exposed intratympanically for 7 days were investigated using brainstem auditory evoked potential and distortion product otoacoustic emission techniques. The histopathological changes were evaluated with light microscopy and field emission-scanning electron microscopy were demonstrated in cochleas using based energy-dispersive X-ray spectroscopy. The reduction in the amplitude and prolongation at the peak latency and interpeak latencies of brainstem auditory evoked potential were observed. Silica nanoparticles significantly reduced distortion product otoacoustic emission amplitude in the 2, 3 and 4 kHz frequencies. In the light microscopic evaluation, the samples obtained from the experimental group showed a significant loss of hair cells. Field emission scanning electron microscope analysis of experimental group showed considerable hair cell damage compared to control group. The findings of this study show that intratympanic administration of silica nanoparticles may lead to hearing impairment by causing structural changes in cochlear hair cells.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biochemistry

Journal Section

Research Article

Authors

Erkan Özbay
Türkiye

Ülkü Çömelekoglu ^*
Türkiye

Yusuf Vayısoğlu
Türkiye

Önder Albayrak This is me
Türkiye

Rabia Bozdoğan Arpaci This is me
Türkiye

Burcu Demirbağ This is me
Türkiye

Döndü Anış Deniz This is me
Türkiye

Derya Ümit Talaş This is me
Türkiye

Publication Date

June 27, 2025

Submission Date

July 1, 2019

Acceptance Date

September 13, 2019

Published in Issue

Year 2019 Volume: 23 Number: 6

IZ

https://izlik.org/JA74ER24KP

Cite

RIS / Bibtex

APA

Özbay, E., Çömelekoglu, Ü., Vayısoğlu, Y., Albayrak, Ö., Bozdoğan Arpaci, R., Demirbağ, B., Deniz, D. A., & Talaş, D. Ü. (2025). Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. Journal of Research in Pharmacy, 23(6), 1115-1122. https://izlik.org/JA74ER24KP

AMA

1.Özbay E, Çömelekoglu Ü, Vayısoğlu Y, et al. Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. J. Res. Pharm. 2025;23(6):1115-1122. https://izlik.org/JA74ER24KP

Chicago

Özbay, Erkan, Ülkü Çömelekoglu, Yusuf Vayısoğlu, et al. 2025. “Cochlear Electrophysiology and Histopathology of Rats Exposed to Intratympanic Silica Nanoparticles”. Journal of Research in Pharmacy 23 (6): 1115-22. https://izlik.org/JA74ER24KP.

EndNote

Özbay E, Çömelekoglu Ü, Vayısoğlu Y, Albayrak Ö, Bozdoğan Arpaci R, Demirbağ B, Deniz DA, Talaş DÜ (July 1, 2025) Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. Journal of Research in Pharmacy 23 6 1115–1122.

IEEE

[1]E. Özbay et al., “Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles”, J. Res. Pharm., vol. 23, no. 6, pp. 1115–1122, July 2025, [Online]. Available: https://izlik.org/JA74ER24KP

ISNAD

Özbay, Erkan - Çömelekoglu, Ülkü - Vayısoğlu, Yusuf - Albayrak, Önder - Bozdoğan Arpaci, Rabia - Demirbağ, Burcu - Deniz, Döndü Anış - Talaş, Derya Ümit. “Cochlear Electrophysiology and Histopathology of Rats Exposed to Intratympanic Silica Nanoparticles”. Journal of Research in Pharmacy 23/6 (July 1, 2025): 1115-1122. https://izlik.org/JA74ER24KP.

JAMA

1.Özbay E, Çömelekoglu Ü, Vayısoğlu Y, Albayrak Ö, Bozdoğan Arpaci R, Demirbağ B, Deniz DA, Talaş DÜ. Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. J. Res. Pharm. 2025;23:1115–1122.

MLA

Özbay, Erkan, et al. “Cochlear Electrophysiology and Histopathology of Rats Exposed to Intratympanic Silica Nanoparticles”. Journal of Research in Pharmacy, vol. 23, no. 6, July 2025, pp. 1115-22, https://izlik.org/JA74ER24KP.

Vancouver

1.Erkan Özbay, Ülkü Çömelekoglu, Yusuf Vayısoğlu, Önder Albayrak, Rabia Bozdoğan Arpaci, Burcu Demirbağ, Döndü Anış Deniz, Derya Ümit Talaş. Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. J. Res. Pharm. [Internet]. 2025 Jul. 1;23(6):1115-22. Available from: https://izlik.org/JA74ER24KP